An alternative combination therapy with metronidazole, clindamycin and doxycycline for Babesia gibsoni (Asian genotype) in dogs in Hong Kong

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dc.citation.issue9
dc.citation.volume82
dc.contributor.authorAlmendros A
dc.contributor.authorBurchell R
dc.contributor.authorWierenga J
dc.date.available2020-08-04
dc.date.issued2020-10-07
dc.description.abstractBabesia spp. are globally distributed hemoparasites that cause disease in many mammalian species. The species Babesia gibsoni (Asian genotype) is prevalent and endemic in many Asian countries but has been reported in growing numbers in countries outside of Asia. Standard therapies for the treatment of B. gibsoni often fail to result in consistent and successful clearance of the organism. This study evaluated the use of a combination of three antibiotics: metronidazole, clindamycin and doxycycline after atovaquone and azithromycin failed to eliminate the infection on a polymerase chain reaction (PCR) test. The aim of this study was to determine whether the triple antibiotic combination was an appropriate alternative or additional treatment for the elimination of B. gibsoni. The medical records of 24 patients treated form December 2012 to July 2015 were retrospectively analyzed. The diagnosis of B. gibsoni was confirmed with a PCR test that was also used to assess treatment response. All patients were initially treated with the standard therapy, atovaquone and azithromycin with a 25% success rate clearing B. gibsoni. Dogs that remained positive on PCR using the standard therapy were then treated with the triple antibiotic protocol achieving an 87% success rate. The inclusion of an alternative and potentially effective protocol for the treatment of B. gibsoni would increase the options for the current therapeutic options, could aid in clearance of the organism and offer a more affordable option for clients.
dc.description.confidentialfalse
dc.format.extent1334 - 1340
dc.identifier.citationThe Journal of veterinary medical science / the Japanese Society of Veterinary Science, 2020, 82 (9), pp. 1334 - 1340
dc.identifier.doi10.1292/jvms.20-0209
dc.identifier.elements-id435628
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0916-7250
dc.publisherJapanese Society of Veterinary Science
dc.relation.isPartOfThe Journal of veterinary medical science / the Japanese Society of Veterinary Science
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.anzsrc0707 Veterinary Sciences
dc.titleAn alternative combination therapy with metronidazole, clindamycin and doxycycline for Babesia gibsoni (Asian genotype) in dogs in Hong Kong
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/School of Veterinary Science
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