Browsing by Author "Thomas M"

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    Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
    (Springer Nature, 2023-10-02) Thomas M; Su Y-R; Rosenthal EA; Sakoda LC; Schmit SL; Timofeeva MN; Chen Z; Fernandez-Rozadilla C; Law PJ; Murphy N; Carreras-Torres R; Diez-Obrero V; van Duijnhoven FJB; Jiang S; Shin A; Wolk A; Phipps AI; Burnett-Hartman A; Gsur A; Chan AT; Zauber AG; Wu AH; Lindblom A; Um CY; Tangen CM; Gignoux C; Newton C; Haiman CA; Qu C; Bishop DT; Buchanan DD; Crosslin DR; Conti DV; Kim D-H; Hauser E; White E; Siegel E; Schumacher FR; Rennert G; Giles GG; Hampel H; Brenner H; Oze I; Oh JH; Lee JK; Schneider JL; Chang-Claude J; Kim J; Huyghe JR; Zheng J; Hampe J; Greenson J; Hopper JL; Palmer JR; Visvanathan K; Matsuo K; Matsuda K; Jung KJ; Li L; Le Marchand L; Vodickova L; Bujanda L; Gunter MJ; Matejcic M; Jenkins MA; Slattery ML; D'Amato M; Wang M; Hoffmeister M; Woods MO; Kim M; Song M; Iwasaki M; Du M; Udaltsova N; Sawada N; Vodicka P; Campbell PT; Newcomb PA; Cai Q; Pearlman R; Pai RK; Schoen RE; Steinfelder RS; Haile RW; Vandenputtelaar R; Prentice RL; Küry S; Castellví-Bel S; Tsugane S; Berndt SI; Lee SC; Brezina S; Weinstein SJ; Chanock SJ; Jee SH; Kweon S-S; Vadaparampil S; Harrison TA; Yamaji T; Keku TO; Vymetalkova V; Arndt V; Jia W-H; Shu X-O; Lin Y; Ahn Y-O; Stadler ZK; Van Guelpen B; Ulrich CM; Platz EA; Potter JD; Li CI; Meester R; Moreno V; Figueiredo JC; Casey G; Lansdorp Vogelaar I; Dunlop MG; Gruber SB; Hayes RB; Pharoah PDP; Houlston RS; Jarvik GP; Tomlinson IP; Zheng W; Corley DA; Peters U; Hsu L
    Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
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    Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
    (Springer Nature, 2024-04-26) Chen Z; Guo X; Tao R; Huyghe JR; Law PJ; Fernandez-Rozadilla C; Ping J; Jia G; Long J; Li C; Shen Q; Xie Y; Timofeeva MN; Thomas M; Schmit SL; Díez-Obrero V; Devall M; Moratalla-Navarro F; Fernandez-Tajes J; Palles C; Sherwood K; Briggs SEW; Svinti V; Donnelly K; Farrington SM; Blackmur J; Vaughan-Shaw PG; Shu X-O; Lu Y; Broderick P; Studd J; Harrison TA; Conti DV; Schumacher FR; Melas M; Rennert G; Obón-Santacana M; Martín-Sánchez V; Oh JH; Kim J; Jee SH; Jung KJ; Kweon S-S; Shin M-H; Shin A; Ahn Y-O; Kim D-H; Oze I; Wen W; Matsuo K; Matsuda K; Tanikawa C; Ren Z; Gao Y-T; Jia W-H; Hopper JL; Jenkins MA; Win AK; Pai RK; Figueiredo JC; Haile RW; Gallinger S; Woods MO; Newcomb PA; Duggan D; Cheadle JP; Kaplan R; Kerr R; Kerr D; Kirac I; Böhm J; Mecklin J-P; Jousilahti P; Knekt P; Aaltonen LA; Rissanen H; Pukkala E; Eriksson JG; Cajuso T; Hänninen U; Kondelin J; Palin K; Tanskanen T; Renkonen-Sinisalo L; Männistö S; Albanes D; Weinstein SJ; Ruiz-Narvaez E; Palmer JR; Buchanan DD; Platz EA; Visvanathan K; Ulrich CM; Siegel E; Brezina S; Gsur A; Campbell PT; Chang-Claude J; Hoffmeister M; Brenner H; Slattery ML; Potter JD; Tsilidis KK; Schulze MB; Gunter MJ; Murphy N; Castells A; Castellví-Bel S; Moreira L; Arndt V; Shcherbina A; Bishop DT; Giles GG; Southey MC; Idos GE; McDonnell KJ; Abu-Ful Z; Greenson JK; Shulman K; Lejbkowicz F; Offit K; Su Y-R; Steinfelder R; Keku TO; van Guelpen B; Hudson TJ; Hampel H; Pearlman R; Berndt SI; Hayes RB; Martinez ME; Thomas SS; Pharoah PDP; Larsson SC; Yen Y; Lenz H-J; White E; Li L; Doheny KF; Pugh E; Shelford T; Chan AT; Cruz-Correa M; Lindblom A; Hunter DJ; Joshi AD; Schafmayer C; Scacheri PC; Kundaje A; Schoen RE; Hampe J; Stadler ZK; Vodicka P; Vodickova L; Vymetalkova V; Edlund CK; Gauderman WJ; Shibata D; Toland A; Markowitz S; Kim A; Chanock SJ; van Duijnhoven F; Feskens EJM; Sakoda LC; Gago-Dominguez M; Wolk A; Pardini B; FitzGerald LM; Lee SC; Ogino S; Bien SA; Kooperberg C; Li CI; Lin Y; Prentice R; Qu C; Bézieau S; Yamaji T; Sawada N; Iwasaki M; Le Marchand L; Wu AH; Qu C; McNeil CE; Coetzee G; Hayward C; Deary IJ; Harris SE; Theodoratou E; Reid S; Walker M; Ooi LY; Lau KS; Zhao H; Hsu L; Cai Q; Dunlop MG; Gruber SB; Houlston RS; Moreno V; Casey G; Peters U; Tomlinson I; Zheng W
    Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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    Managing at source and at scale: The use of geomorphic river stories to support rehabilitation of Anthropocene riverscapes in the East Coast Region of Aotearoa New Zealand
    (Frontiers Media S A for American Physical Society, 2023-04-13) Fuller IC; Brierley GJ; Tunnicliffe J; Marden M; McCord J; Rosser B; Hikuroa D; Harvey K; Stevens E; Thomas M; Thoms M
    Recently uplifted, highly erodible rocks, and recurrent high intensity storms, generate exceedingly high erosion and sedimentation rates in the East Coast Region (Tairāwhiti) of Aotearoa New Zealand. Despite the recent nature of the Anthropocene record in global terms (∼650 years since Māori arrival, 250 years of colonial impacts), human disturbance has profoundly altered evolutionary trajectories of river systems across the region. Here we document catchment-by-catchment variability in anthropogenic signature as geomorphic river stories for five catchments (Waiapu, Hikuwai, Waimatā, Waipaoa, Mōtū). We show how targeted, fit-for-purpose process-based rehabilitation programmes that manage at source and at scale are required to facilitate river recovery in each of these catchments. The largest rivers in the region, Waiapu and Waipaoa, comprise steep, highly dissected terrains that are subject to recurrent hillslope failures, including systemic shallow landslides, occasional deep-seated rotational slumps and earthflows. Localised sediment input from large (>10 ha) gully mass movement complexes overwhelms valley floors. Targeted revegetation programmes are required to reduce extreme sediment inputs from these sources. Although there are fewer gully complexes in the Hikuwai, multiple landslips supply vast volumes of fine-grained sediment that aggrade and are recurrently reworked along channel margins in lowland reaches. Waimatā has no gully complexes and a smaller number of landslips, but large areas are subject to sediment input from earthflows. The terrace-constrained flume-like nature of this system efficiently flushes materials ‘from the mountains to the sea’, recurrently reworking materials along channel banks in a similar manner to the lower Hikuwai. Systematic reforestation in the middle-upper catchment and revegetation of riparian corridors is required to reduce sedimentation rates in these catchments. In contrast, terraces buffer sediment delivery from hillslopes in the upper Mōtū catchment, where a bedrock gorge separates large sediment stores along upper reaches from the lower catchment. As reworking of valley floor sediments in response to bed incision and reworking (expansion) of channel margins is the primary contemporary sediment source in this system, bed control structures and revegetation of riparian corridors are required as part of targeted sediment management plans. We contend that geomorphic river stories provide a coherent platform for Anthropocene rehabilitation strategies that work with the character, behaviour and evolutionary trajectories of river systems. Although this generic lens can be applied anywhere in the world, we highlight particular meanings and implications in Aotearoa New Zealand where such thinking aligns directly with Māori values that respect the mana (authority), mauri (lifeforce) and ora (wellbeing) of each and every river
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    Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV.
