Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review

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dc.citation.issue2
dc.citation.volume14
dc.contributor.authorRees G
dc.contributor.authorBrough L
dc.contributor.authorOrsatti GM
dc.contributor.authorLodge A
dc.contributor.authorWalker S
dc.contributor.editorPérez-Cano FJ
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-10-12T23:53:46Z
dc.date.accessioned2023-10-19T20:38:29Z
dc.date.available2022-01-15
dc.date.available2023-10-12T23:53:46Z
dc.date.available2023-10-19T20:38:29Z
dc.date.issued2022-01-15
dc.date.updated2023-10-12T23:45:16Z
dc.description.abstractMaternal dietary micronutrients and omega-3 fatty acids support development of the fetal and neonatal immune system. Whether supplementation is similarly beneficial for the mother during gestation has received limited attention. A scoping review of human trials was conducted looking for evidence of biochemical, genomic, and clinical effects of supplementation on the maternal immune system. The authors explored the literature on PubMed, Cochrane Library, and Web of Science databases from 2010 to the present day using PRISMA-ScR methodology. Full-length human trials in English were searched for using general terms and vitamin A, B12, C, D, and E; choline; iodine; iron; selenium; zinc; and docosahexaenoic/eicosapentaenoic acid. Of 1391 unique articles, 36 were eligible for inclusion. Diverse biochemical and epigenomic effects of supplementation were identified that may influence innate and adaptive immunity. Possible clinical benefits were encountered in malaria, HIV infections, anemia, Type 1 diabetes mellitus, and preventing preterm delivery. Only limited publications were identified that directly explored maternal immunity in pregnancy and the effects of micronutrients. None provided a holistic perspective. It is concluded that supplementation may influence biochemical aspects of the maternal immune response and some clinical outcomes, but the evidence from this review is not sufficient to justify changes to current guidelines.
dc.description.confidentialfalse
dc.edition.editionJanuary 2022
dc.format.extent367-
dc.identifierARTN 367
dc.identifiernu14020367
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35057548
dc.identifier.citationRees G, Brough L, Orsatti GM, Lodge A, Walker S. (2022). Do Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review.. Nutrients. 14. 2. (pp. 367-).
dc.identifier.doi10.3390/nu14020367
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10179/20322
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/14/2/367
dc.relation.isPartOfNutrients
dc.rights(c) 2022 The Author/sen_US
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectimmunity
dc.subjectmicronutrients
dc.subjectpregnancy
dc.subjectscoping review
dc.subjectsupplementation
dc.subjectAdult
dc.subjectAnemia
dc.subjectCholine
dc.subjectDiabetes Mellitus, Type 1
dc.subjectDietary Supplements
dc.subjectFatty Acids, Omega-3
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectImmune System
dc.subjectIodine
dc.subjectIron
dc.subjectMaternal Health
dc.subjectMicronutrients
dc.subjectMothers
dc.subjectPregnancy
dc.subjectPrenatal Nutritional Physiological Phenomena
dc.subjectSelenium
dc.subjectTrace Elements
dc.subjectVitamins
dc.subjectZinc
dc.titleDo Micronutrient and Omega-3 Fatty Acid Supplements Affect Human Maternal Immunity during Pregnancy? A Scoping Review
dc.typeJournal article
pubs.elements-id450785
pubs.organisational-groupOther
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