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- ItemNutritional composition of New Zealand native shrubs edible portions with fodder potential for ruminants(Taylor and Francis Group, 2024-11-13) Wangui JC; Pain SJ; Kenyon PR; Tozer PR; Simmonds G; Millner JPIn New Zealand, willow and poplar are used on hill farms for erosion control and to supplement pasture during low pasture periods. Some native shrubs are browsed by wild herbivores but remain unexplored for farmed ruminants. We evaluated the seasonal nutritional composition of five native New Zealand shrubs (Karamū, Pāpāuma, Karo, Whauwhaupaku, and Houhere) and compared them with willow (Kinuyanagi). Leaf and edible stem were analysed for nutritional composition and in vitro digestibility following AOAC procedures. Results showed that except Houhere, all other native shrubs leaves had lower crude protein (CP) (11 MJ/ kg DM) than Kinuyanagi. Kinuyanagi leaves were comparable to Houhere in ME and CP in spring but had lower CP in summer. Stem nutritional composition was similar across all shrubs. Acid and neutral detergent fibres in edible portions were comparable to those in common pastures, fodder crops, and forages in New Zealand. The findings suggest native shrubs could supplement low ME in summer pastures or winter herbage scarcity, but further research is needed on animal preference and intake.
- ItemAlcohol-related harms now available on demand(Public Health Communication Centre, 2024-08-15) Burke S; Roseveare C; Wilson NAlcohol is one of the major causes of health loss in Aotearoa NZ. It is now available at people's fingertips through online on-demand delivery – within two hours from ordering. This Briefing summarises the evidence for potential harm that this easy access may contribute to. It also describes some of the regulatory reforms to alcohol legislation that the NZ Government could enact to address this risk to health and wellbeing.
- ItemNew Zealand ethical consumption driven by universalism and personal achievement; can it also be fun?(Taylor and Francis Group on behalf of the Royal Society of New Zealand, 2024-10-24) Hasan S; Wooliscroft B; Ganglmair-Wooliscroft AOverconsumption and environmental pollution in New Zealand are leading to the depletion of its resources, threatening its ecosystem. This paper explores New Zealanders’ ethical and sustainable consumption behaviour, and the motivations and values that drive them. Seventy in-depth interviews with a variety of ethical consumers were conducted and analysed using laddering technique to uncover drivers behind ethical consumption habits. Results reflect the complexity and variety inherent in ethical consumption, and its motivations and drivers. Most ethical behaviours are environmentally focused, aimed at pollution reduction and environmental conservation. Ethical behaviours with a social focus are directed at the local or the international community. Social justice, equality and unity of nature (all sub-values of universalism) are revealed as drivers of ethical behaviours, and are complemented by personal achievement (feeling capable) and feelings of enjoyment–consuming ethically can also be ‘fun’. The complexity of the findings highlights the need for customised messaging from policymakers and businesses to increase ethical consumption behaviours in New Zealand.
- ItemEconomic burden of patients with leading cancers in China: a cost-of-illness study.(BioMed Central Ltd, 2024-09-27) Wu Z; Yu Y; Xie F; Chen Q; Cao Z; Chen S; Liu GGBACKGROUND: China accounts for 24% of newly diagnosed cancer cases and 30% of cancer-related deaths worldwide. Comprehensive analyses of the economic burden on patients across different cancer treatment phases, based on empirical data, are lacking. This study aims to estimate the financial burden borne by patients and analyze the cost compositions of the leading cancers with the highest number of new cases in China. METHODS: This cross-sectional cost-of-illness study analyzed patients diagnosed with lung, breast, colorectal, esophageal, liver, or gastric cancer, identified through electronic health records (EHRs) from 84 hospitals across 17 provinces in China. Patients completed any one of the initial treatment phase, follow-up phase, and relapse/metastasis phase were recruited by trained attending physicians through a stratified sampling procedure to ensure enough cases for each cancer progression stage and cancer treatment phase. Direct and indirect costs by treatment phase were collected from the EHRs and self-reported surveys. We estimated per case cost for each type of cancer, and employed subgroup analyses and multiple linear regression models to explore cost drivers. RESULTS: We recruited a total of 13,745 cancer patients across three treatment phases. The relapse/metastasis phase incurred the highest per case costs, varying from $8,890 to $14,572, while the follow-up phase was the least costly, ranging from $1,840 to $4,431. Being in the relapse/metastasis phase and having an advanced clinical stage of cancer at diagnosis were associated with significantly higher cost, while patients with low socioeconomic status borne lower costs. CONCLUSIONS: There were substantial financial burden on patients with six leading cancers in China. Health policymakers should emphasize comprehensive healthcare coverage for marginalized populations such as the uninsured, less educated, and those living in underdeveloped regions.
