Occurrence and distribution of extended spectrum β-lactamase and AmpC-β-lactamase-producing Enterobacteriaceae and methicillin resistant Staphylococcus aureus in companion animals in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
The increasing incidence of infections with extended spectrum-lactamase
(ESBL)- and AmpC-producing Enterobacteriaceae, and methicillin-resistant
Staphylococcus aureus (MRSA) in humans in the last decade is a matter of
concern. There is a paucity of data on the incidence of infections with these
bacteria in animals, partly because veterinary diagnostic laboratories do not
routinely test for these organisms in clinical specimens. The carriage rate of
these bacteria by companion animals is also unknown.
This PhD project aimed to investigate the occurrence of ESBL/AmpCproducing
Enterobacteriaceae and MRSA in clinical specimens from animals
in New Zealand, and examine the carriage of multidrug-resistant (MDR),
ESBL/AmpC-E. coli, and MRSA in cats and dogs in Auckland.
The results of this project indicate that ESBL/AmpC-producing E. coli and
MRSA cause clinical infections in companion animals in New Zealand. The
circulation of these bacteria is likely to be posing therapeutic challenges to
unaware veterinarians. The bacteria causing infections or carried by
companion animals are genetically similar to those found in humans in New
Zealand, raising public health concerns about the role of carrier animals as
potential sources of zoonotic infections.