Kitson, Trevor M2025-08-182025-08-181991https://mro.massey.ac.nz/handle/10179/73374The scientific publications contained herein constitute the results of nearly twenty years of research into aldehyde dehydrogenase, disulfiram, and related topics. I came to the Department of Chemistry and Biochemistry at Massey University in January 1972 as a Post-Doctoral Fellow after having completed an M.A. (First Class Honours) in Natural Science (Chemistry) and a D. Phil. (involving enzyme kinetics and enzyme modifiction), both at Oxford. Since the years of my doctorate, I hope I have become reasonably proficient in certain biochemical techniques necessary for the study of enzymology (isolation, purification, chemical modification, kinetics, etc.), but I retain a strong interest in chemistry. Organic chemistry was my favourite subject at school and as an undergraduate, and is still my major concern as a University lecturer. Someone once said that "any competent organic chemist can do biochemistry in his spare time". That may be an exaggeration, but there is no doubt that a sure foundation in organic chemistry is extremely useful for biochemical research. It is my belief that the papers presented here illustrate several cases where a sound knowledge and an application of chemistry have corrected mistakes or clarified difficulties in my particular area of biochemical research. [From Introduction]en© The AuthorAldehyde dehydrogenaseDisulfiramThesis