Browsing by Author "Shaddel R"

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    Nanodelivery systems of thymoquinone for improving its bioavailability and efficiency in the food and biomedical applications
    (Elsevier B V, 2025-10-15) Shaddel R; Rashidinejad A; Karimkhani MM; Tarhan O; Jafari SM
    Thymoquinone (TQ), a hydrophobic bioactive constituent of Nigella sativa seeds, has garnered attention for its potential in treating various ailments due to its antioxidative and anti-inflammatory properties. However, TQ's hydrophobicity, instability in varying pH environments, photosensitivity, rapid hepatic metabolism, and low bioavailability present major challenges for its application in pharmaceutical and nutraceutical formulations. Nanotechnology offers innovative nanocarriers that can overcome these limitations. Notable among these are lipid-based nanocarriers (e.g., nano-liposomes, nano-emulsions, niosomes, solid lipid nanoparticles, and nanostructured lipid carriers), biopolymeric systems (e.g., nano-hydrogels, nanofibers, nanotubes, and cyclodextrin inclusion complexes), and inorganic nanocarriers. These delivery systems are designed to enhance TQ's solubility, protect it from degradation, and improve its bioavailability and therapeutic performance. Despite numerous advances, the clinical and industrial translation of these nano-delivery systems remains limited, primarily due to scalability issues, regulatory constraints, and a lack of standardized evaluation protocols for food and biomedical use. This review provides a comprehensive analysis of these nanocarriers, emphasizing their mechanisms for TQ encapsulation, controlled release, and bioaccessibility enhancement. It also highlights current limitations and outlines future directions for their development. Unlike previous reviews, this work offers a comparative evaluation of nanocarrier systems for both food and biomedical applications, addressing their effectiveness, limitations, and readiness for real-world translation. The key takeaway is that among the various approaches, lipid-based and biopolymeric nanocarriers have demonstrated the greatest potential for enhancing TQ delivery, particularly in oral and functional food formulations, as well as targeted cancer therapy, due to their biocompatibility, scalability, and effective release profiles.
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    The direct and indirect effects of bioactive compounds against coronavirus
    (John Wiley and Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University, 2022-03-16) Tomas M; Capanoglu E; Bahrami A; Hosseini H; Akbari-Alavijeh S; Shaddel R; Rehman A; Rezaei A; Rashidinejad A; Garavand F; Goudarzi M; Jafari SM
    Emerging viruses are known to pose a threat to humans in the world. COVID-19, a newly emerging viral respiratory disease, can spread quickly from people to people via respiratory droplets, cough, sneeze, or exhale. Up to now, there are no specific therapies found for the treatment of COVID-19. In this sense, the rising demand for effective antiviral drugs is stressed. The main goal of the present study is to cover the current literature about bioactive compounds (e.g., polyphenols, glucosinolates, carotenoids, minerals, vitamins, oligosaccharides, bioactive peptides, essential oils, and probiotics) with potential efficiency against COVID-19, showing antiviral activities via the inhibition of coronavirus entry into the host cell, coronavirus enzymes, as well as the virus replication in human cells. In turn, these compounds can boost the immune system, helping fight against COVID-19. Overall, it can be concluded that bioactives and the functional foods containing these compounds can be natural alternatives for boosting the immune system and defeating coronavirus.