    (AMER PHYSICAL SOC, 9/07/2010) Khachatryan V; Sirunyan AM; Tumasyan A; Adam W; Bergauer T; Dragicevic M; Erö J; Fabjan C; Friedl M; Frühwirth R; Ghete VM; Hammer J; Hänsel S; Hoch M; Hörmann N; Hrubec J; Jeitler M; Kasieczka G; Kiesenhofer W; Krammer M; Liko D; Mikulec I; Pernicka M; Rohringer H; Schöfbeck R; Strauss J; Taurok A; Teischinger F; Waltenberger W; Walzel G; Widl E; Wulz C-E; Mossolov V; Shumeiko N; Suarez Gonzalez J; Benucci L; Ceard L; De Wolf EA; Hashemi M; Janssen X; Maes T; Mucibello L; Ochesanu S; Roland B; Rougny R; Selvaggi M; Van Haevermaet H; Van Mechelen P; Van Remortel N; Adler V; Beauceron S; Blyweert S; D'Hondt J; Devroede O; Kalogeropoulos A; Maes J; Maes M; Tavernier S; Van Doninck W; Van Mulders P; Villella I; Chabert EC; Charaf O; Clerbaux B; De Lentdecker G; Dero V; Gay APR; Hammad GH; Marage PE; Vander Velde C; Vanlaer P; Wickens J; Costantini S; Grunewald M; Klein B; Marinov A; Ryckbosch D; Thyssen F; Tytgat M; Vanelderen L; Verwilligen P; Walsh S; Zaganidis N; Basegmez S; Bruno G; Caudron J; De Favereau De Jeneret J; Delaere C; Demin P; Favart D; Giammanco A; Grégoire G; Hollar J; Lemaitre V; Militaru O; Ovyn S; Pagano D; Pin A; Piotrzkowski K; Quertenmont L; Schul N; Beliy N; Caebergs T; Daubie E; Alves GA; Pol ME; Souza MHG; Carvalho W; Da Costa EM; De Jesus Damiao D; De Oliveira Martins C; Fonseca De Souza S; Mundim L; Oguri V; Santoro A; Silva Do Amaral SM; Sznajder A; Torres Da Silva De Araujo F; Dias FA; Dias MAF; Fernandez Perez Tomei TR; Gregores EM; Marinho F; Novaes SF; Padula SS; Darmenov N; Dimitrov L; Genchev V; Iaydjiev P; Piperov S; Stoykova S; Sultanov G; Trayanov R; Vankov I; Dyulendarova M; Hadjiiska R; Kozhuharov V; Litov L; Marinova E; Mateev M; Pavlov B; Petkov P; Bian JG; Chen GM; Chen HS; Jiang CH; Liang D; Liang S; Wang J; Wang J; Wang X; Wang Z; Yang M; Zang J; Zhang Z; Ban Y; Guo S; Hu Z; Mao Y; Qian SJ; Teng H; Zhu B; Cabrera A; Carrillo Montoya CA; Gomez Moreno B; Ocampo Rios AA; Osorio Oliveros AF; Sanabria JC; Godinovic N; Lelas D; Lelas K; Plestina R; Polic D; Puljak I; Antunovic Z; Dzelalija M; Brigljevic V; Duric S; Kadija K; Morovic S; Attikis A; Fereos R; Galanti M; Mousa J; Nicolaou C; Papadakis A; Ptochos F; Razis PA; Rykaczewski H; Tsiakkouri D; Zinonos Z; Mahmoud M; Hektor A; Kadastik M; Kannike K; Müntel M; Raidal M; Rebane L; Azzolini V; Eerola P; Czellar S; Härkönen J; Heikkinen A; Karimäki V; Kinnunen R; Klem J; Kortelainen MJ; Lampén T; Lassila-Perini K; Lehti S; Lindén T; Luukka P; Mäenpää T; Tuominen E; Tuominiemi J; Tuovinen E; Ungaro D; Wendland L; Banzuzi K; Korpela A; Tuuva T; Sillou D; Besancon M; Dejardin M; Denegri