Browsing by Author "Wang M"

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    Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
    (Springer Nature, 2023-10-02) Thomas M; Su Y-R; Rosenthal EA; Sakoda LC; Schmit SL; Timofeeva MN; Chen Z; Fernandez-Rozadilla C; Law PJ; Murphy N; Carreras-Torres R; Diez-Obrero V; van Duijnhoven FJB; Jiang S; Shin A; Wolk A; Phipps AI; Burnett-Hartman A; Gsur A; Chan AT; Zauber AG; Wu AH; Lindblom A; Um CY; Tangen CM; Gignoux C; Newton C; Haiman CA; Qu C; Bishop DT; Buchanan DD; Crosslin DR; Conti DV; Kim D-H; Hauser E; White E; Siegel E; Schumacher FR; Rennert G; Giles GG; Hampel H; Brenner H; Oze I; Oh JH; Lee JK; Schneider JL; Chang-Claude J; Kim J; Huyghe JR; Zheng J; Hampe J; Greenson J; Hopper JL; Palmer JR; Visvanathan K; Matsuo K; Matsuda K; Jung KJ; Li L; Le Marchand L; Vodickova L; Bujanda L; Gunter MJ; Matejcic M; Jenkins MA; Slattery ML; D'Amato M; Wang M; Hoffmeister M; Woods MO; Kim M; Song M; Iwasaki M; Du M; Udaltsova N; Sawada N; Vodicka P; Campbell PT; Newcomb PA; Cai Q; Pearlman R; Pai RK; Schoen RE; Steinfelder RS; Haile RW; Vandenputtelaar R; Prentice RL; Küry S; Castellví-Bel S; Tsugane S; Berndt SI; Lee SC; Brezina S; Weinstein SJ; Chanock SJ; Jee SH; Kweon S-S; Vadaparampil S; Harrison TA; Yamaji T; Keku TO; Vymetalkova V; Arndt V; Jia W-H; Shu X-O; Lin Y; Ahn Y-O; Stadler ZK; Van Guelpen B; Ulrich CM; Platz EA; Potter JD; Li CI; Meester R; Moreno V; Figueiredo JC; Casey G; Lansdorp Vogelaar I; Dunlop MG; Gruber SB; Hayes RB; Pharoah PDP; Houlston RS; Jarvik GP; Tomlinson IP; Zheng W; Corley DA; Peters U; Hsu L
    Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
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    Dietary Supplementation of Yeast Culture Into Pelleted Total Mixed Rations Improves the Growth Performance of Fattening Lambs
    (Frontiers Media S.A., 2021-05) Song B; Wu T; You P; Wang H; Burke JL; Kang K; Yu W; Wang M; Li B; He Y; Huo Q; Li C; Tian W; Li R; Li J; Wang C; Sun X
    There is a growing interest in the use of yeast (Saccharomyces cerevisiae) culture (YC) for the enhancement of growth performance and general animal health. Grain-based pelleted total mixed rations (TMR) are emerging in intensive sheep farming systems, but it is uncertain if the process of pelleting results in YC becoming ineffective. This study aimed to examine the effects of YC supplemented to pelleted TMR at two proportions of corn in the diet on animal performance, feed digestion, blood parameters, rumen fermentation, and microbial community in fattening lambs. A 2 × 2 factorial design was adopted with two experimental factors and two levels in each factor, resulting in four treatments: (1) low proportion of corn in the diet (LC; 350 g corn/kg diet) without YC, (2) LC with YC (5 g/kg diet), (3) high proportion of corn in the diet (HC; 600 g corn/kg diet) without YC, and (4) HC with YC. Fifty-six 3-month-old male F2 hybrids of thin-tailed sheep and Northeast fine-wool sheep with a liveweight of 19.9 ± 2.7 kg were randomly assigned to the four treatment groups with an equal number of animals in each group. The results showed that live yeast cells could not survive during pelleting, and thus, any biological effects of the YC were the result of feeding dead yeast and the metabolites of yeast fermentation rather than live yeast cells. The supplementation of YC resulted in 31.1 g/day more average daily gain regardless of the proportion of corn in the diet with unchanged feed intake during the 56-day growth measurement period. The digestibility of neutral detergent fibre and acid detergent fibre was increased, but the digestibility of dry matter, organic matter, and crude protein was not affected by YC. The supplementation of YC altered the rumen bacterial population and species, but the most abundant phyla Bacteroidetes, Firmicutes, and Proteobacteria remained unchanged. This study indicates that YC products can be supplemented to pelleted TMR for improved lamb growth performance, although live yeast cells are inactive after pelleting. The improved performance could be attributed to improved fibre digestibility.
