Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.

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dc.citation.issue1
dc.citation.volume21
dc.contributor.authorNimptsch K
dc.contributor.authorAleksandrova K
dc.contributor.authorPham TT
dc.contributor.authorPapadimitriou N
dc.contributor.authorJanke J
dc.contributor.authorChristakoudi S
dc.contributor.authorHeath A
dc.contributor.authorOlsen A
dc.contributor.authorTjønneland A
dc.contributor.authorSchulze MB
dc.contributor.authorKatzke V
dc.contributor.authorKaaks R
dc.contributor.authorvan Guelpen B
dc.contributor.authorHarbs J
dc.contributor.authorPalli D
dc.contributor.authorMacciotta A
dc.contributor.authorPasanisi F
dc.contributor.authorYohar SMC
dc.contributor.authorGuevara M
dc.contributor.authorAmiano P
dc.contributor.authorGrioni S
dc.contributor.authorJakszyn PG
dc.contributor.authorFigueiredo JC
dc.contributor.authorSamadder NJ
dc.contributor.authorLi CI
dc.contributor.authorMoreno V
dc.contributor.authorPotter JD
dc.contributor.authorSchoen RE
dc.contributor.authorUm CY
dc.contributor.authorWeiderpass E
dc.contributor.authorJenab M
dc.contributor.authorGunter MJ
dc.contributor.authorPischon T
dc.coverage.spatialEngland
dc.date.accessioned2024-06-03T23:53:17Z
dc.date.available2024-06-03T23:53:17Z
dc.date.issued2023-10-13
dc.description.abstractBACKGROUND: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach. METHODS: The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. RESULTS: In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37). CONCLUSIONS: Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further.
dc.description.confidentialfalse
dc.format.pagination391-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37833736
dc.identifier.citationNimptsch K, Aleksandrova K, Pham TT, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze MB, Katzke V, Kaaks R, van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar SMC, Guevara M, Amiano P, Grioni S, Jakszyn PG, Figueiredo JC, Samadder NJ, Li CI, Moreno V, Potter JD, Schoen RE, Um CY, Weiderpass E, Jenab M, Gunter MJ, Pischon T. (2023). Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.. BMC Med. 21. 1. (pp. 391-).
dc.identifier.doi10.1186/s12916-023-03104-1
dc.identifier.eissn1741-7015
dc.identifier.elements-typejournal-article
dc.identifier.issn1741-7015
dc.identifier.number391
dc.identifier.pii10.1186/s12916-023-03104-1
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69714
dc.languageeng
dc.publisherBioMed Central
dc.publisher.urihttps://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03104-1
dc.relation.isPartOfBMC Med
dc.rights(c) The author/sen
dc.rights.licenseCC BYen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectColorectal cancer
dc.subjectFABP-4
dc.subjectMendelian randomization
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectCase-Control Studies
dc.subjectColorectal Neoplasms
dc.subjectGenome-Wide Association Study
dc.subjectMendelian Randomization Analysis
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.titleProspective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.
dc.typeJournal article
pubs.elements-id481052
pubs.organisational-groupCollege of Health
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