Massey Research Online
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Nanodelivery systems of thymoquinone for improving its bioavailability and efficiency in the food and biomedical applications
(Elsevier B V, 2025-10-15) Shaddel R; Rashidinejad A; Karimkhani MM; Tarhan O; Jafari SM
Thymoquinone (TQ), a hydrophobic bioactive constituent of Nigella sativa seeds, has garnered attention for its potential in treating various ailments due to its antioxidative and anti-inflammatory properties. However, TQ's hydrophobicity, instability in varying pH environments, photosensitivity, rapid hepatic metabolism, and low bioavailability present major challenges for its application in pharmaceutical and nutraceutical formulations. Nanotechnology offers innovative nanocarriers that can overcome these limitations. Notable among these are lipid-based nanocarriers (e.g., nano-liposomes, nano-emulsions, niosomes, solid lipid nanoparticles, and nanostructured lipid carriers), biopolymeric systems (e.g., nano-hydrogels, nanofibers, nanotubes, and cyclodextrin inclusion complexes), and inorganic nanocarriers. These delivery systems are designed to enhance TQ's solubility, protect it from degradation, and improve its bioavailability and therapeutic performance. Despite numerous advances, the clinical and industrial translation of these nano-delivery systems remains limited, primarily due to scalability issues, regulatory constraints, and a lack of standardized evaluation protocols for food and biomedical use. This review provides a comprehensive analysis of these nanocarriers, emphasizing their mechanisms for TQ encapsulation, controlled release, and bioaccessibility enhancement. It also highlights current limitations and outlines future directions for their development. Unlike previous reviews, this work offers a comparative evaluation of nanocarrier systems for both food and biomedical applications, addressing their effectiveness, limitations, and readiness for real-world translation. The key takeaway is that among the various approaches, lipid-based and biopolymeric nanocarriers have demonstrated the greatest potential for enhancing TQ delivery, particularly in oral and functional food formulations, as well as targeted cancer therapy, due to their biocompatibility, scalability, and effective release profiles.
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Currency digitalization: The supply, demand, and infrastructure aspects of china's central bank digital currency
(Elsevier B.V., 2025-11) Zeng L; Young MR; Hao W
This paper studies how digitalization affects the adoption of China's central bank digital currency (e-CNY). Utilizing provincial-level panel data from 2011 to 2021, we examine the impacts of "Breadth of Digitalization Coverage" and "Digitalization Level" on the supply and demand dynamics of e-CNY. Our findings show that digitalization reduces both the supply and demand of physical currency. This decreasing reliance on physical currency implies that digitalization has paved the way for adopting e-CNY. We further investigate the infrastructural factors that support digitalization progression and e-CNY's implementation. Our results suggest that the transition from physical to digital currency is jointly driven by wallet digitalization (enabled by smartphones) and payment scenario digitalization (supported by e-commerce). Our result findings provide implications to both China and other countries developing CBDC initiatives.
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Contested Development Paths and Rural Communities: Sustainable Energy or Sustainable Tourism in Iceland?
(MDPI (Basel, Switzerland), 2019-07-02) Sætórsdóttir AD; Hall CM
The Icelandic economy has transitioned from being dependent on fishing and agriculture to having tourism and refined aluminum as its main exports. Nevertheless, the new main industries still rely on the country's natural resources, as the power intensive industry uses energy from rivers and geothermal areas whereas tourism uses the natural landscape, where geysers, waterfalls and thermal pools are part of the attraction to visitors. Although both industries claim to contribute to sustainability they utilize the same resources, and land-use conflicts can be expected, illustrating the contestation that can occur between different visions and understandings of sustainability. This paper focuses on the attitudes of Icelandic tourism operators towards power production and proposed power plants using data from questionnaires and face-to-face interviews. Results show that the majority of Icelandic tourism operators assume further power utilization would be in conflict with nature-based tourism, and they are generally negative towards all types of renewable energy development and power plant infrastructure. Respondents are most negative towards transmission lines, reservoirs and hydro power plants in the country's interior Highlands. About 40% of the respondents perceive that existing power plants have negatively affected tourism, while a similar proportion think they had no impact. According to the respondents, the two industries could co-exist with improved spatial planning, management and inter-sectoral cooperation.
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Exploring CBD Retail Performance, Recovery and Resilience of a Smart City Following COVID-19
(MDPI (Basel, Switzerland), 2023-05-19) Fieger P; Prayag G; Dyason D; Rice J; Hall CM; Basbas S
The city of Christchurch, New Zealand, incurred significant damage due to a series of earthquakes in 2010 and 2011. The city had, by the late 2010s, regained economic and social normalcy after a sustained period of rebuilding and economic recovery. Through the concerted rebuilding effort, a modern central business district (CBD) with redesigned infrastructure and amenities was developed. The Christchurch rebuild was underpinned by a commitment of urban planners to an open and connected city, including the use of innovative technologies to gather, use and share data. As was the case elsewhere, the COVID-19 pandemic brought about significant disruptions to social and economic life in Christchurch. Border closures, lockdowns, trading limitations and other restrictions on movement led to changes in traditional consumer behaviors and affected the retail sector’s resilience. In this study, we used CBD pedestrian traffic data gathered from various locations to predict changes in retail spending and identify recovery implications through the lens of retail resilience. We found that the COVID-19 pandemic and its related lockdowns have driven a substantive change in the behavioral patterns of city users. The implications for resilient retail, sustainable policy and further research are explored.
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Fine mapping highlights ITGAL and MUS81 loss-of-function mutations modulating recessive impacts in dairy cattle
(John Wiley and Sons Ltd on behalf of Stichting International Foundation for Animal Genetics, 2025-08-01) Duntsch L; Jivanji S; Lopdell T; Reynolds EGM; Williams L; Littlejohn MD
We recently described several major-effect recessive loci impacting anatomical and lactation traits in dairy cattle. Two of these loci in particular presented multiple candidate causative variants, comprising tightly linked coding variants that could not be easily differentiated on a statistical or functional basis. Here, we re-examine the candidacy of these variants by leveraging a dataset of 1 million genotyped animals. Assessing lactation and bodyweight effects in conjunction with rare, recombined genotypes for the IL4R, KIAA0556, ITGAL, DPF2, and MUS81 candidates, we highlight ITGAL and MUS81 as the most likely causative genes for the two QTL. Recombinant homozygotes for these genes present larger, more significant effects than other candidates at the same loci, with both representing premature stop mutations anticipated to inactivate ITGAL and MUS81. We further examined homozygotes for the ITGAL mutation to better understand the range of phenotypes impacted. While outwardly normal, ITGAL mutants showed significant differences in the number and composition of circulating leukocytes, consistent with the role of ITGAL as a key mediator of leukocyte signalling, adhesion, and migration. These results demonstrate how near-perfectly linked candidate mutations can be differentiated given population-scale data, and highlight the ITGAL and MUS81 mutations as diagnostic targets to help manage the frequency of these variants.