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    Different effects of grazing and nitrogen addition on ecosystem multifunctionality are driven by changes in plant resource stoichiometry in a typical steppe
    (5/08/2022) Li L; He XZ; Zhang X; Hu J; Wang M; Wang Z; Hou F
    Purpose: Herbivore grazing and nitrogen (N) input may alter the multiple ecosystem functions (i.e., multifunctionality, hereafter) associated with carbon (C), N, and phosphorus (P) cycling. Most studies on variations in plant diversity, soil biotic or abiotic factors, and linkages to ecosystem functions have focused on grazing or N enrichment alone. Few studies have combined these two factors to explore the role of plant resource stoichiometry (C:N:P ratios) in ecosystem multifunctionality (EMF) control. Here, we evaluated the direct and indirect effects of stocking rate (0, 2.7, 5.3, and 8.7 sheep ha− 1) and N addition rate (0, 5, 10, and 20 g N m− 2 yr− 1) on a range of ecosystem functions and EMF via changing plant diversity, soil pH and plant resource stoichiometry in a typical steppe on the Loess Plateau. Results: We found that increasing stocking rate and interaction between grazing and N addition significantly decreased EMF, while increasing N addition rate significantly promoted EMF. Grazing decreased soil NH4+-N, soil NO3−-N, aboveground biomass, and plant C, N, and P pools, but increased soil total N and P at 8.7 and 5.3 sheep ha− 1, respectively. N addition increased soil NH4+-N, NO3−-N, and total P. Plant aboveground biomass, and plant C, N, and P pools increased at the lower N addition rate (≤ 5 g N m− 2 yr− 1) under grazing. The structural equation models indicated that (1) EMF was driven by the direct effects of grazing and the indirect effects of grazing on plant resource stoichiometry and soil pH; (2) EMF increased with increasing N addition rates, but such positive response of EMF to increasing N addition rates was alleviated at high levels of plant resource stoichiometry and diversity; and (3) the indirect effects of plant diversity induced by grazing and N addition had moderate effects on EMF via the variations of plant resource stoichiometry. Conclusions: This study demonstrated grazing and N addition had contrasting effects on ecosystem multifunctionality in a typical steppe, and highlighted the capacity of plant diversity in balancing plant elements that serve as a key mechanism in the maintenance of EMF in response to intensive grazing and N enrichment.
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    Re-entry cultural adaptation of foreign-educated academics at Chinese universities
    (Immigrantinstitutet, 1/12/2020) Li M; Croucher S; Wang M
    This study investigates the re-entry acculturative experiences and challenges facing foreign-educated returnees working at Chinese universities. Fifteen returnees from five universities in a southwestern province of China participated in semi-structured interviews. The study, using the ABC theoretical framework, highlights the acculturative process of returned academics in terms of role expectations, transformed identities, and cultural learning. The process involves challenges and unmet expectations, including low salaries, heavy workloads, unsupportive administrative bureaucracy, political control, and lack of a healthy academic community culture. The findings show that re-entry acculturation is a never-ending process. Returnees need constantly to realign their expectations and to negotiate and reinterpret shifting realities.
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    Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV.