- ItemIdentifying barriers to installing above-ground rainwater tanks in urban households in Aotearoa New Zealand: a segmentation approach(Informa UK Limited, trading as Taylor & Francis Group, 2024-09-05) McLeod LJ; Dorner Z; Hine DW; Kitson JC; Milfont TL; Stahlmann-Brown P; Tassell-Matamua NAUrbanisation poses numerous challenges to fresh water biodiversity, and installation of above-ground rainwater tanks on private properties is one important tool for addressing these challenges. In this paper, we used an online survey targeting a representative sample of 1291 urban residents to investigate their underlying capabilities, opportunities, and motivations for installation of above-ground rainwater tanks on their properties. Only 221 (17%) of the 1,291 respondents already had an above-ground rainwater tank installed on their property. By segmenting on behavioural variables, we found that those urban residents who currently did not have a water tank on their property were not homogeneous. We identified three audience segments, ‘Supportive’ (19%), ‘Receptive’ (59%) and ‘Reluctant’ (22%), each with their own unique driver and barrier combination to rainwater tank installation. Suitable leverage points and behaviour change tools (e.g. education, enablement, incentivisation) and message framing (environmental, community, or functional benefits) are identified for each segment.
- ItemA review of once-a-day milking in dairy cow grazing systems(Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association, 2023-07-13) Lopez-Villalobos N; Jayawardana JMDR; McNaughton LR; Hickson RETwice-a-day (TAD) milking during the whole lactation is practiced in about 55% of New Zealand herds and once-a-day (OAD) milking during the whole lactation in about 10% of herds. The remainder of farmers use a mixture of TAD and OAD. Results from long-term comparisons show that over a full-lactation cows milked OAD, on average, had lower yields of milk (27%), fat (23%), and protein (24%) and higher percentages of fat and protein than cows milked TAD, but cows milked OAD for the entire lactation had better reproductive performance. Herds of cows milked OAD have higher mean 3-wk submission rate, 6-wk in-calf rate, and conception to the first service, and lower not-in-calf rate than the herds of cows milked TAD for the entire lactation. Farmers that have adopted OAD milking have culled cows that are unsuitable for OAD, and used sires selected on a OAD selection index to produce cow replacements that are more suitable for OAD milking. This OAD index includes the same traits that are included in the New Zealand national selection index with different relative economic weights on these traits plus including udder support, front teat placement, milking speed, and body capacity. A pasture-based milk production system based on OAD can be an alternative for many dairy farmers to maintain or increase farm profitability, with the additional benefits of better cow fertility and flexibility of using labor.
- ItemInvited review: Bovine colostrum, a promising ingredient for humans and animals-Properties, processing technologies, and uses(Elsevier, 2023-08) Costa A; Sneddon NW; Goi A; Visentin G; Mammi LME; Savarino EV; Zingone F; Formigoni A; Penasa M; De Marchi MMammalian colostrum, known as "liquid gold," is considered a valuable source of essential nutrients, growth factors, probiotics, prebiotics, antibodies, and other bioactive compounds. Precisely for this reason, bovine colostrum (BC) is an emerging ingredient for the feed, food, and pharmaceutical industries, being nowadays commercially available in a variety of forms in several countries. Moreover, quite a large number of functional foods and supplements for athletes, human medicines, pet nutrition plans, and complementary feed for some livestock categories, such as piglets and calves, contain BC. The amount of BC yielded by a cow after calving represents approximately 0.5% of the yearly output in dairy breeds. For its nutritional properties and low availability, BC is characterized by a greater market value and an increasing demand compared with other by-products of the dairy sector. However, information regarding the market size of BC for the food and pharmaceutical industries, as well as future developments and perspectives, is scarcely available in the scientific literature. This lack can be attributed to industrial secrecy as well as to the relatively small scale of the BC business when compared with other dairy products, which makes the BC market limited, specific, and intended for a restricted audience. From a legal perspective, regulations assign BC to the large family of milk-derived powders; thus, collecting specific production data, as well as import-export trend information, is not straightforward and can result in unprecise estimates. Given that the interest in BC is increasing in different fields, it is important to have an overview of the production steps and of pros and cons of this emerging ingredient. The present narrative review discloses why BC has started to be considered a product rather than a by-product of the dairy industry. Moreover, the present document aims to summarize the existing methodologies used to assess BC quality in terms of immunoglobulin concentration, the different applications of BC in the industry, and the BC processing technologies. Finally, a panoramic view of the current international market is provided for the first time for this dairy product.
