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    Pharmacokinetics and effect on renal function and average daily gain in lambs after castration and tail docking, of firocoxib and meloxicam.
    (Taylor and Francis Group, 2023-07-16) Kongara K; Purchas G; Dukkipati V; Venkatachalam D; Ward N; Hunt H; Speed D
    AIMS: To evaluate and compare the pharmacokinetics of IM and oral firocoxib, and IM meloxicam, and detect their effect on renal function and average daily gain (ADG) in lambs undergoing tail docking and castration. METHODS: Seventy-five male Romney lambs, aged 3-6 weeks, were randomised into five treatment groups (n = 15 per group): IM firocoxib (1 mg/kg); oral firocoxib (1 mg/kg); IM meloxicam (1 mg/kg); normal saline (approximately 2 mL, oral); or sham. Following the treatment administration, hot-iron tail docking and rubber ring castration were performed in all groups except the sham group, which did not undergo the procedures, but the animals were handled in the same manner as castrated and tail docked lambs. Blood samples were collected before and 1, 2, 4, 6, 8, 24, 48, 72, 96 and 120 hours after treatment administration, and drug concentrations in plasma were quantified by liquid chromatography and mass spectrometry. Plasma urea and creatinine concentrations were determined at a commercial laboratory. Lamb body weights were recorded before and 2, 4 and 8 weeks after tail docking and castration. The pharmacokinetic analysis was carried out using a non-compartmental approach. Between-group and between-time-point differences were compared using mixed model analyses. RESULTS: There was no evidence for a difference in plasma elimination half-life between firocoxib given IM (LSM 18.6 (SE 1.4) hours), firocoxib given orally (LSM 18.2 (SE 1.4) hours), and meloxicam given IM (LSM 17. 0 (SE 1.4) hours). Firocoxib (IM) had a significantly greater volume of distribution (LSM 3.7 (SE 0.2) L/kg) than IM meloxicam (LSM 0.2 (SE 0.2) L/kg). Lambs in the meloxicam group had higher (p < 0.05) plasma urea and creatinine concentrations than those in the firocoxib, saline and sham groups. Lambs' ADG was decreased (p < 0.01) compared to the other treatment groups in the 0-2 week period following meloxicam administration. CONCLUSIONS AND CLINICAL RELEVANCE: Both formulations of firocoxib had a long plasma elimination half-life and large volume of distribution. There was a transient reduction in ADG in the meloxicam group, possibly due to mild renal toxicity. Comparative studies on dose-response effects of firocoxib and meloxicam in lambs following the procedures are required.
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    Variability in growth rates of goat kids on 16 New Zealand dairy goat farms
    (New Zealand Society of Animal Production, 7/07/2016) Deeming LE; Beausoleil NJ; Stafford KJ; Webster JR; Zobel G
    Average daily weight gains (ADG) in early life are associated with health, welfare and future production potential of dairy animals. While this has yet to be established for goats, research in cows demonstrates a positive relationship between growth in early life and milk production (Shamay et al. 2005, Soberon et al. 2012). Early growth rates are largely determined by the management practices from birth onwards. It is therefore unsurprising that large differences in ADG under different management systems have been reported. In lambs, Mahgoub et al. (2000) reported a large range in ADG (84-154 g/day). Similarly, in calves, Bartlett et al. (2006) reported ADGs ranging from 251 g/day to 703 g/day. The ADGs reported in goats have not been as variable (152-170 g/day: Galina et al. 1995; 167-173 g/day: Goetsch et al. 2001); however, these were small, controlled studies. To our knowledge, no research has yet quantified variability in the ADG of goat kids on a large, multi-farm scale. Therefore, the aim of this study was to describe the variation in growth rates on multiple dairy goat farms in the Waikato region of NZ, providing a benchmark for dairy goat farmers.