    (AMER PHYSICAL SOC, 9/07/2010) Khachatryan V; Sirunyan AM; Tumasyan A; Adam W; Bergauer T; Dragicevic M; Erö J; Fabjan C; Friedl M; Frühwirth R; Ghete VM; Hammer J; Hänsel S; Hoch M; Hörmann N; Hrubec J; Jeitler M; Kasieczka G; Kiesenhofer W; Krammer M; Liko D; Mikulec I; Pernicka M; Rohringer H; Schöfbeck R; Strauss J; Taurok A; Teischinger F; Waltenberger W; Walzel G; Widl E; Wulz C-E; Mossolov V; Shumeiko N; Suarez Gonzalez J; Benucci L; Ceard L; De Wolf EA; Hashemi M; Janssen X; Maes T; Mucibello L; Ochesanu S; Roland B; Rougny R; Selvaggi M; Van Haevermaet H; Van Mechelen P; Van Remortel N; Adler V; Beauceron S; Blyweert S; D'Hondt J; Devroede O; Kalogeropoulos A; Maes J; Maes M; Tavernier S; Van Doninck W; Van Mulders P; Villella I; Chabert EC; Charaf O; Clerbaux B; De Lentdecker G; Dero V; Gay APR; Hammad GH; Marage PE; Vander Velde C; Vanlaer P; Wickens J; Costantini S; Grunewald M; Klein B; Marinov A; Ryckbosch D; Thyssen F; Tytgat M; Vanelderen L; Verwilligen P; Walsh S; Zaganidis N; Basegmez S; Bruno G; Caudron J; De Favereau De Jeneret J; Delaere C; Demin P; Favart D; Giammanco A; Grégoire G; Hollar J; Lemaitre V; Militaru O; Ovyn S; Pagano D; Pin A; Piotrzkowski K; Quertenmont L; Schul N; Beliy N; Caebergs T; Daubie E; Alves GA; Pol ME; Souza MHG; Carvalho W; Da Costa EM; De Jesus Damiao D; De Oliveira Martins C; Fonseca De Souza S; Mundim L; Oguri V; Santoro A; Silva Do Amaral SM; Sznajder A; Torres Da Silva De Araujo F; Dias FA; Dias MAF; Fernandez Perez Tomei TR; Gregores EM; Marinho F; Novaes SF; Padula SS; Darmenov N; Dimitrov L; Genchev V; Iaydjiev P; Piperov S; Stoykova S; Sultanov G; Trayanov R; Vankov I; Dyulendarova M; Hadjiiska R; Kozhuharov V; Litov L; Marinova E; Mateev M; Pavlov B; Petkov P; Bian JG; Chen GM; Chen HS; Jiang CH; Liang D; Liang S; Wang J; Wang J; Wang X; Wang Z; Yang M; Zang J; Zhang Z; Ban Y; Guo S; Hu Z; Mao Y; Qian SJ; Teng H; Zhu B; Cabrera A; Carrillo Montoya CA; Gomez Moreno B; Ocampo Rios AA; Osorio Oliveros AF; Sanabria JC; Godinovic N; Lelas D; Lelas K; Plestina R; Polic D; Puljak I; Antunovic Z; Dzelalija M; Brigljevic V; Duric S; Kadija K; Morovic S; Attikis A; Fereos R; Galanti M; Mousa J; Nicolaou C; Papadakis A; Ptochos F; Razis PA; Rykaczewski H; Tsiakkouri D; Zinonos Z; Mahmoud M; Hektor A; Kadastik M; Kannike K; Müntel M; Raidal M; Rebane L; Azzolini V; Eerola P; Czellar S; Härkönen J; Heikkinen A; Karimäki V; Kinnunen R; Klem J; Kortelainen MJ; Lampén T; Lassila-Perini K; Lehti S; Lindén T; Luukka P; Mäenpää T; Tuominen E; Tuominiemi J; Tuovinen E; Ungaro D; Wendland L; Banzuzi K; Korpela A; Tuuva T; Sillou D; Besancon M; Dejardin M; Denegri D; Descamps J; Fabbro B; Faure JL; Ferri F; Ganjour S; Gentit FX; Givernaud A; Gras P; Hamel de Monchenault G; Jarry P; Locci E; Malcles J; Marionneau M; Millischer L; Rander J; Rosowsky A; Rousseau D; Titov M; Verrecchia P; Baffioni S; Bianchini L; Bluj M; Broutin C; Busson P; Charlot C; Dobrzynski L; Elgammal S; Granier de Cassagnac R; Haguenauer M; Kalinowski A; Miné P; Paganini P; Sabes D; Sirois Y; Thiebaux C; Zabi A; Agram J-L; Besson A; Bloch D; Bodin D; Brom J-M; Cardaci M; Conte E; Drouhin F; Ferro C; Fontaine J-C; Gelé D; Goerlach U; Greder S; Juillot P; Karim M; Le Bihan A-C; Mikami Y; Speck J; Van Hove P; Fassi F; Mercier D; Baty C; Beaupere N; Bedjidian M; Bondu O; Boudoul G; Boumediene D; Brun H; Chanon N; Chierici R; Contardo D; Depasse P; El Mamouni H; Fay J; Gascon