Walallawita USWolber FMZiv-Gal AKruger MCHeyes JAWalallawita Kankanamge U2025-05-272025-05-272025-03-08Walallawita US, Wolber FM, Ziv-Gal A, Kruger MC, Heyes JA, Walallawita Kankanamge U. (2025). Small daily doses of orange heirloom (“Moonglow”) tomatoes dose-dependently increase plasma and liver lycopene concentrations in rats. Bioscience, Biotechnology, and Biochemistry. 89. 6. (pp. 876-883).0916-8451https://mro.massey.ac.nz/handle/10179/72948Lycopene in red tomatoes is mainly in the poorly bioavailable all-trans- isomeric form, while “Moonglow,” an orange heirloom tomato, contains more bioavailable cis-lycopene isomers. Consuming around 1.5 kg of red tomatoes daily is needed to achieve effective plasma lycopene levels (>0.45 µmol/L). This study hypothesized that small daily doses of “Moonglow” tomatoes could achieve beneficial lycopene levels in rats. Female Sprague-Dawley rats were supplemented with “Moonglow” tomato powder. In Study 1, rats received lycopene at 0, 0.05, 0.35, or 2.6 mg/kg body weight daily for five days. Plasma and liver lycopene concentrations increased dose-dependently. In Study 2, rats given 0.35 mg/kg daily showed dose- and time-dependent increases in lycopene. Plasma lycopene reached 0.42 µmol/L after 4 days, similar to beneficial human levels. These findings suggest that a reasonable daily intake of “Moonglow” tomatoes can achieve effective plasma lycopene concentrations.(c) 2025 The Author/sCC BY 4.0https://creativecommons.org/licenses/by/4.0/Journal article10.1093/bbb/zbaf0271347-6947journal-article876-883