Browsing by Author "Lee S"

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Comorbidity and temporal associations between mental disorders among college students in the world mental health international college student initiative
(Elsevier B V, 2025-09-01) Roest AM; de Vries YA; Pozuelo JR; Petukhova MV; Lee S; Sampson NA; Albor Y; Alhadi AN; Alonso J; Al-Saud N; Altwaijri Y; Andersson C; Atwoli L; Auerbach RP; Muaka CA; Báez-Mansur PM; Ballester L; Bantjes J; Baumeister H; Bendtsen M; Benjet C; Berman AH; Bruffaerts R; Carrasco P; Chan SCN; Cohut I; Couder MAC; Crockett MA; Cuijpers P; David OA; Dong D; Ebert DD; Gaete J; Forero CG; Gili M; Gutiérrez-García R; Haro JM; Hasking P; Hunt X; Husky MM; Jaguga F; Langer ÁI; Léniz I; Liu Y; Mac-Ginty S; Martínez V; McLafferty M; Miranda A; Monroy-Velasco IR; Murray EK; Musyoka CM; Nedelcea C; Núñez D; O'Neill SM; Piqueras JA; Popescu CA; Prescivalli AP; Rapsey C; Robinson K; Rodriguez-Jimenez T; Saal W; Siu O-L; Stein DJ; Struijs SY; Tomoiaga CT; Valdés-García KP; Vargas-Contreras E; Vigo DV; Wang AY; Wong SYS; Kessler RC; World Mental Health International College Student collaborators
Background: Mental disorders are highly prevalent among students worldwide. This study aims to examine comorbidity and temporal associations between mental disorders among students. Methods: The study included 72,288 students from 18 countries as part of the World Mental Health International College Student (WMH-ICS) Initiative, with cross-sectional data collected between 2017 and 2023. Screening for common DSM-5 disorders was conducted using validated screening measures. Latent variables were examined using exploratory principal axis factor analysis on a correlation matrix among the lifetime mental disorders. Based on age-of-onset information, multivariable poisson regression models were used to examine associations of prior disorders with the first onset of other disorders. Results: 27.0 % of students screened positive for only one lifetime disorder, 17.1 % for two, 10.9 % for three, and 10.6 % for 4+ disorders. In the factor analysis, three latent variables were found, comprising: internalizing disorders (generalized anxiety disorder, major depressive episode, post-traumatic stress disorder, and panic disorder), substance use disorders (drug use disorder and alcohol use disorder), and externalizing disorders (attention deficit/hyperactivity disorder and mania/hypomania). Prior internalizing and externalizing disorders were associated with the subsequent first onset of all other disorders with risk ratios ranging from 1.5–7.5. Substance use disorders were less consistently associated with the subsequent first onset of other disorders, but alcohol use disorder was associated with the first onset of drug use disorder and vice versa. Conclusions: Mental disorder comorbidity is common among students, and students with disorders across the internalizing and externalizing spectrum have an increased risk of future mental disorder comorbidities.
The associations of childhood adversities and mental disorders with suicidal thoughts and behaviors - Results from the World Mental Health International College Student Initiative
(Elsevier B V, 2025-08-01) Mortier P; Yang X; Altwaijri YA; Holdcraft JA; Lee S; Sampson NA; Albor Y; Alhadi AN; Alonso J; Al-Saud NK; Andersson C; Atwoli L; Auerbach RP; Muaka CA; Báez-Mansur PM; Ballester L; Bantjes J; Baumeister H; Bendtsen M; Benjet C; Berman AH; Bruffaerts R; Carrasco P; Chan SCN; Cohut I; Covarrubias Díaz Couder MA; Crockett MA; Cuijpers P; David OA; Dong D; Ebert DD; Gaete J; Felez-Nobrega M; García Forero C; Gili M; Gutiérrez-García RA; Haro JM; Hasking P; Hunt X; Husky MM; Jaguga F; Jansen L; Langer ÁI; Liu Y; Mac-Ginty S; Martínez V; Mason A; Mathai M; McLafferty M; Miranda-Mendizabal A; Murray EK; Musyoka CM; O'Neill SM; Papasteri CC; Piqueras JA; Popescu CA; Rapsey C; Robinson K; Rodriguez-Jimenez T; Scarf D; Siu O-L; Stein DJ; Struijs SY; Tomoiaga CT; Valdés-García KP; Vereecke S; Vigo DV; Wang AY; Wong SYS; Kessler RC; World Mental Health International College Student collaborators