S; Ille B; Kurca T; Le Grand T; Lethuillier M; Mirabito L; Perries S; Tosi S; Tschudi Y; Verdier P; Xiao H; Roinishvili V; Anagnostou G; Edelhoff M; Feld L; Heracleous N; Hindrichs O; Jussen R; Klein K; Merz J; Mohr N; Ostapchuk A; Perieanu A; Raupach F; Sammet J; Schael S; Sprenger D; Weber H; Weber M; Wittmer B; Actis O; Ata M; Bender W; Biallass P; Erdmann M; Frangenheim J; Hebbeker T; Hinzmann A; Hoepfner K; Hof C; Kirsch M; Klimkovich T; Kreuzer P; Lanske D; Magass C; Merschmeyer M; Meyer A; Papacz P; Pieta H; Reithler H; Schmitz SA; Sonnenschein L; Sowa M; Steggemann J; Teyssier D; Zeidler C; Bontenackels M; Davids M; Duda M; Flügge G; Geenen H; Giffels M; Haj Ahmad W; Heydhausen D; Kress T; Kuessel Y; Linn A; Nowack A; Perchalla L; Pooth O; Sauerland P; Stahl A; Thomas M; Tornier D; Zoeller MH; Aldaya Martin M; Behrenhoff W; Behrens U; Bergholz M; Borras K; Campbell A; Castro E; Dammann D; Eckerlin G; Flossdorf A; Flucke G; Geiser A; Hauk J; Jung H; Kasemann M; Katkov I; Kleinwort C; Kluge H; Knutsson A; Kuznetsova E; Lange W; Lohmann W; Mankel R; Marienfeld M; Melzer-Pellmann I-A; Meyer AB; Mnich J; Mussgiller A; Olzem J; Parenti A; Raspereza A; Schmidt R; Schoerner-Sadenius T; Sen N; Stein M; Tomaszewska J; Volyanskyy D; Wissing C; Autermann C; Draeger J; Eckstein D; Enderle H; Gebbert U; Kaschube K; Kaussen G; Klanner R; Mura B; Naumann-Emme S; Nowak F; Sander C; Schettler H; Schleper P; Schröder M; Schum T; Schwandt J; Stadie H; Steinbrück G; Thomsen J; Wolf R; Bauer J; Buege V; Cakir A; Chwalek T; Daeuwel D; De Boer W; Dierlamm A; Dirkes G; Feindt M; Gruschke J; Hackstein C; Hartmann F; Heinrich M; Held H; Hoffmann KH; Honc S; Kuhr T; Martschei D; Mueller S; Müller T; Niegel M; Oberst O; Oehler A; Ott J; Peiffer T; Piparo D; Quast G; Rabbertz K; Ratnikov F; Renz M; Sabellek A; Saout C; Scheurer A; Schieferdecker P; Schilling F-P; Schott G; Simonis HJ; Stober FM; Troendle D; Wagner-Kuhr J; Zeise M; Zhukov V; Ziebarth EB; Daskalakis G; Geralis T; Kyriakis A; Loukas D; Manolakos I; Markou A; Markou C; Mavrommatis C; Petrakou E; Gouskos L; Katsas P; Panagiotou A; Evangelou I; Kokkas P; Manthos N; Papadopoulos I; Patras V; Triantis FA; Aranyi A; Bencze G; Boldizsar L; Debreczeni G; Hajdu C; Horvath D; Kapusi A; Krajczar K; Laszlo A; Sikler F; Vesztergombi G; Beni N; Molnar J; Palinkas J; Szillasi Z; Veszpremi V; Raics P; Trocsanyi ZL; Ujvari B; Bansal S; Beri SB; Bhatnagar V; Jindal M; Kaur M; Kohli JM; Mehta MZ; Nishu N; Saini LK; Sharma A; Sharma R; Singh AP; Singh JB; Singh SP; Ahuja S; Bhattacharya S; Chauhan S; Choudhary BC; Gupta P; Jain S; Jain S; Kumar A; Ranjan K; Shivpuri RK; Choudhury RK; Dutta D; Kailas S; Kataria SK; Mohanty AK; Pant LM; Shukla P; Suggisetti P; Aziz T; Guchait M; Gurtu A; Maity M; Majumder D; Majumder G; Mazumdar K; Mohanty GB; Saha A; Sudhakar K; Wickramage N; Banerjee S; Dugad S; Mondal NK; Arfaei H; Bakhshiansohi H; Fahim A; Jafari A; Mohammadi Najafabadi M; Paktinat Mehdiabadi S; Safarzadeh B; Zeinali M; Abbrescia M; Barbone L; Colaleo A; Creanza D; De Filippis N; De Palma M; Dimitrov A; Fedele F; Fiore L; Iaselli G; Lusito L; Maggi G; Maggi M; Manna N; Marangelli B; My S; Nuzzo S; Pierro GA; Pompili A; Pugliese G; Romano F; Roselli G; Selvaggi G; Silvestris L; Trentadue R; Tupputi S; Zito G; Abbiendi G; Benvenuti AC; Bonacorsi D; Braibant-Giacomelli S; Castro A; Cavallo FR; Codispoti G; Dallavalle GM; Fabbri F; Fanfani A; Fasanella