Does Viagra protect fetal lambs against maternal pregnancy toxaemia?

dc.contributor.authorPeterson, SWen_US
dc.contributor.authorPain, SJen_US
dc.contributor.authorMcCoard, SAen_US
dc.contributor.authorOliver, Men_US
dc.contributor.authorBaker, PBen_US
dc.contributor.authorKenyon, PRen_US
dc.contributor.authorBlair, HTen_US
dc.coverage.spatialAdelaide, Australiaen_US
dc.description.abstractPoor fetal growth is commonly caused by placental insufficiency. In sheep, multiple fetuses have relatively small placentae with fewer cotyledons than singletons, limiting blood flow to the placenta, especially in late gestation when fetal growth rate is highest. Factors that reduce fetal growth, such as maternal genotype, nutrition, age, parity, fetal number, or environmental temperature, typically reduce placental size and are associated with lower rates of fetal oxygen and nutrient uptakes and placental blood flow (Reynolds & Redmer 2001). Further, circumstances that influence placental vascular development have a dramatic impact on fetal growth and development, and affect neonatal survival and growth (Borowicz et al. 2007; Satterfield et al, 2010). Sildenafil citrate (SC, trade names Viagra or Avigra) increases vasodilatation of uteroplacental vessels (Wareing et al. 2005) and may represent a novel therapy to improve fetal lamb growth. Sildenafil citrate has successfully increased birth weight in rodent models and singleton bearing ewes (Satterfield et al. 2010; Miller at al. 2009). There is no published information regarding the use of SC in multiple-bearing ewes. The objective of this trial was to determine if SC administration to triplet-bearing ewes in late gestation could increase lamb birth weight. In addition, the influence of SC on the incidence of pregnancy toxaemia is also reported here.en_US
dc.format.extent172 - 174en_US
dc.identifier.citationProceedings of the New Zealand Society of Animal Production, 2016, 76 pp. 172 - 174en_US
dc.publisherNew Zealand Society of Animal Productionen_US
dc.relation.isPartOfProceedings of the New Zealand Society of Animal Productionen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
dc.sourceNew Zealand Society of Animal Productionen_US
dc.subjectsildenafil citrateen_US
dc.subjectpregnant ewesen_US
dc.subjectpregnancy toxaemiaen_US
dc.subjectlamb survivalen_US
dc.subject.anzsrc0702 Animal Productionen_US
dc.titleDoes Viagra protect fetal lambs against maternal pregnancy toxaemia?en_US
dc.typeConference Paper
pubs.notesNot knownen_US
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Agriculture & Environment
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