Browsing by Author "Chen X"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- ItemA Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk.(American Association for Cancer Research, 2023-08-01) Aglago EK; Kim A; Lin Y; Qu C; Evangelou M; Ren Y; Morrison J; Albanes D; Arndt V; Barry EL; Baurley JW; Berndt SI; Bien SA; Bishop DT; Bouras E; Brenner H; Buchanan DD; Budiarto A; Carreras-Torres R; Casey G; Cenggoro TW; Chan AT; Chang-Claude J; Chen X; Conti DV; Devall M; Diez-Obrero V; Dimou N; Drew D; Figueiredo JC; Gallinger S; Giles GG; Gruber SB; Gsur A; Gunter MJ; Hampel H; Harlid S; Hidaka A; Harrison TA; Hoffmeister M; Huyghe JR; Jenkins MA; Jordahl K; Joshi AD; Kawaguchi ES; Keku TO; Kundaje A; Larsson SC; Marchand LL; Lewinger JP; Li L; Lynch BM; Mahesworo B; Mandic M; Obón-Santacana M; Moreno V; Murphy N; Nan H; Nassir R; Newcomb PA; Ogino S; Ose J; Pai RK; Palmer JR; Papadimitriou N; Pardamean B; Peoples AR; Platz EA; Potter JD; Prentice RL; Rennert G; Ruiz-Narvaez E; Sakoda LC; Scacheri PC; Schmit SL; Schoen RE; Shcherbina A; Slattery ML; Stern MC; Su Y-R; Tangen CM; Thibodeau SN; Thomas DC; Tian Y; Ulrich CM; van Duijnhoven FJ; Van Guelpen B; Visvanathan K; Vodicka P; Wang J; White E; Wolk A; Woods MO; Wu AH; Zemlianskaia N; Hsu L; Gauderman WJ; Peters U; Tsilidis KK; Campbell PTColorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer. Significance: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
- ItemSoil C, N, and P stocks evaluation under major land uses on China’s Loess Plateau(Society for Range Management, 2017-03-01) Chen X; Hou F; Matthew C; He XZLoess Plateau covers 640 000 km2 in the central northern China. Despite a semiarid environment, harsh winters, and hot summers, agriculture has been practiced in this region for > 5 000 yr, and the food production systems are among China's oldest. The environment is fragile because the loessial soils are prone to erosion. Sound scientific information is therefore required to underpin future land use planning in the region. To this end, total soil organic carbon (SOC), N, and P stocks were measured in Huanxian County of the wider Loess Plateau, representing five major land use categories. Sites were sampled three times over 3 yr. In all, almost 2 800 soil analyses were performed. A feature of these soils is low SOC content in the A horizon but comparatively small decline with soil depth. For example, SOC levels for the 0-20 cm and 70-100 cmsoil depths averaged 6.1 and 4.1Mg ha-1, respectively. Alfalfa and rangeland sites had 5.1 Mg ha-1 (10%) more total than cropland and 7.5 t ha-1 (16%) more total SOC to 100-cm soil depth than the two silvopastoral sites. For total soil N (0- to 100-cm soil depth) the averages of alfalfa and RL siteswere 20% and 28%, respectively, higher than the cropland and silvopastoral site group means, although soil C, N, and P levels are very low, relative to those of typical soils elsewhere. When these observations are scaled up to a regional level, it can be calculated that a 5% shift in land use from cropping or silvopastoral systems to alfalfa-based systems could increase soil C sequestration by as many as 20 million t CO2 per yr, although some caution is needed in making extrapolations, as the present data are from a single locality on the Loess Plateau.