D; Giacomelli P; Giunta M; Grandi C; Marcellini S; Masetti G; Montanari A; Navarria FL; Odorici F; Perrotta A; Rossi AM; Rovelli T; Siroli G; Travaglini R; Albergo S; Cappello G; Chiorboli M; Costa S; Tricomi A; Tuve C; Barbagli G; Broccolo G; Ciulli V; Civinini C; D'Alessandro R; Focardi E; Frosali S; Gallo E; Genta C; Lenzi P; Meschini M; Paoletti S; Sguazzoni G; Tropiano A; Benussi L; Bianco S; Colafranceschi S; Fabbri F; Piccolo D; Fabbricatore P; Musenich R; Benaglia A; Cerati GB; De Guio F; Di Matteo L; Ghezzi A; Govoni P; Malberti M; Malvezzi S; Martelli A; Massironi A; Menasce D; Miccio V; Moroni L; Negri P; Paganoni M; Pedrini D; Ragazzi S; Redaelli N; Sala S; Salerno R; Tabarelli de Fatis T; Tancini V; Taroni S; Buontempo S; Cimmino A; De Cosa A; De Gruttola M; Fabozzi F; Iorio AOM; Lista L; Noli P; Paolucci P; Azzi P; Bacchetta N; Bellan P; Bellato M; Biasotto M; Bisello D; Carlin R; Checchia P; De Mattia M; Dorigo T; Fanzago F; Gasparini F; Giubilato P; Gresele A; Lacaprara S; Lazzizzera I; Margoni M; Maron G; Meneguzzo AT; Nespolo M; Perrozzi L; Pozzobon N; Ronchese P; Simonetto F; Torassa E; Tosi M; Triossi A; Vanini S; Zumerle G; Baesso P; Berzano U; Riccardi C; Torre P; Vitulo P; Viviani C; Biasini M; Bilei GM; Caponeri B; Fanò L; Lariccia P; Lucaroni A; Mantovani G; Menichelli M; Nappi A; Santocchia A; Servoli L; Valdata M; Volpe R; Azzurri P; Bagliesi G; Bernardini J; Boccali T; Castaldi R; Dagnolo RT; Dell'Orso R; Fiori F; Foà L; Giassi A; Kraan A; Ligabue F; Lomtadze T; Martini L; Messineo A; Palla F; Palmonari F; Segneri G; Serban AT; Spagnolo P; Tenchini R; Tonelli G; Venturi A; Verdini PG; Barone L; Cavallari F; Del Re D; Di Marco E; Diemoz M; Franci D; Grassi M; Longo E; Organtini G; Palma A; Pandolfi F; Paramatti R; Rahatlou S; Amapane N; Arcidiacono R; Argiro S; Arneodo M; Biino C; Botta C; Cartiglia N; Castello R; Costa M; Demaria N; Graziano A; Mariotti C; Marone M; Maselli S; Migliore E; Mila G; Monaco V; Musich M; Obertino MM; Pastrone N; Pelliccioni M; Romero A; Ruspa M; Sacchi R; Solano A; Staiano A; Trocino D; Vilela Pereira A; Ambroglini F; Belforte S; Cossutti F; Della Ricca G; Gobbo B; Montanino D; Penzo A; Chang S; Chung J; Kim DH; Kim GN; Kim JE; Kong DJ; Park H; Son DC; Kim Z; Kim JY; Song S; Hong B; Kim H; Kim JH; Kim TJ; Lee KS; Moon DH; Park SK; Rhee HB; Sim KS; Choi M; Kang S; Kim H; Park C; Park IC; Park S; Choi S; Choi Y; Choi YK; Goh J; Lee J; Lee S; Seo H; Yu I; Janulis M; Martisiute D; Petrov P; Sabonis T; Castilla Valdez H; De La Cruz Burelo E; Lopez-Fernandez R; Sánchez Hernández A; Villaseñor-Cendejas LM; Carrillo Moreno S; Salazar Ibarguen HA; Casimiro Linares E; Morelos Pineda A; Reyes-Santos MA; Allfrey P; Krofcheck D; Tam J; Aumeyr T; Butler PH; Signal T; Williams JC; Ahmad M; Ahmed I; Asghar MI; Hoorani HR; Khan WA; Khurshid T; Qazi S; Cwiok M; Dominik W; Doroba K; Konecki M; Krolikowski J; Frueboes T; Gokieli R; Górski M; Kazana M; Nawrocki K; Szleper M; Wrochna G; Zalewski P; Almeida N; David A; Faccioli P; Ferreira Parracho PG; Gallinaro M; Mini G; Musella P; Nayak A; Raposo L; Ribeiro PQ; Seixas J; Silva P; Soares D; Varela J; Wöhri HK; Altsybeev I; Belotelov I; Bunin P; Finger M; Finger M; Golutvin I; Kamenev A; Karjavin V; Kozlov G; Lanev A; Moisenz P; Palichik V; Perelygin V; Shmatov S; Smirnov V; Volodko A; Zarubin A; Bondar N; Golovtsov V; Ivanov Y; Kim V; Levchenko P; Smirnov I; Sulimov V; Uvarov L; Vavilov S; Vorobyev