Objective: To investigate the associations of demographic variables, childhood adversities (CAs), and mental disorders (MDx) with onset, transition, and persistence of suicidal thoughts and behaviors (STB) among first-year university students. Method: Poisson regression models within a discrete-time survival framework were constructed using web-based self-report survey data from 72,288 incoming university students across 18 countries (response rate=20.9%; median age=19 years, 57.9% female, 1.4% transgender, 21.0% non-heterosexual). These models examined the associations of four demographic variables, five CAs, and eight MDx with STB outcomes. Results: Lifetime prevalence of suicidal ideation, plans, and attempts was 47.0%, 26.0%, and 9.6%, respectively; 12-month estimates were 30.6%, 14.0%, and 2.3%. In unadjusted analyses, associations were strongest between lifetime onset of suicidal ideation and CAs (RR range 4.4–7.0), particularly parental psychopathology (relative risk [RR]=7.0 [95% CI 6.5–7.7]), followed by MDx (RR range 1.3–3.0). Of the demographic subgroups, transgender students had highest risk of STB (lifetime ideation onset RR=2.4 [2.3–2.6]; ideation-to-attempt transition RR=1.5 [1.3–1.8]). In fully adjusted models, strongest predictors of lifetime ideation onset were emotional abuse (RR=2.1 [1.9–2.2]), major depressive disorder (RR=2.0 [1.9–2.1]), and bipolar disorder (RR=1.8 [1.6–2.0]). Ideation-to-attempt transition remained most strongly associated with panic disorder (RR=1.5 [1.3–1.7]), bipolar disorder (RR=1.4 [1.2–1.7]), and sexual abuse (RR=1.4 [1.2–1.7]). Most predictors were significantly but weakly associated with persistence of ideation and plan, while only physical abuse remained associated with repeated suicide attempts (RR=1.3 [1.0–1.8]). Conclusion: CAs and MDx are strong predictors of both onset of and transition within the STB spectrum, underscoring the importance of implementing early-life prevention interventions.
The relationships between sporadic and repetitive non-suicidal self-injury and mental disorders among first-year college students: results from the World Mental Health International College Student Initiative
(Cambridge University Press, 2025-09-25) Hasking P; Kiekens G; Petukhova MV; Albor Y; Al-Hadi A; Alonso J; Al-Saud N; Altwaijri Y; Andersson C; Atwoli L; Muaka CA; Báez-Mansur P; Ballester L; Bantjes J; Baumeister H; Bendtsen M; Benjet C; Berman A; Bruffaerts R; Carrasco P; Chan S; Cohut I; Couder MCD; Cristóbal-Narvaez P; Cuijpers P; David O; Dong D; Ebert D; Gaete J; Forero CG; Gutiérrez-García R; Haro J; Hunt X; Hurks P; Husky M; Jaguga F; Jansen L; Jiménez-Pérez A; Kählke F; Klinkenberg E; Langer Á; Lee S; Lima RA; Liu Y; Lochner C; Mac-Ginty S; Martínez V; Mason A; McLafferty M; Mori T; Murray E; Musyoka C; Nedelcea C; Núñez D; O’Neill S; Piqueras J; Popescu C; Rapsey C; Robinson K; Roca M; Rodriguez-Jimenez T; Salemink E; Sampson N; Scarf D; Siu O-L; Stein D; Struijs SY; Tomoiaga C; Valdés-García K; van der Heijde C; Vigo D; Voorspoels W; Wang A; Wong S; Nock M; Kessler R; World Mental Health - International College Student collaborators
Background. Non-suicidal self-injury (NSSI) is associated with mental disorders, yet work regarding the direction of this association is inconsistent. We examined the prevalence, comorbidity, time–order associations with mental disorders, and sex differences in sporadic and repetitive NSSI among emerging adults. Methods. We used survey data from n = 72,288 first-year college students as part of the World Mental Health-International College Student Survey Initiative (WMH-ICS) to explore time–order associations between onset of NSSI and mental disorders, based on retrospective age-of-onset reports using discrete-time survival models. We distinguished between sporadic (1–5 lifetime episodes) and repetitive (≥6 lifetime episodes) NSSI in relation to DSM-5 mood, anxiety, and externalizing disorders. Results. We estimated a lifetime NSSI rate of 24.5%, with approximately half reporting sporadic NSSI and half repetitive NSSI. The time–order associations between onset of NSSI and mental disorders were bidirectional, but mental disorders were stronger predictors of the onset of NSSI (median RR = 1.94) than vice versa (median RR = 1.58). These associations were stronger among individuals engaging in repetitive rather than sporadic NSSI. While associations between NSSI and mental disorders generally did not differ by sex, repetitive NSSI was a stronger predictor for the onset of subsequent substance use disorders among females compared to males. Most mental disorders marginally increased the risk for persistent repetitive NSSI (median RR = 1.23). Conclusions. Our findings offer unique insights into the temporal order between NSSI and mental disorders. Further work exploring the mechanism underlying these associations will pave the way for early identification and intervention of both NSSI and mental disorders.
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV.
