Bray JPMunday JSDobson JHayes AHughes K2024-08-152024-08-152023-03-29Bray JP, Munday JS. (2023). Development of a Nomogram to Predict the Outcome for Patients with Soft Tissue Sarcoma.. Vet Sci. 10. 4. (pp. 266-).2306-7381https://mro.massey.ac.nz/handle/10179/71321Soft tissue sarcomas (STSs) are common cutaneous or subcutaneous neoplasms in dogs. Most STSs are initially treated by surgical excision, and local recurrence may develop in almost 20% of patients. Currently, it is difficult to predict which STS will recur after excision, but this ability would greatly assist patient management. In recent years, the nomogram has emerged as a tool to allow oncologists to predict an outcome from a combination of risk factors. The aim of this study was to develop a nomogram for canine STSs and determine if the nomogram could predict patient outcomes better than individual tumour characteristics. The current study provides the first evidence in veterinary oncology to support a role for the nomogram to assist with predicting the outcome for patients after surgery for STSs. The nomogram developed in this study accurately predicted tumour-free survival in 25 patients but failed to predict recurrence in 1 patient. Overall, the sensitivity, specificity, positive predictive, and negative predictive values for the nomogram were 96%, 45%, 45%, and 96%, respectively (area under the curve: AUC = 0.84). This study suggests a nomogram could play an important role in helping to identify patients who could benefit from revision surgery or adjuvant therapy for an STS.(c) 2023 The Author/sCC BY 4.0https://creativecommons.org/licenses/by/4.0/immunohistochemistrynomogramprognosissoft tissue sarcomaJournal article10.3390/vetsci100402662306-7381journal-article266-https://www.ncbi.nlm.nih.gov/pubmed/37104421266vetsci10040266