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1995 - 19972

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    The effect of oestradiol-17β (Compudose ®) on liveweight gain, herbage intake and circulating hormone concentrations in steers at pasture : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Animal Science at Massey University, New Zealand
    (Massey University, 1995) Osorio, Gilberto Aranda
    World food production needs to increase as world population is increasing. One method of achieving this is to improve the efficiency of food production. Efficient meat production in steers is affected by growth rate, mature weight and composition of the growth. It is possible manipulate growth rate by the administration of sex steroids. Compudose® (oestradiol-17β) improves liveweight gain (14-17%) and feed conversion efficiency (10-12%) in beef cattle under feedlot and grazing conditions. There is little information available on feed intake and hence efficiency of liveweight gain under New Zealand pastoral systems. Therefore, this study was designed to evaluate over a 203 day period the effect of Compudose® on liveweight gain, herbage intake, grazing behaviour and circulating hormone and metabolite concentrations in steers grazing ryegrass-white clover pastures. Twenty 14-month-old Friesian steers and sixteen 14-month-old Angus cross were randomly assigned within breed to either Compudose® or no-Compudose®. Herbage intake and grazing behaviour were measured on two occasions (days 34-50 and days 168-184). Blood samples from the steers were taken at 50-day intervals throughout the trial. Compudose® steers gained a mean of 856 g/d compared with 710 g/d by control steers (P<0.001). The total fasted and unfasted LWG of treated steers was improved by 29.6 kg (20.5%) or 36.3 kg (25%), respectively, over the untreated steers. There were no significant (P>0.05) differences in the amount of herbage eaten between treated and untreated groups (7.4 vs 7.1 kg DM/hd/day). Feed conversion efficiency in the implanted group was improved by 15.7% over the untreated steers. Grazingbehaviour, hormone and metabolite concentrations between treated and untreated steers were not significantly different (P>0.05). The use of Compudose® resulted in a net income of $55 per implanted steer. In conclusion Compudose® implants proved to be a useful management tool to increase performance and productivity in finishing steers under New Zealand pasture-based systems.
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    Compudose, its effects on Hereford X Friesian heifers : a thesis presented in partial fulfilment of the requirement for the degree of Master of Applied Science (in Animal Science) at Massey University
    (Massey University, 1997) Burke, Jennifer L
    Compudose is an oestrogenic growth promotant that improves liveweight gain and feed conversion efficiency in steers. In the past it has not been recommended for use in breeding heifers because of the adverse effects of oestrogen treatment on reproductive performance. The effects of Compudose on liveweight gain, skeletal development, lactational performance, carcass characteristics and offspring performance in heifers at pasture are unknown. However, the expected increase in liveweight gain from Compudose treatment may allow target growth rates to be attained in heifers at critical times of the year, without lactational performance being affected. This study investigated the effect of treating Hereford x Friesian (H x F) once-bred heifers (OBH) with Compudose 400 at 3 months (90 days) of age (Compudose 90) and 7 months (210 days) of age (Compudose 210) compared to non-treated heifers (Control). Compudose 90 heifers (n = 14) gained 0.63 kg/day compared with Control heifers (n = 17) which gained 0.59 kg/day for 385 days from the time of implantation (6.8% increase, P < 0.05). Subsequently Compudose 90 heifers achieved greater liveweights than Control (P > 0.05) and Compudose 210 (n = 17) heifers (P < 0.05) at pre-mating (by 17.7 kg and 16.9 kg, respectively), pre-calving (by 13.7 kg and 25.3 kg, respectively), weaning (by 13.9 kg and 32.8 kg, respectively) and slaughter (by 23.1 kg and 39.9 kg, respectively). Liveweight gain between Control and Compudose 210 heifers did not differ over the 383 day period of implantation. Carcasses of Compudose 90 heifers were 10.5 kg heavier than carcasses of Control (P > 0.0.5) and 19.2 kg heavier than carcasses of Compudose 210 heifers (P < 0.05). Wither height, girth, hip height, hip width, pelvic height and pelvic area did not differ significantly between treatment groups, but pelvic width of Compudose-treated heifers was significantly smaller than that of Control heifers (P < 0.01). Compudose 90 and Compudose 210 heifers had an average calving date 8 days (P < 0.10) and 10 days (P < 0.05), respectively, later than the average calving date of Control heifers, and more compact calving spreads. There were no treatment differences in calf birthweight, however calves born to Control heifers were 15.3 kg and 16.2 kg heavier at weaning than calves born to Compudose 90 and Compudose 210 heifers (P < 0.05). Compudose treatment and associated higher growth rates did not affect milk yield, as determined by the weight-nurse-weigh (WNW) method, at 4 and 8 weeks of lactation; udder volder volume at 4 weeks, 8 weeks and 12 weeks of lactation (weaning), and at pre-slaughter; or udder weight at slaughter. There were no significant differences in carcass quality characteristics between treatment groups. However, carcasses of Compudose-treated heifers tended to be shorter (P < 0.10) and have a greater rib-eye area. No significant differences in fat content, as determined by the weight of kidney and pelvic fat and fat depth, were detected between treatment groups. Implanting heifers with Compudose at 3 months of age is more beneficial than implanting heifers with Compudose at 7 months of age, but the small liveweight gain advantage would not be economically advantageous. It is concluded that Compudose is not a practical solution for improving the rearing of beef or dairy heifers, despite lactational performance not being affected.