Browsing by Author "Stanton C"

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Editors' Prelude to Microbiome Research Reports.
(OAE Publishing, 2021-07-20) Ventura M; van Sinderen D; Turroni F; Milani C; Munoz J; Haller D; Ross RP; Collado MC; Allen-Vercoe E; Del Rio D; Altermann E; Katayama T; Zoetendal EG; Belzer C; Mena P; Im S-H; Gueimonde M; Margolles A; Ruiz L; Lacroix C; Stanton C; Barbara G; Saminen S; Scott KP; Barrangou R; Bottacini F; Marco ML
It is our sincere pleasure to introduce a new scientific journal named Microbiome Research Reports (acronym MRR), born out of an ambitious initiative from the Editorial Board of this new journal. Our motivation to initiate a new journal on microbiome research was driven by the importance and impact of the microbiome for human and planetary health, with related research interest and effort driven by the scientific community on the subject. In fact, research findings on this subject represent a Copernican Revolution influencing all research branches of the Life Sciences. For example, vast efforts are currently invested in elucidating potential links between microbiome and disease, which could lead to the discovery of microbial biomarkers for novel therapeutic and preventative strategies. We feel that it is very timely to launch a new journal focusing on Microbiome studies in humans and other animals, i.e., both wild- and domesticated- animals, being convinced that it will be a platform for the dissemination of microbiome discoveries.
Extensive bacteriocin gene shuffling in the Streptococcus bovis/Streptococcus equinus complex reveals gallocin D with activity against vancomycin resistant enterococci.
(Springer Nature Limited, 2020-08-10) Hill D; O'Connor PM; Altermann E; Day L; Hill C; Stanton C; Ross RP
Streptococcus gallolyticus LL009 produces gallocin D, a narrow spectrum two component bacteriocin with potent activity against vancomycin-resistant enterococci. Gallocin D is distinct from gallocin A, a separate two component bacteriocin produced by S. gallolyticus. Although the gene clusters encoding gallocin A and gallocin D have a high degree of gene synteny, the structural genes are highly variable and appear to have undergone gene shuffling with other streptococcal species. Gallocin D was analysed in laboratory-based experiments. The mature peptides are 3,343 ± 1 Da and 3,019 ± 1 Da and could be readily synthesized and display activity against a vancomycin resistant Enterococcus strain EC300 with a MIC value of 1.56 µM. Importantly, these bacteriocins could contribute to the ability of S. gallolyticus to colonize the colon where they have been associated with colorectal cancer.
Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction
(Springer Nature Limited, 2019-10-01) Bassett SA; Young W; Fraser K; Dalziel JE; Webster J; Ryan L; Fitzgerald P; Stanton C; Dinan TG; Cryan JF; Clarke G; Hyland N; Roy NC
Stress negatively impacts gut and brain health. Individual differences in response to stress have been linked to genetic and environmental factors and more recently, a role for the gut microbiota in the regulation of stress-related changes has been demonstrated. However, the mechanisms by which these factors influence each other are poorly understood, and there are currently no established robust biomarkers of stress susceptibility. To determine the metabolic and microbial signatures underpinning physiological stress responses, we compared stress-sensitive Wistar Kyoto (WKY) rats to the normo-anxious Sprague Dawley (SD) strain. Here we report that acute stress-induced strain-specific changes in brain lipid metabolites were a prominent feature in WKY rats. The relative abundance of Lactococcus correlated with the relative proportions of many brain lipids. In contrast, plasma lipids were significantly elevated in response to stress in SD rats, but not in WKY rats. Supporting these findings, we found that the greatest difference between the SD and WKY microbiomes were the predicted relative abundance of microbial genes involved in lipid and energy metabolism. Our results provide potential insights for developing novel biomarkers of stress vulnerability, some of which appear genotype specific.