D; Descamps J; Fabbro B; Faure JL; Ferri F; Ganjour S; Gentit FX; Givernaud A; Gras P; Hamel de Monchenault G; Jarry P; Locci E; Malcles J; Marionneau M; Millischer L; Rander J; Rosowsky A; Rousseau D; Titov M; Verrecchia P; Baffioni S; Bianchini L; Bluj M; Broutin C; Busson P; Charlot C; Dobrzynski L; Elgammal S; Granier de Cassagnac R; Haguenauer M; Kalinowski A; Miné P; Paganini P; Sabes D; Sirois Y; Thiebaux C; Zabi A; Agram J-L; Besson A; Bloch D; Bodin D; Brom J-M; Cardaci M; Conte E; Drouhin F; Ferro C; Fontaine J-C; Gelé D; Goerlach U; Greder S; Juillot P; Karim M; Le Bihan A-C; Mikami Y; Speck J; Van Hove P; Fassi F; Mercier D; Baty C; Beaupere N; Bedjidian M; Bondu O; Boudoul G; Boumediene D; Brun H; Chanon N; Chierici R; Contardo D; Depasse P; El Mamouni H; Fay J; Gascon S; Ille B; Kurca T; Le Grand T; Lethuillier M; Mirabito L; Perries S; Tosi S; Tschudi Y; Verdier P; Xiao H; Roinishvili V; Anagnostou G; Edelhoff M; Feld L; Heracleous N; Hindrichs O; Jussen R; Klein K; Merz J; Mohr N; Ostapchuk A; Perieanu A; Raupach F; Sammet J; Schael S; Sprenger D; Weber H; Weber M; Wittmer B; Actis O; Ata M; Bender W; Biallass P; Erdmann M; Frangenheim J; Hebbeker T; Hinzmann A; Hoepfner K; Hof C; Kirsch M; Klimkovich T; Kreuzer P; Lanske D; Magass C; Merschmeyer M; Meyer A; Papacz P; Pieta H; Reithler H; Schmitz SA; Sonnenschein L; Sowa M; Steggemann J; Teyssier D; Zeidler C; Bontenackels M; Davids M; Duda M; Flügge G; Geenen H; Giffels M; Haj Ahmad W; Heydhausen D; Kress T; Kuessel Y; Linn A; Nowack A; Perchalla L; Pooth O; Sauerland P; Stahl A; Thomas M; Tornier D; Zoeller MH; Aldaya Martin M; Behrenhoff W; Behrens U; Bergholz M; Borras K; Campbell A; Castro E; Dammann D; Eckerlin G; Flossdorf A; Flucke G; Geiser A; Hauk J; Jung H; Kasemann M; Katkov I; Kleinwort C; Kluge H; Knutsson A; Kuznetsova E; Lange W; Lohmann W; Mankel R; Marienfeld M; Melzer-Pellmann I-A; Meyer AB; Mnich J; Mussgiller A; Olzem J; Parenti A; Raspereza A; Schmidt R; Schoerner-Sadenius T; Sen N; Stein M; Tomaszewska J; Volyanskyy D; Wissing C; Autermann C; Draeger J; Eckstein D; Enderle H; Gebbert U; Kaschube K; Kaussen G; Klanner R; Mura B; Naumann-Emme S; Nowak F; Sander C; Schettler H; Schleper P; Schröder M; Schum T; Schwandt J; Stadie H; Steinbrück G; Thomsen J; Wolf R; Bauer J; Buege V; Cakir A; Chwalek T; Daeuwel D; De Boer W; Dierlamm A; Dirkes G; Feindt M; Gruschke J; Hackstein C; Hartmann F; Heinrich M; Held H; Hoffmann KH; Honc S; Kuhr T; Martschei D; Mueller S; Müller T; Niegel M; Oberst O; Oehler A; Ott J; Peiffer T; Piparo D; Quast G; Rabbertz K; Ratnikov F; Renz M; Sabellek A; Saout C; Scheurer A; Schieferdecker