Browsing by Author "Imran M"

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    Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage
    (MDPI (Basel, Switzerland), 2019-11) Imran M; Saleemi MK; Chen Z; Wang X; Zhou D; Li Y; Zhao Z; Zheng B; Li Q; Cao S; Ye J
    Flaviviruses, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), Dengue virus (DENV), and West Nile virus (WNV), are important arthropod-borne pathogens that present an immense global health problem. Their unpredictable disease severity, unusual clinical features, and severe neurological manifestations underscore an urgent need for antiviral interventions. Furin, a host proprotein convertase, is a key contender in processing flavivirus prM protein to M protein, turning the inert virus to an infectious particle. For this reason, the current study was planned to evaluate the antiviral activity of decanoyl-Arg-Val-Lys-Arg-chloromethylketone, a specific furin inhibitor, against flaviviruses, including ZIKV and JEV. Analysis of viral proteins revealed a significant increase in the prM/E index of ZIKV or JEV in dec-RVKR-cmk-treated Vero cells compared to DMSO-treated control cells, indicating dec-RVKR-cmk inhibits prM cleavage. Plaque assay, qRT-PCR, and immunofluorescence assay revealed a strong antiviral activity of dec-RVKR-cmk against ZIKV and JEV in terms of the reduction in virus progeny titer and in viral RNA and protein production in both mammalian cells and mosquito cells. Time-of-drug addition assay revealed that the maximum reduction of virus titer was observed in post-infection treatment. Furthermore, our results showed that dec-RVKR-cmk exerts its inhibitory action on the virus release and next round infectivity but not on viral RNA replication. Taken together, our study highlights an interesting antiviral activity of dec-RVKR-cmk against flaviviruses.
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    New Zealand public transport agencies' responses to COVID-19: Understanding public transport services, infrastructure and communication measures
    (John Wiley and Sons, Inc., 2024-05-01) Whale J; Imran M
    COVID-19 brought public health challenges to the public transport system throughout the world. As a result, a range of response measures were implemented to ensure the safety of passengers while maintaining a functioning system. This paper explores the responses of public transport agencies in New Zealand's metropolitan cities (Auckland, Christchurch and Wellington) to the COVID-19 pandemic by examining their physical and communication measures. We analysed public transport agencies' websites to understand the response measures implemented, including the accessibility of COVID-19-related information, and the communication of information via websites and social media platforms. The results show that 13 service responses were implemented across the three public transport agencies, with Auckland implementing the most measures. Seven infrastructural responses were implemented, with Christchurch implementing all seven. Wellington was found to be the public transport agency that used social media the most during the pandemic. The website accessibility findings suggest that the more accessible a public transport agency's website was, the less information was present. The research concludes that all three public transport agencies in New Zealand performed reasonably well and were able to maintain a safe and responsive public transport system.
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    Transitioning towards a circular economy solar energy system in Northern Australia: insights from a multi-level perspective
    (Taylor and Francis Group, 2023-05-04) Mathur D; Gregory R; Imran M
    Increasing resource efficiency and decreasing waste by 2030 through prevention, reduction, recycling and reuse is one of the 17 United Nations Sustainable Development Goals. Australia is predicted to have up to 145,000 t of solar panel waste by 2030 and many large-scale solar systems are proposed to be built across Northern Australia. Research suggests that solar panel consumption and waste patterns are not dissimilar to other forms of e-waste such as mobile phones. Consequently, there is a need to rethink how the end of life of solar panels is managed. In this paper we raise the question of how Northern Australia should plan for managing solar panel waste arising from these huge installations in the future. This paper draws on the multi-level perspective, as a framework for conceptualising the transition challenges associated with promoting a circular solar energy system in the region. Adopting this approach facilitates consideration of social, technical and political drivers of solar panel waste and their implications for governance and planning in regional Australia. It is suggested that planning activities aimed at strategic, tactical and operational levels can help Northern Australia transition into a sustainable regional future. Practitioner pointers: Need to develop planning system/framework/process for waste arising from solar farms. Usefulness of the multi-level perspective for identifying the range of stakeholders, barriers and drivers. Rethinking regional development of Northern Australia through a new industry space between the solar and waste sectors.