Inflammation and the Association of Vitamin D and Depressive Symptomatology.

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dc.citation.issue6
dc.citation.volume13
dc.contributor.authorDogan-Sander E
dc.contributor.authorMergl R
dc.contributor.authorWillenberg A
dc.contributor.authorBaber R
dc.contributor.authorWirkner K
dc.contributor.authorRiedel-Heller SG
dc.contributor.authorRöhr S
dc.contributor.authorSchmidt FM
dc.contributor.authorSchomerus G
dc.contributor.authorSander C
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-11-21T23:39:50Z
dc.date.accessioned2024-07-25T06:50:35Z
dc.date.available2021-06-08
dc.date.available2023-11-21T23:39:50Z
dc.date.available2024-07-25T06:50:35Z
dc.date.issued2021-06
dc.description.abstractDepression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (IL-6 and CRP levels, WBC count) were quantified. Mediation analyses were performed using Hayes’ PROCESS macro and regression analyses were conducted to test moderation effects. There was a significant negative correlation between CES-D and 25(OH)D, and positive associations between inflammatory markers and CES-D scores. Only WBC partially mediated the association between 25(OH)D levels and depressive symptoms both in a simple mediation model (ab: −0.0042) and a model including covariates (ab: −0.0011). None of the inflammatory markers showed a moderation effect on the association between 25(OH)D levels and depressive symptoms. This present work highlighted the complex relationship between vitamin D, depressive symptoms and inflammation. Future studies are needed to examine the effect of vitamin D supplementation on inflammation and depressive symptomatology for causality assessment.
dc.format.pagination1972-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34201276
dc.identifier.citationDogan-Sander E, Mergl R, Willenberg A, Baber R, Wirkner K, Riedel-Heller SG, Röhr S, Schmidt FM, Schomerus G, Sander C. (2021). Inflammation and the Association of Vitamin D and Depressive Symptomatology.. Nutrients. 13. 6. (pp. 1972-).
dc.identifier.doi10.3390/nu13061972
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.piinu13061972
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70992
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.relation.isPartOfNutrients
dc.rights(c) 2021 The Author/s
dc.rightsCC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLIFE-Adult-Study
dc.subjectdepression
dc.subjectinflammation
dc.subjectmediation
dc.subjectmoderation
dc.subjectvitamin D
dc.subjectAdult
dc.subjectAged
dc.subjectBiomarkers
dc.subjectDepression
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectModels, Biological
dc.subjectRegression Analysis
dc.subjectVitamin D
dc.subjectYoung Adult
dc.titleInflammation and the Association of Vitamin D and Depressive Symptomatology.
dc.typeJournal article
pubs.elements-id455080
pubs.organisational-groupOther
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