Cornelio JTelfer SG2024-01-112024-07-252022-05-232024-01-112024-07-252022-06-15Cornelio J, Telfer SG. (2022). Tuning the Stereoselectivity of an Intramolecular Aldol Reaction by Precisely Modifying a Metal-Organic Framework Catalyst.. Chem Asian J. 17. 12. (pp. e202200243-).1861-4728https://mro.massey.ac.nz/handle/10179/70867We report the catalysis of an enantioselective, intramolecular aldol reaction accelerated by an organocatalyst embedded in a series of multicomponent metal-organic frameworks. By precisely programming the pore microenvironment around the site of catalysis, we show how important features of an intramolecular aldol reaction can be tuned, such as the substrate consumption, enantioselectivity, and degree of dehydration of the products. This tunability arises from non-covalent interactions between the reaction participants and modulator groups that occupy positions in the framework remote from the catalytic site. Further, the catalytic moiety can be switched form one framework linker to another. Deliberately building up microenvironments that can influence the outcome of reaction processes in this way is not possible in conventional homogenous catalysts but is reminiscent of enzymes.(c) 2022 The Author/sCC BY 4.0https://creativecommons.org/licenses/by/4.0/aldol reactionheterogenous catalysis• intramolecular reactionsmetal-organic frameworksorganocatalysisAldehydesCatalysisHumansMetal-Organic FrameworksStereoisomerismJournal article10.1002/asia.2022002431861-471Xjournal-articlee202200243-https://www.ncbi.nlm.nih.gov/pubmed/35466580e202200243