Oberoi AGiezenaar CRigda RSLange KHorowitz MJones KLChapman ISoenen SGropper S2023-10-172023-10-192022-07-282023-10-172023-10-192022-08Oberoi A, Giezenaar C, Rigda RS, Lange K, Horowitz M, Jones KL, Chapman I, Soenen S. (2022). Comparative Effects of Co-Ingesting Whey Protein and Glucose Alone and Combined on Blood Glucose, Plasma Insulin and Glucagon Concentrations in Younger and Older Men.. Nutrients. 14. 15. (pp. 3111-).2072-6643http://hdl.handle.net/10179/20333The ingestion of dietary protein with, or before, carbohydrate may be a useful strategy to reduce postprandial hyperglycemia, but its effect in older people, who have an increased predisposition for type 2 diabetes, has not been clarified. Blood glucose, plasma insulin and glucagon concentrations were measured for 180 min following a drink containing either glucose (120 kcal), whey-protein (120 kcal), whey-protein plus glucose (240 kcal) or control (~2 kcal) in healthy younger (n = 10, 29 ± 2 years; 26.1 ± 0.4 kg/m2) and older men (n = 10, 78 ± 2 years; 27.3 ± 1.4 kg/m2). Mixed model analysis was used. In both age groups the co-ingestion of protein with glucose (i) markedly reduced the increase in blood glucose concentrations following glucose ingestion alone (p < 0.001) and (ii) had a synergistic effect on the increase in insulin concentrations (p = 0.002). Peak insulin concentrations after protein were unaffected by ageing, whereas insulin levels after glucose were lower in older than younger men (p < 0.05) and peak insulin concentrations were higher after glucose than protein in younger (p < 0.001) but not older men. Glucagon concentrations were unaffected by age. We conclude that the ability of whey-protein to reduce carbohydrate-induced postprandial hyperglycemia is retained in older men and that protein supplementation may be a useful strategy in the prevention and management of type 2 diabetes in older people.3111-(c) 2022 The Author/sCC BYhttps://creativecommons.org/licenses/by/4.0/agingblood glucosedietary glucoseglucagoninsulinwhey proteinAgedBlood GlucoseDiabetes Mellitus, Type 2GlucagonGlucagon-Like Peptide 1GlucoseHumansHyperglycemiaInsulinMalePostprandial PeriodWhey ProteinsJournal article10.3390/nu141531112072-66432023-10-17Massey_Darkjournal-article