Browsing by Author "Koopmans MPG"

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Mpox: A case study for a one health approach to infectious disease prevention
(Elsevier B V, Amsterdam, 2025-06) Hayman DTS; Koopmans MPG; Cunningham AA; Bukachi SA; Masirika LM; Markotter W; Mettenleiter TC
Mpox has been declared a global health emergency twice by the World Health Organization due to its impacts within and beyond Africa. Enzootic in Central and West African wildlife, mpox outbreaks have resulted from zoonotic spillover, with recent events revealing increased human-to-human transmission. Factors like population growth and environmental disruption, alongside reduced smallpox immunity, increase emergence risk. In addition, the emergence in South Kivu of a distinct subclade of mpox virus points at a currently understudied aspect of mpox virus lineages and their dynamics in reservoir hosts. A One Health approach—integrating human, animal, and environmental science—is essential for reducing the risk of mpox emergence. This approach should encompass ecological studies to understand putative reservoir population dynamics and the potential for interventions, reducing activities that increase human-animal contacts, respectful community engagement to reduce spillover risk from cultural practices (such as hunting multiple species of wildlife for consumption), and socially acceptable and equitable access to medical and non-medical countermeasures to prevent or control ongoing human-to-human transmission. Politically supported collaborative efforts across disciplines with involvement of stakeholders are critical to promote and strengthen socially and environmentally sustainable practices to mitigate future outbreaks.
One Health: A new definition for a sustainable and healthy future
(PLOS, 2022-06-23) One Health High-Level Expert Panel (OHHLEP); Adisasmito WB; Almuhairi S; Behravesh CB; Bilivogui P; Bukachi SA; Casas N; Cediel Becerra N; Charron DF; Chaudhary A; Ciacci Zanella JR; Cunningham AA; Dar O; Debnath N; Dungu B; Farag E; Gao GF; Hayman DTS; Khaitsa M; Koopmans MPG; Machalaba C; Mackenzie JS; Markotter W; Mettenleiter TC; Morand S; Smolenskiy V; Zhou L; Dvorin JD
Prevention of zoonotic spillover: From relying on response to reducing the risk at source.
(Public Library of Science (PLoS), 2023-10-05) Authored by the members of the One Health High-Level Expert Panel (OHHLEP); Markotter W; Mettenleiter TC; Adisasmito WB; Almuhairi S; Barton Behravesh C; Bilivogui P; Bukachi SA; Casas N; Cediel Becerra N; Charron DF; Chaudhary A; Ciacci Zanella JR; Cunningham AA; Dar O; Debnath N; Dungu B; Farag E; Gao GF; Hayman DTS; Khaitsa M; Koopmans MPG; Machalaba C; Mackenzie JS; Morand S; Smolenskiy V; Zhou L; Dvorin JD
The devastating impact of Coronavirus Disease 2019 (COVID-19) on human health globally has prompted extensive discussions on how to better prepare for and safeguard against the next pandemic. Zoonotic spillover of pathogens from animals to humans is recognized as the predominant cause of emerging infectious diseases and as the primary cause of recent pandemics [1]. This spillover risk is increased by a range of factors (called drivers) that impact the nature, frequency, and intensity of contact between humans and wild animals. Many of these drivers are related to human impact, for example, deforestation and changes in land use and agricultural practices. While it is clear that the triad of prevention-preparedness-response (P-P-R) is highly relevant, there is much discussion on which of these 3 strategic activities in the field of emerging infectious disease should be prioritized and how to optimally target resources. For this, it is important to understand the scope of the respective activity and the consequences of prioritization.