(AMER PHYSICAL SOC, 9/07/2010) Khachatryan V; Sirunyan AM; Tumasyan A; Adam W; Bergauer T; Dragicevic M; Erö J; Fabjan C; Friedl M; Frühwirth R; Ghete VM; Hammer J; Hänsel S; Hoch M; Hörmann N; Hrubec J; Jeitler M; Kasieczka G; Kiesenhofer W; Krammer M; Liko D; Mikulec I; Pernicka M; Rohringer H; Schöfbeck R; Strauss J; Taurok A; Teischinger F; Waltenberger W; Walzel G; Widl E; Wulz C-E; Mossolov V; Shumeiko N; Suarez Gonzalez J; Benucci L; Ceard L; De Wolf EA; Hashemi M; Janssen X; Maes T; Mucibello L; Ochesanu S; Roland B; Rougny R; Selvaggi M; Van Haevermaet H; Van Mechelen P; Van Remortel N; Adler V; Beauceron S; Blyweert S; D'Hondt J; Devroede O; Kalogeropoulos A; Maes J; Maes M; Tavernier S; Van Doninck W; Van Mulders P; Villella I; Chabert EC; Charaf O; Clerbaux B; De Lentdecker G; Dero V; Gay APR; Hammad GH; Marage PE; Vander Velde C; Vanlaer P; Wickens J; Costantini S; Grunewald M; Klein B; Marinov A; Ryckbosch D; Thyssen F; Tytgat M; Vanelderen L; Verwilligen P; Walsh S; Zaganidis N; 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Lelas D; Lelas K; Plestina R; Polic D; Puljak I; Antunovic Z; Dzelalija M; Brigljevic V; Duric S; Kadija K; Morovic S; Attikis A; Fereos R; Galanti M; Mousa J; Nicolaou C; Papadakis A; Ptochos F; Razis PA; Rykaczewski H; Tsiakkouri D; Zinonos Z; Mahmoud M; Hektor A; Kadastik M; Kannike K; Müntel M; Raidal M; Rebane L; Azzolini V; Eerola P; Czellar S; Härkönen J; Heikkinen A; Karimäki V; Kinnunen R; Klem J; Kortelainen MJ; Lampén T; Lassila-Perini K; Lehti S; Lindén T; Luukka P; Mäenpää T; Tuominen E; Tuominiemi J; Tuovinen E; Ungaro D; Wendland L; Banzuzi K; Korpela A; Tuuva T; Sillou D; Besancon M; Dejardin M; Denegri D; Descamps J; Fabbro B; Faure JL; Ferri F; Ganjour S; Gentit FX; Givernaud A; Gras P; Hamel de Monchenault G; Jarry P; Locci E; Malcles J; Marionneau M; Millischer L; Rander J; Rosowsky A; Rousseau D; Titov M; Verrecchia P; Baffioni S; Bianchini L; Bluj M; Broutin C; Busson P; Charlot C; Dobrzynski L; Elgammal S; Granier de Cassagnac R; Haguenauer M; Kalinowski A; Miné P; 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Albergo S; Cappello G; Chiorboli M; Costa S; Tricomi A; Tuve C; Barbagli G; Broccolo G; Ciulli V; Civinini C; D'Alessandro R; Focardi E; Frosali S; Gallo E; Genta C; Lenzi P; Meschini M; Paoletti S; Sguazzoni G; Tropiano A; Benussi L; Bianco S; Colafranceschi S; Fabbri F; Piccolo D; Fabbricatore P; Musenich R; Benaglia A; Cerati GB; De Guio F; Di Matteo L; Ghezzi A; Govoni P; Malberti M; Malvezzi S; Martelli A; Massironi A; Menasce D; Miccio V; Moroni L; Negri P; Paganoni M; Pedrini D; Ragazzi S; Redaelli N; Sala S; Salerno R; Tabarelli de Fatis T; Tancini V; Taroni S; Buontempo S; Cimmino A; De Cosa A; De Gruttola M; Fabozzi F; Iorio AOM; Lista L; Noli P; Paolucci P; Azzi P; Bacchetta N; Bellan P; Bellato M; Biasotto M; Bisello D; Carlin R; Checchia P; De Mattia M; Dorigo T; Fanzago F; Gasparini F; Giubilato P; Gresele A; Lacaprara S; Lazzizzera I; Margoni M; Maron G; Meneguzzo AT; Nespolo M; Perrozzi L; Pozzobon N; Ronchese P; Simonetto F; Torassa E; Tosi M; Triossi A; Vanini S; Zumerle G; 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CMS Collaboration
Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at square root of s = 7 TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN(ch)/dη|(|η|<0.5) = 5.78 ± 0.01(stat) ± 0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from square root of s = 0.9 to 7 TeV is [66.1 ± 1.0(stat) ± 4.2(syst)]%. The mean transverse momentum is measured to be 0.545 ± 0.005(stat) ± 0.015(syst) GeV/c. The results are compared with similar measurements at lower energies.