A; Andreev Y; Gninenko S; Golubev N; Kirsanov M; Krasnikov N; Matveev V; Pashenkov A; Toropin A; Troitsky S; Epshteyn V; Gavrilov V; Ilina N; Kaftanov V; Kossov M; Krokhotin A; Kuleshov S; Oulianov A; Safronov G; Semenov S; Shreyber I; Stolin V; Vlasov E; Zhokin A; Boos E; Dubinin M; Dudko L; Ershov A; Gribushin A; Kodolova O; Lokhtin I; Obraztsov S; Petrushanko S; Sarycheva L; Savrin V; Snigirev A; Andreev V; Dremin I; Kirakosyan M; Rusakov SV; Vinogradov A; Azhgirey I; Bitioukov S; Datsko K; Grishin V; Kachanov V; Konstantinov D; Krychkine V; Petrov V; Ryutin R; Slabospitsky S; Sobol A; Sytine A; Tourtchanovitch L; Troshin S; Tyurin N; Uzunian A; Volkov A; Adzic P; Djordjevic M; Krpic D; Maletic D; Milosevic J; Puzovic J; 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CMS Collaboration
    Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at square root of s = 7  TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN(ch)/dη|(|η|<0.5) = 5.78 ± 0.01(stat) ± 0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from square root of s = 0.9 to 7 TeV is [66.1 ± 1.0(stat) ± 4.2(syst)]%. The mean transverse momentum is measured to be 0.545 ± 0.005(stat) ± 0.015(syst)  GeV/c. The results are compared with similar measurements at lower energies.
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    Whole-genome resequencing of the native sheep provides insights into the microevolution and identifies genes associated with reproduction traits
    (BioMed Central Ltd, 2023-07-11) Zhu M; Yang Y; Yang H; Zhao Z; Zhang H; Blair HT; Zheng W; Wang M; Fang C; Yu Q; Zhou H; Qi H
    BACKGROUND: Sheep genomes undergo numerous genes losses, gains and mutation that generates genome variability among breeds of the same species after long time natural and artificial selection. However, the microevolution of native sheep in northwest China remains elusive. Our aim was to compare the genomes and relevant reproductive traits of four sheep breeds from different climatic environments, to unveil the selection challenges that this species cope with, and the microevolutionary differences in sheep genomes. Here, we resequenced the genomes of 4 representative sheep breeds in northwest China, including Kazakh sheep and Duolang sheep of native breeds, and Hu sheep and Suffolk sheep of exotic breeds with different reproductive characteristics. RESULTS: We found that these four breeds had a similar expansion experience from ~ 10,000 to 1,000,000 years ago. In the past 10,000 years, the selection intensity of the four breeds was inconsistent, resulting in differences in reproductive traits. We explored the sheep variome and selection signatures by FST and θπ. The genomic regions containing genes associated with different reproductive traits that may be potential targets for breeding and selection were detected. Furthermore, non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds with different reproductive characteristics were found. We identified PAK1, CYP19A1 and PER1 as a likely causal gene for seasonal reproduction in native sheep through qPCR, Western blot and ELISA analyses. Also, the haplotype frequencies of 3 tested gene regions related to reproduction were significantly different among four sheep breeds. CONCLUSIONS: Our results provide insights into the microevolution of native sheep and valuable genomic information for identifying genes associated with important reproductive traits in sheep.