Gong JHarris KLipnicki DMCastro-Costa ELima-Costa MFDiniz BSXiao SLipton RBKatz MJWang CPreux P-MGuerchet MGbessemehlan ARitchie KAncelin M-LSkoog INajar JSterner TRScarmeas NYannakoulia MKosmidis MHGuaita ARolandi EDavin AGureje OTrompet SGussekloo JRiedel-Heller SPabst ARöhr SShahar SSingh DKARivan NFMBoxtel MVKöhler SGanguli MChang C-CJacobsen EHaan MDing DZhao QNarazaki KChen TChen SNg TPGwee XNumbers KMather KAScazufca MLobo ADe-la-Cámara CLobo ESachdev PSBrodaty HHackett MLPeters SAEWoodward M2024-05-152024-05-152023-08-01Gong J, Harris K, Lipnicki DM, Castro-Costa E, Lima-Costa MF, Diniz BS, Xiao S, Lipton RB, Katz MJ, Wang C, Preux P-M, Guerchet M, Gbessemehlan A, Ritchie K, Ancelin M-L, Skoog I, Najar J, Sterner TR, Scarmeas N, Yannakoulia M, Kosmidis MH, Guaita A, Rolandi E, Davin A, Gureje O, Trompet S, Gussekloo J, Riedel-Heller S, Pabst A, Röhr S, Shahar S, Singh DKA, Rivan NFM, Boxtel MV, Köhler S, Ganguli M, Chang C-C, Jacobsen E, Haan M, Ding D, Zhao Q, Xiao Z, Narazaki K, Chen T, Chen S, Ng TP, Gwee X, Numbers K, Mather KA, Scazufca M, Lobo A, De-la-Cámara C, Lobo E, Sachdev PS, Brodaty H, Hackett ML, Peters SAE, Woodward M, Cohort Studies of Memory in an International Consortium (COSMIC) . (2023). Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.. Alzheimers Dement. 19. 8. (pp. 3365-3378).1552-5260https://mro.massey.ac.nz/handle/10179/69566INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.(c) 2023 The Author/sCC BY 4.0https://creativecommons.org/licenses/by/4.0/data harmonizationdementiadiversityrisk factorsex differenceHumansMaleFemaleSex CharacteristicsRisk FactorsAlcohol DrinkingDementiaSex FactorsJournal article10.1002/alz.129621552-5279journal-article3365-3378https://www.ncbi.nlm.nih.gov/pubmed/36790027