Njoroge JWPhonphimai PKhatmorn PKetnawa STonkla PVong VSingh JKaur LDonlao N2025-11-182025-12Njoroge JW, Phonphimai P, Khatmorn P, Ketnawa S, Tonkla P, Vong V, Singh J, Kaur L, Donlao N. (2025). Valorization of Sacha Inchi press cake: Technological advances, market, and regulatory considerations for sustainable food applications. Food Chemistry Advances. 9.2772-753Xhttps://mro.massey.ac.nz/handle/10179/73841Sacha Inchi (Plukenetia volubilis L.) press cake (SP), the nutrient-dense by-product of oil extraction, is rich in high quality proteins, essential fatty acids, and bioactive compounds. However, its use remains constrained by processing, regulatory and market acceptance barriers. This review summarizes recent advances in processing strategies to improve SP's nutritional, functional, and sensory qualities. Physical treatments (dry/wet fractionation, steaming, autoclaving, roasting and extrusion) increase protein digestibility and solubility while reducing heat-stable antinutrients. Emerging methods, including high-pressure processing, high-pressure homogenization, ultrasonication, microwave treatment, electroconductivity (Ohmic/PEF), and cold plasma technologies enhance extractability and bioactivity while preserving sensitive compounds. Chemical and chemo-enzymatic approaches (e.g., alkaline soaking, cyclodextrin complexation) suppress flavor precursors, whereas enzymatic hydrolysis and fermentation improve bioactive peptide release, digestibility, and functionality. Functional additives (sweeteners, salts, polysaccharides, flavor enhancers) help mask bitterness, while paired with consumer-preferred flavors increase acceptance. Beyond processing, safety approvals (e.g., Thai FDA, EU novel food approval) and consumer perception on sensory, nutritional, and sustainability factors shape its market potential. Currently, SP shows potential across a wide range of food applications and its valorization supports sustainable protein supply chains. Future opportunities depend on integrating processing, safety, and regulatory strategies with consumer-driven innovation.CC BY-NC-ND 4.0(c) 2025 The Author/shttps://creativecommons.org/licenses/by-nc-nd/4.0/AntinutrientsBioprocessingFermentationFunctional propertiesPhysical technologiesSacha Inchi press cakeSustainabilityJournal article10.1016/j.focha.2025.1011512772-753Xjournal-article101151S2772753X25002618