Synergistic Responses of Tibetan Sheep Rumen Microbiota, Metabolites, and the Host to the Plateau Environment.

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dc.citation.issue19
dc.citation.volume24
dc.contributor.authorSha Y
dc.contributor.authorGuo X
dc.contributor.authorHe Y
dc.contributor.authorLi W
dc.contributor.authorLiu X
dc.contributor.authorZhao S
dc.contributor.authorHu J
dc.contributor.authorWang J
dc.contributor.authorLi S
dc.contributor.authorZhao Z
dc.contributor.authorHao Z
dc.contributor.editorMiccheli A
dc.contributor.editorDocea AO
dc.contributor.editorFukui H
dc.coverage.spatialSwitzerland
dc.date.accessioned2025-01-08T00:17:43Z
dc.date.available2025-01-08T00:17:43Z
dc.date.issued2023-10-03
dc.description.abstractPlateau adaptation in animals involves genetic mechanisms as well as coevolutionary mechanisms of the microbiota and metabolome of the animal. Therefore, the characteristics of the rumen microbiome and metabolome, transcriptome, and serum metabolome of Tibetan sheep at different altitudes (4500 m, 3500 m, and 2500 m) were analyzed. The results showed that the rumen differential metabolites at 3500 m and 4500 m were mainly enriched in amino acid metabolism, lipid metabolism, and carbohydrate metabolism, and there was a significant correlation with microbiota. The differentially expressed genes and metabolites at middle and high altitudes were coenriched in asthma, arachidonic acid metabolism, and butanoate and propanoate metabolism. In addition, the serum differential metabolites at 3500 m and 4500 m were mainly enriched in amino acid metabolism, lipid metabolism, and metabolism of xenobiotics by cytochrome P450, and they were also related to microbiota. Further analysis revealed that rumen metabolites accounted for 7.65% of serum metabolites. These common metabolites were mainly enriched in metabolic pathways and were significantly correlated with host genes (p < 0.05). This study found that microbiota, metabolites, and epithelial genes were coenriched in pathways related to lipid metabolism, energy metabolism, and immune metabolism, which may be involved in the regulation of Tibetan sheep adaptation to plateau environmental changes.
dc.description.confidentialfalse
dc.edition.editionOctober-1 2023
dc.format.pagination14856-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37834304
dc.identifier.citationSha Y, Guo X, He Y, Li W, Liu X, Zhao S, Hu J, Wang J, Li S, Zhao Z, Hao Z. (2023). Synergistic Responses of Tibetan Sheep Rumen Microbiota, Metabolites, and the Host to the Plateau Environment.. Int J Mol Sci. 24. 19. (pp. 14856-).
dc.identifier.doi10.3390/ijms241914856
dc.identifier.eissn1422-0067
dc.identifier.elements-typejournal-article
dc.identifier.issn1661-6596
dc.identifier.number14856
dc.identifier.piiijms241914856
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/72330
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/1422-0067/24/19/14856
dc.relation.isPartOfInt J Mol Sci
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTibetan sheep
dc.subjecthost
dc.subjectmetabolites
dc.subjectmicrobial
dc.subjectrumen
dc.subjectserum
dc.subjectAnimals
dc.subjectSheep
dc.subjectRumen
dc.subjectTibet
dc.subjectMicrobiota
dc.subjectMetabolome
dc.subjectAmino Acids
dc.titleSynergistic Responses of Tibetan Sheep Rumen Microbiota, Metabolites, and the Host to the Plateau Environment.
dc.typeJournal article
pubs.elements-id481004
pubs.organisational-groupOther
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