P; Schilling F-P; Schott G; Simonis HJ; Stober FM; Troendle D; Wagner-Kuhr J; Zeise M; Zhukov V; Ziebarth EB; Daskalakis G; Geralis T; Kyriakis A; Loukas D; Manolakos I; Markou A; Markou C; Mavrommatis C; Petrakou E; Gouskos L; Katsas P; Panagiotou A; Evangelou I; Kokkas P; Manthos N; Papadopoulos I; Patras V; Triantis FA; Aranyi A; Bencze G; Boldizsar L; Debreczeni G; Hajdu C; Horvath D; Kapusi A; Krajczar K; Laszlo A; Sikler F; Vesztergombi G; Beni N; Molnar J; Palinkas J; Szillasi Z; Veszpremi V; Raics P; Trocsanyi ZL; Ujvari B; Bansal S; Beri SB; Bhatnagar V; Jindal M; Kaur M; Kohli JM; Mehta MZ; Nishu N; Saini LK; Sharma A; Sharma R; Singh AP; Singh JB; Singh SP; Ahuja S; Bhattacharya S; Chauhan S; Choudhary BC; Gupta P; Jain S; Jain S; Kumar A; Ranjan K; Shivpuri RK; Choudhury RK; Dutta D; Kailas S; Kataria SK; Mohanty AK; Pant LM; Shukla P; Suggisetti P; Aziz T; Guchait M; Gurtu A; Maity M; Majumder D; Majumder G; Mazumdar K; Mohanty GB; Saha A; Sudhakar K; Wickramage N; Banerjee S; Dugad S; Mondal NK; Arfaei H; Bakhshiansohi H; Fahim A; Jafari A; Mohammadi Najafabadi M; Paktinat Mehdiabadi S; Safarzadeh B; Zeinali M; Abbrescia M; Barbone L; Colaleo A; Creanza D; De Filippis N; De Palma M; Dimitrov A; Fedele F; Fiore L; Iaselli G; Lusito L; Maggi G; Maggi M; Manna N; Marangelli B; My S; Nuzzo S; Pierro GA; Pompili A; Pugliese G; Romano F; Roselli G; Selvaggi G; Silvestris L; Trentadue R; Tupputi S; Zito G; Abbiendi G; Benvenuti AC; Bonacorsi D; Braibant-Giacomelli S; Castro A; Cavallo FR; Codispoti G; Dallavalle GM; Fabbri F; Fanfani A; Fasanella D; Giacomelli P; Giunta M; Grandi C; Marcellini S; Masetti G; Montanari A; Navarria FL; Odorici F; Perrotta A; Rossi AM; Rovelli T; Siroli G; Travaglini R; Albergo S; Cappello G; Chiorboli M; Costa S; Tricomi A; Tuve C; Barbagli G; Broccolo G; Ciulli V; Civinini C; D'Alessandro R; Focardi E; Frosali S; Gallo E; Genta C; Lenzi P; Meschini M; Paoletti S; Sguazzoni G; Tropiano A; Benussi L; Bianco S; Colafranceschi S; Fabbri F; Piccolo D; Fabbricatore P; Musenich R; Benaglia A; Cerati GB; De Guio F; Di Matteo L; Ghezzi A; Govoni P; Malberti M; Malvezzi S; Martelli A; Massironi A; Menasce D; Miccio V; Moroni L; Negri P; Paganoni M; Pedrini D; Ragazzi S; Redaelli N; Sala S; Salerno R; Tabarelli de Fatis T; Tancini V; Taroni S; Buontempo S; Cimmino A; De Cosa A; De Gruttola M; Fabozzi F; Iorio AOM; Lista L; Noli P; Paolucci P; Azzi P; Bacchetta N; Bellan P; Bellato M; Biasotto M; Bisello D; Carlin R; Checchia P; De Mattia M; Dorigo T; Fanzago F; Gasparini F; Giubilato P; Gresele A; Lacaprara S; Lazzizzera I; Margoni M; Maron G; Meneguzzo AT; Nespolo