- ItemGenomic and culture-based analysis of Cyclaneusma minus in New Zealand provides evidence for multiple morphotypes(BioMed Central Ltd, 2024-12) Tarallo M; Dobbie KB; Leite LN; Waters TL; Gillard KNT; Sen D; Mesarich CH; Bradshaw RE; McDougal RLCyclaneusma needle cast, caused by Cyclaneusma minus, affects Pinus species world wide. Previous studies suggested the presence of two distinct morphotypes in New Zealand, ‘verum’ and ‘simile’. Traditional mycological analyses revealed a third morphotype with clear differences in colony morphology and cardinal growth rates at varying temperatures. Genome sequencing of eight C. minus isolates provided further evidence of the existence of a third morphotype, named as ‘novus’ in this study. To further analyse these morphotypes, we predicted candidate effector proteins for all eight isolates, and also characterized a cell-death eliciting effector family, Ecp32, which is present in other pine phytopathogens. In concordance with their distinct classification into three different morphotypes, the number of Ecp32 family members differed, with patterns of pseudogenization in the ‘simile’ morphotype, and some members being found exclusively either in the ‘simile’ or ‘verum’ morphotypes. We also showed that the Ecp32 family proteins trigger cell death in non-host Nicotiana species, and, as previously demonstrated in other plant pathogens, the Ecp32 family proteins in C. minus adopt a β-trefoil fold. These analyses provide further evidence that the three morphotypes might be distinct species that need formal descriptions. Understanding the geographical range of different Cyclaneusma species and variations in virulence and pathogenicity will provide a better understanding of pine needle diseases and enable the development of more durable methods to control this disease.
- ItemMulti-modal sleep intervention for community-dwelling people living with dementia and primary caregiver dyads with sleep disturbance: protocol of a single-arm feasibility trial(PeerJ Inc., 2023-01-01) Verma S; Varma P; Brown A; Bei B; Gibson R; Valenta T; Pietsch A; Cavuoto M; Woodward M; McCurry S; Jackson ML; Keogh JBackground. Disturbed sleep is common among people living with dementia and their informal caregivers, and is associated with negative health outcomes. Dyadic, multi-modal interventions targeting caregiver and care-recipient sleep have been recommended yet remain limited. This protocol details the development of a singlearm feasibility trial of a multi-modal, therapist-led, six-week intervention targeting sleep disturbance in dyads of people living with dementia and their primary caregiver. Methods. We aim to recruit 24 co-residing, community-dwelling dyads of people living with dementia and their primary informal caregiver (n D 48) with sleep concerns (Pittsburgh Sleep Quality Index ≥5 for caregivers, and caregiver-endorsed sleep concerns for the person living with dementia). People who live in residential care settings, are employed in night shift work, or are diagnosed with current, severe mental health conditions or narcolepsy, will be excluded. Participants will wear an actigraph and complete sleep diaries for two weeks prior, and during the last two weeks, of active intervention. The intervention is therapist-led and includes a mix of weekly small group video sessions and personalised, dyadic sessions (up to 90 min each) over six weeks. Sessions are supported by a 37-page workbook offering strategies and spaces for reflections/notes. Primary feasibility outcomes are caregiver: session attendance, attrition, and self-reported project satisfaction. Secondary outcomes include dyadic self-reported and objectively-assessed sleep, depression and anxiety symptoms, quality of life, and social support. Self-report outcomes will be assessed at pre- and postintervention. Discussion. If feasible, this intervention could be tested in a larger randomised controlled trial to investigate its efficacy, and, upon further testing, may potentially represent a non-pharmacological approach to reduce sleep disturbance among people living with dementia and their caregivers.
- ItemPangenome graphs in infectious disease: a comprehensive genetic variation analysis of Neisseria meningitidis leveraging Oxford Nanopore long reads.(Frontiers Media S.A., 2023-08-10) Yang Z; Guarracino A; Biggs PJ; Black MA; Ismail N; Wold JR; Merriman TR; Prins P; Garrison E; de Ligt J; Hane JWhole genome sequencing has revolutionized infectious disease surveillance for tracking and monitoring the spread and evolution of pathogens. However, using a linear reference genome for genomic analyses may introduce biases, especially when studies are conducted on highly variable bacterial genomes of the same species. Pangenome graphs provide an efficient model for representing and analyzing multiple genomes and their variants as a graph structure that includes all types of variations. In this study, we present a practical bioinformatics pipeline that employs the PanGenome Graph Builder and the Variation Graph toolkit to build pangenomes from assembled genomes, align whole genome sequencing data and call variants against a graph reference. The pangenome graph enables the identification of structural variants, rearrangements, and small variants (e.g., single nucleotide polymorphisms and insertions/deletions) simultaneously. We demonstrate that using a pangenome graph, instead of a single linear reference genome, improves mapping rates and variant calling for both simulated and real datasets of the pathogen Neisseria meningitidis. Overall, pangenome graphs offer a promising approach for comparative genomics and comprehensive genetic variation analysis in infectious disease. Moreover, this innovative pipeline, leveraging pangenome graphs, can bridge variant analysis, genome assembly, population genetics, and evolutionary biology, expanding the reach of genomic understanding and applications.
