Browsing by Author "Garg ML"
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- ItemBioactive Yoghurt Containing Curcumin and Chlorogenic Acid Reduces Inflammation in Postmenopausal Women(MDPI (Basel, Switzerland), 2022-11-02) Ahmed Nasef N; Thota RN; Mutukumira AN; Rutherfurd-Markwick K; Dickens M; Gopal P; Singh H; Garg ML; Bordoni AMenopause is marked by a gradual and permanent decrease of estrogen from the ovaries, leading to metabolic and physiological changes in the body. Combined with increased body mass index, postmenopausal women have elevated systemic inflammation and metabolic disturbances leading to increased risk of developing chronic diseases. A bioactive coconut yoghurt containing curcumin and chlorogenic acid was developed with the potential to target inflammatory processes. In this randomized crossover study, healthy postmenopausal women with a BMI of 25-40 were recruited to consume 125 g of either the bioactive or placebo yoghurt. Blood samples were collected at baseline, 30 min, and 1, 2, 3 and 4 h postprandially. Plasma inflammatory markers (TNFα and IL6) and metabolic markers (triglycerides, insulin and glucose) were measured. Participants had significantly lower plasma TNFα Cmax after consumption of the bioactive yoghurt compared to placebo (mean difference = 0.3 pg/mL; p = 0.04). Additionally, plasma TNFα was significantly lower postprandially compared to baseline after consumption of the bioactive yogurt but not the placebo. No differences were observed in the metabolic markers measured. Conclusions: The bioactive yoghurt fortified with curcumin and chlorogenic acid has the potential to reduce inflammatory mediators; however, a larger and longer-term study is required to confirm these findings.
- ItemDifferential effects of saturated and n-6 PUFA on blood lipids when co-administered with n-3 PUFA(Elsevier, 2014-12-12) Dias CB; Wood LG; Garg MLBackground/Aims: The influence of diets rich in saturated fatty acids (SFA) or n-6PUFA in modulating blood lipid levels remains unclear. Recently we hypothesised that the lipemic effects of saturated fats are dependent on n-3PUFA status. This study aimed to examine the effects of consuming diets rich in SFA or n-6PUFA when co-administered with marine n-3PUFA. Methods: This was a randomised, controlled, parallel, dietary intervention trial involving 16 healthy adults aged 18 to 65 years. Subjects consumed a diet high in either SFA or n-6PUFA, each supplemented with 2.4g n-3PUFA daily for 6 weeks. Blood samples were collected after an overnight fast, at baseline and post-intervention, for analysis of blood lipid profile. Results: A reduction in plasma triglyceride levels was noted post-intervention, which was similar following consumption of the SFA+n-3PUFA or the n-6PUFA+n-3PUFA diets (28% versus 27% respectively). The SFA diet caused a significant rise in LDL (P=0.043) and HDL-cholesterol (P=0.05), while the n-6PUFA had no effect on LDL or HDL-cholesterol levels. Total/HDL-cholesterol or LDL/HDL-cholesterol ratios were not significantly different post-intervention for either of the diets. The change in total/HDL-cholesterol or LDL/HDL-cholesterol ratios following SFA diet was also similar to those on n-6PUFA diet. Conclusions: Dietary SFA and n-6PUFA differentially modulates plasma lipid profile when co-administered with n-3PUFA. The mechanism and consequence of concomitant increase in HDL and LDL-cholesterol following saturated fat consumption in association with n-3PUFA are worthy of further examination. Funding source(s): CBD was supported by a scholarship from the Coordenação Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
- ItemOmega-3 polyunsaturated fatty acids alleviate dietary saturated fat-induced postprandial rise in blood lipid levels(MDPI, 2013-12-12) Dias CB; Wood LG; Phang M; Garg ML