Concentration of 12 Oligosaccharides in the Milk of New Zealand Breastfeeding Women

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dc.citation.issue18
dc.citation.volume1
dc.contributor.authorJia LL
dc.contributor.authorBrough L
dc.contributor.authorWeber JL
dc.contributor.editorSmith C
dc.contributor.editorMackay S
dc.contributor.editorJalili-Moghaddam S
dc.contributor.editorGibbs M
dc.coverage.spatialWellington, New Zealand
dc.date.accessioned2025-07-18T02:44:36Z
dc.date.available2025-07-18T02:44:36Z
dc.date.finish-date2022-12-02
dc.date.issued2023-03-23
dc.date.start-date2022-12-01
dc.description.abstractHuman milk oligosaccharides (HMOs) are the third most abundant component in breast milk. HMOs benefit infant gut health, modulate immune responses, and promote brain development. The profile and concentration of HMOs vary considerably among breastfeeding women, and are reported to be associated with genetic, maternal, and environmental factors as well as feeding practices. One reason for the diversity in HMO concentration is the secretor gene, which determines the presence of an enzyme responsible for the synthesis of 2′-FL and LNFP-I. To date, there is no report about HMO concentration or profile in the New Zealand population. Our objective was to investigate 12 HMO concentrations in a small sample of New Zealand women. Sixty-eight breastfeeding mothers (mean age 32 years, 77% Caucasian) of singleton infants (median age [Q1, Q3] 108 [70, 166] days) were included, with 65% exclusively breastfeeding and 54% who had two or more children. Concentrations of 12 HMOs were measured by UHPLC with fluorescence detection. Overall, 68% of mothers were secretors, which was defined by the presence of 2′-FL in the milk. HMO profiles varied widely; total HMO concentration varied 4.2-fold between women; and individual HMOs varied from 4.8-fold to >100-fold. The median of total HMO concentration (Q1, Q3) of the secretors and non-secretors were 6774.9 (6395.4, 8245.6) mg/L and 7128.0 (6093.1, 7880.1) mg/L respectively. Significant differences in concentration of 2′-FL, 3-FL, A-Tet, LNFP-I, LNFP-II, LNFPV, and LNnT between secretors and non-secretors were found by Mann–Whitney tests. However, there was no significant difference in concentrations of LNFP-III, LNnFP, 3′-SL, 6′-SL, LNT, or total HMOs between the secretors and the non-secretors. HMO concentrations vary broadly between breastfeeding women. A longitudinal cohort of a larger sample size is required to fully investigate HMO profiles at different lactation stages of New Zealand women and to further explore the influence of maternal and environmental factors on HMO concentration.
dc.description.confidentialfalse
dc.description.place-of-publicationBasel, Switzerland
dc.format.pagination26-26
dc.identifier.citationJia LL, Brough L, Weber JL. 2022-12-01 to 2022-12-02. Concentration of 12 Oligosaccharides in the Milk of New Zealand Breastfeeding Women. Annual Scientific Meeting of the Nutrition Society of New Zealand 2022. Wellington, New Zealand.
dc.identifier.doi10.3390/msf2023018026
dc.identifier.eissn2673-9992
dc.identifier.elements-typec-conference-abstract
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/73211
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2673-9992/18/1/26
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source.journalMedical Sciences Forum
dc.source.name-of-conferenceAnnual Scientific Meeting of the Nutrition Society of New Zealand 2022
dc.subjecthuman milk oligosaccharides
dc.subjectbreastfeeding
dc.subjecthuman lactation
dc.titleConcentration of 12 Oligosaccharides in the Milk of New Zealand Breastfeeding Women
dc.typeconference
pubs.elements-id480459
pubs.organisational-groupOther
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