Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep

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dc.citation.issue1
dc.citation.volume14
dc.contributor.authorRamos Z
dc.contributor.authorGarrick DJ
dc.contributor.authorBlair HT
dc.contributor.authorVera B
dc.contributor.authorCiappesoni G
dc.contributor.authorKenyon PR
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-01-04T01:37:52Z
dc.date.accessioned2024-07-25T06:35:03Z
dc.date.available2023-01-07
dc.date.available2024-01-04T01:37:52Z
dc.date.available2024-07-25T06:35:03Z
dc.date.issued2023-01-07
dc.description.abstractThe aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE ≥ 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes.
dc.format.pagination167-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36672908
dc.identifier.citationRamos Z, Garrick DJ, Blair HT, Vera B, Ciappesoni G, Kenyon PR. (2023). Genomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep.. Genes (Basel). 14. 1. (pp. 167-).
dc.identifier.doi10.3390/genes14010167
dc.identifier.eissn2073-4425
dc.identifier.elements-typejournal-article
dc.identifier.issn2073-4425
dc.identifier.piigenes14010167
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70475
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfGenes (Basel)
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGWAS
dc.subjectbody condition score
dc.subjectfiber diameter
dc.subjectgene
dc.subjectreproduction
dc.subjectsheep
dc.subjectPregnancy
dc.subjectAnimals
dc.subjectSheep
dc.subjectFemale
dc.subjectWool
dc.subjectGenome-Wide Association Study
dc.subjectBayes Theorem
dc.subjectGenomics
dc.subjectSheep, Domestic
dc.subjectReproduction
dc.titleGenomic Regions Associated with Wool, Growth and Reproduction Traits in Uruguayan Merino Sheep
dc.typeJournal article
pubs.elements-id459104
pubs.organisational-groupOther
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