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Discovering links between elongation factors and general amino acid control in Saccharomyces cerevisiae : this thesis is presented in partial fulfilment of the requirements for the degree of Doctor of Philosphy (PhD) in Biochemistry at Massey University, Auckland, New Zealand.
(Massey University, 2011)
Continous protein synthesis is essential for life; hence, a steady supply of amino acids must be maintained. In order to respond appropriately to amino acid shortages, cells need to constantly monitor their availability. ...
Unravelling the genomic structure of Saccharomyces cerevisiae : a thesis submitted for the degree of Doctor of Philosophy at Massey University, Auckland, New Zealand
(Massey University, 2011)
Advances in high-throughput sequencing technology have enabled the sequencing of genomes for many organisms. But the ability to describe the linear arrangement of genetic elements on the chromosomes does not tell us much ...
Genomes in space and time : insights into the functional three-dimensional organization of prokaryotic and eukaryotic genomes in response to environmental stimuli and cell cycle progression : a thesis presented in partial fulfilment of the requirements for the degree of Doctorate in Philosophy in Genetics at Massey University, Albany, New Zealand
(Massey University, 2014)
The specific three-dimensional organization of prokaryotic and eukaryotic genomes and its contribution to cellular functions is increasingly being recognized as critical.
Bacterial chromosomes are highly condensed into ...
Shedding light on the link between the actin cytoskeleton and stress response in Saccharomyces cerevisiae : a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Massey University, Auckland, New Zealand
(Massey University, 2012)
Understanding how eukaryotic cells adapt to stress remains a fundamental
question in biology. One important stress which affects all cells is
amino acid (AA) starvation. Upon perception of AA starvation the Gcn2
protein ...
Does DNA topography coordinate intra- & inter-chromosomal Galactose gene expression? : this thesis is presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University, Albany, New Zealand
(Massey University, 2012-02-07)
For a long time, DNA had been considered as a stabilized, rigid, and “linear” structure,
which acts as a platform for molecular regulators to function. However, genome
structure in living cells is far more complex than ...
Investigating the evolutionary changes in Crabtree-negative yeasts during a long-term evolution experiment : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Genetics at Massey University, Albany, New Zealand
(Massey University, 2017)
The Crabtree effect is a metabolic strategy that allows yeast to ferment in the presence of oxygen.
This is of interest as not all yeasts display this strategy, and nearly 100 years after its discovery it
is still unclear ...
Role of the ribosomal DNA repeats on chromosome segregation of Saccharomyces cerevisiae : a dissertation presented in fulfillment of the requirements for the degree of Doctor of Philosophy in Genetics at Massey University, Albany, New Zealand
(Massey University, 2016)
Chromosome segregation is a highly conserved process that progresses with great
accuracy. Failure of proper segregation can lead to genetic disorders, such as Down syndrome in
humans. Interestingly, segregation errors ...
Identification of large ribosomal proteins required for the full activation of the protein kinase Gcn2 in Saccharomyces cerevisiae : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biologocal Sciences at Massey University, Albany, New Zealand. EMBARGOED until 24 March 2021.
(Massey University, 2019)
Protein synthesis is a fundamental biological process that all organisms require for maintaining
life, growth and development. The maintenance of amino acid levels, the building blocks of
proteins, is essential for ...