Genomic Characterisation of Canis Familiaris Papillomavirus Type 24, a Novel Papillomavirus Associated with Extensive Pigmented Plaque Formation in a Pug Dog

Simple item page
dc.citation.issue11
dc.citation.volume14
dc.contributor.authorMunday JS
dc.contributor.authorGedye K
dc.contributor.authorKnox MA
dc.contributor.authorRavens P
dc.contributor.authorLin X
dc.contributor.editorDalianis T
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-02-01T02:17:16Z
dc.date.accessioned2024-07-25T06:48:06Z
dc.date.available2022-10-26
dc.date.available2024-02-01T02:17:16Z
dc.date.available2024-07-25T06:48:06Z
dc.date.issued2022-10-26
dc.description.abstractNumerous large dark plaques developed over the ventrum, legs and head of a 9-year-old pug dog over a 4-year-period. Histology confirmed a diagnosis of viral pigmented plaque and a short section of a novel papillomavirus (PV) type was amplified using consensus PCR primers. Taking advantage of the circular nature of PV DNA, 'outward facing' PCR primers allowed amplification of the full sequence. As this is the 24th PV known to infect dogs, the novel PV was designated canine papillomavirus (CPV) type 24. The CPV24 genome contained putative coding regions for 5 early proteins and 2 late ones. The CPV24 open reading frame L1 showed the highest (78.2%) similarity to CPV4 and phylogenetic analysis showed that CPV24 clustered with CPV4 and CPV16 suggesting CPV24 is the third species 2 Chipapillomavirus type identified in dogs. This is the third report of extensive pigmented plaques covering a high proportion of the skin. Both previous cases were caused CPV4 and, considering the high genetic similarity between CPV4 and CP24, infection by these CPV types may predispose to more severe clinical disease. In addition, as plaques caused by CPV16 appear more likely to progress to neoplasia, the detection of a species 2 Chipapillomavirus within a pigmented plaque may indicate the potential for more severe disease.
dc.description.confidentialfalse
dc.edition.editionNovember 2022
dc.format.pagination2357-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36366455
dc.identifier.citationMunday JS, Gedye K, Knox MA, Ravens P, Lin X. (2022). Genomic Characterisation of Canis Familiaris Papillomavirus Type 24, a Novel Papillomavirus Associated with Extensive Pigmented Plaque Formation in a Pug Dog.. Viruses. 14. 11. (pp. 2357-).
dc.identifier.doi10.3390/v14112357
dc.identifier.eissn1999-4915
dc.identifier.elements-typejournal-article
dc.identifier.issn1999-4915
dc.identifier.number2357
dc.identifier.piiv14112357
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70909
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/1999-4915/14/11/2357
dc.relation.isPartOfViruses
dc.rights(c) 2022 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCPV24
dc.subjectcanine papillomavirus (CPV)
dc.subjectdog
dc.subjectneoplasia
dc.subjectpapillomavirus
dc.subjectpigmented plaque
dc.subjectskin
dc.subjectviral plaque
dc.subjectDogs
dc.subjectAnimals
dc.subjectPhylogeny
dc.subjectDNA, Viral
dc.subjectDog Diseases
dc.subjectPapillomaviridae
dc.subjectGenomics
dc.subjectDNA Primers
dc.subjectPapillomavirus Infections
dc.titleGenomic Characterisation of Canis Familiaris Papillomavirus Type 24, a Novel Papillomavirus Associated with Extensive Pigmented Plaque Formation in a Pug Dog
dc.typeJournal article
pubs.elements-id457877
pubs.organisational-groupOther
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Published version
Size:
1.15 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles