Lactosylated polymers for tissue engineering : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Chemistry at Massey University
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Date
2006
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Massey University
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Abstract
This thesis describes the synthesis of new polymers suitable for the support of in vitro hepatocyte growth. The key design feature of the monomers investigated was the incorporation of a galactose residue, expected to promote the adhesion and proliferation of hepatocytes in vitro, through the regioselective derivation of lactose. A graft polymerisation strategy was investigated as an alternative to co-polymerization, since it proved difficult to isolate the carbohydrate-derived monomers in sufficient purity. This led to the formation of a glutaraldehyde-crosslinked lactosylated polyamine hydrogel, which was found to perform well in initial cell trials.
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Biopolymers, Tissue engineering