M; Perrozzi L; Pozzobon N; Ronchese P; Simonetto F; Torassa E; Tosi M; Triossi A; Vanini S; Zumerle G; Baesso P; Berzano U; Riccardi C; Torre P; Vitulo P; Viviani C; Biasini M; Bilei GM; Caponeri B; Fanò L; Lariccia P; Lucaroni A; Mantovani G; Menichelli M; Nappi A; Santocchia A; Servoli L; Valdata M; Volpe R; Azzurri P; Bagliesi G; Bernardini J; Boccali T; Castaldi R; Dagnolo RT; Dell'Orso R; Fiori F; Foà L; Giassi A; Kraan A; Ligabue F; Lomtadze T; Martini L; Messineo A; Palla F; Palmonari F; Segneri G; Serban AT; Spagnolo P; Tenchini R; Tonelli G; Venturi A; Verdini PG; Barone L; Cavallari F; Del Re D; Di Marco E; Diemoz M; Franci D; Grassi M; Longo E; Organtini G; Palma A; Pandolfi F; Paramatti R; Rahatlou S; Amapane N; Arcidiacono R; Argiro S; Arneodo M; Biino C; Botta C; Cartiglia N; Castello R; Costa M; Demaria N; Graziano A; Mariotti C; Marone M; Maselli S; Migliore E; Mila G; Monaco V; Musich M; Obertino MM; Pastrone N; Pelliccioni M; Romero A; Ruspa M; Sacchi R; Solano A; Staiano A; Trocino D; Vilela Pereira A; Ambroglini F; Belforte S; Cossutti F; Della Ricca G; Gobbo B; Montanino D; Penzo A; Chang S; Chung J; Kim DH; Kim GN; Kim JE; Kong DJ; Park H; Son DC; Kim Z; Kim JY; Song S; Hong B; Kim H; Kim JH; Kim TJ; Lee KS; Moon DH; Park SK; Rhee HB; Sim KS; Choi M; Kang S; Kim H; Park C; Park IC; Park S; Choi S; Choi Y; Choi YK; Goh J; Lee J; Lee S; Seo H; Yu I; Janulis M; Martisiute D; Petrov P; Sabonis T; Castilla Valdez H; De La Cruz Burelo E; Lopez-Fernandez R; Sánchez Hernández A; Villaseñor-Cendejas LM; Carrillo Moreno S; Salazar Ibarguen HA; Casimiro Linares E; Morelos Pineda A; Reyes-Santos MA; Allfrey P; Krofcheck D; Tam J; Aumeyr T; Butler PH; Signal T; Williams JC; Ahmad M; Ahmed I; Asghar MI; Hoorani HR; Khan WA; Khurshid T; Qazi S; Cwiok M; Dominik W; Doroba K; Konecki M; Krolikowski J; Frueboes T; Gokieli R; Górski M; Kazana M; Nawrocki K; Szleper M; Wrochna G; Zalewski P; Almeida N; David A; Faccioli P; Ferreira Parracho PG; Gallinaro M; Mini G; Musella P; Nayak A; Raposo L; Ribeiro PQ; Seixas J; Silva P; Soares D; Varela J; Wöhri HK; Altsybeev I; Belotelov I; 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CMS Collaboration
    Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at square root of s = 7  TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN(ch)/dη|(|η|<0.5) = 5.78 ± 0.01(stat) ± 0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from square root of s = 0.9 to 7 TeV is [66.1 ± 1.0(stat) ± 4.2(syst)]%. The mean transverse momentum is measured to be 0.545 ± 0.005(stat) ± 0.015(syst)  GeV/c. The results are compared with similar measurements at lower energies.