Balcomb CCHeller MCChigerwe MKnych HKMeyer AM2024-08-142024-08-142018-05-01Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. (2018). Pharmacokinetics and efficacy of intravenous famotidine in adult cattle.. J Vet Intern Med. 32. 3. (pp. 1283-1289).0891-6640https://mro.massey.ac.nz/handle/10179/71286BACKGROUND: Abomasal ulceration is recognized in neonatal and adult cattle, but research regarding treatment is limited. Histamine-2 receptor antagonists (H2 RA), such as famotidine, are used clinically with little evidence-based research about efficacy in adult cattle. HYPOTHESIS AND OBJECTIVES: Intravenous famotidine administered at 0.4 mg/kg will increase the pH of abomasal outflow digesta compared to saline control in adult cattle. The objectives were to assess the effect of famotidine, administered as a single dose and as multiple doses, on abomasal outflow fluid pH in adult cattle. A third objective was to describe the pharmacokinetic parameters of IV famotidine in cattle. ANIMALS: Four clinically healthy adult Angus-cross steers previously fitted with duodenal cannulae placed orad to the biliary and pancreatic ducts. METHODS: Randomized, 2-way cross-over clinical trial. Steers received IV famotidine (0.4 mg/kg) as a single and 3-dose regimen (every 8 hours) versus saline control. Blood for analysis of serum famotidine concentration was collected intermittently for 12 hours, and abomasal outflow fluid pH was measured at intervals for a 24-hour period. After a 34-hour washout period, the opposite treatments were administered and the sampling repeated. RESULTS: Abomasal outflow fluid pH was higher in steers treated with famotidine for up to 4 hours after a single dose but the effect decreased with subsequent doses. The median (range) elimination half-life was 3.33 (3.21-3.54) hours. CONCLUSIONS AND CLINICAL IMPORTANCE: Famotidine may be useful for treatment or prevention of abomasal ulceration in adult cattle, but the duration of effect may decrease with time.(c) 2018 The Author/shttps://creativecommons.org/licenses/by/4.0/abomasumbovinegastroprotectantulcerAbomasumAnimalsCattleCross-Over StudiesDrug Administration ScheduleFamotidineHistamine H2 AntagonistsHydrogen-Ion ConcentrationInjections, IntravenousMaleJournal article10.1111/jvim.150801939-1676journal-article1283-1289https://www.ncbi.nlm.nih.gov/pubmed/29572958