Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control

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dc.citation.issue1
dc.citation.volume50
dc.contributor.authorSran SPK
dc.contributor.authorGartrell BG
dc.contributor.authorFisher P
dc.contributor.authorArmstrong DP
dc.contributor.editorBelmain S
dc.date.accessioned2024-01-25T19:11:39Z
dc.date.accessioned2024-07-25T06:49:46Z
dc.date.available2022-07-07
dc.date.available2024-01-25T19:11:39Z
dc.date.available2024-07-25T06:49:46Z
dc.date.issued2022-07-07
dc.description.abstractContext: Anticoagulants have been used in New Zealand for decades, but few data are available on the sustainability of these toxins for rodent control. It is important to regularly monitor for resistance in long-term brodifacoum-use areas and establish a database for future references. Aims: This study aimed to estimate the effective dose (ED50) of brodifacoum for ship rats from an area of New Zealand with no history of brodifacoum use, in order to establish a blood-clotting response test for assessing resistance in rodent populations from other areas. Methods: A ranging study was conducted whereby successive groups of ship rats were administered brodifacoum doses that were increased or decreased progressively, until an International Normalised Ratio (INR) of 3.6 was reached. Linear regression was used to model the relationship between dose and INR, and ED50 dose was estimated using the resulting model. Results: None of the rats appeared susceptible to brodifacoum at previously reported LD50 exposures for this species. The ED50 of brodifacoum was estimated to be 2.88 mg/kg for males and 3.81 mg/kg for females. These values are 6-8 times greater than the previously published lethal dose values for ship rats in New Zealand. Conclusions: Blood-clotting inhibition was detected in the rats only following high doses of brodifacoum, which may indicate resistance within the sampled population. Implications: Relatively low susceptibility, or resistance, to brodifacoum in New Zealand ship rats may be mediated by spatial connections between areas with different histories and patterns of anticoagulant rodenticide use.
dc.description.confidentialfalse
dc.format.pagination28-38
dc.identifier.citationSran SPK, Gartrell BG, Fisher P, Armstrong DP. (2022). Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control. Wildlife Research. 50. 1. (pp. 28-38).
dc.identifier.doi10.1071/WR21064
dc.identifier.eissn1448-5494
dc.identifier.elements-typejournal-article
dc.identifier.issn1035-3712
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70965
dc.languageEnglish
dc.publisherCSIRO Publishing
dc.publisher.urihttps://www.publish.csiro.au/wr/Fulltext/WR21064
dc.relation.isPartOfWildlife Research
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectanticoagulants
dc.subjectblood clotting response test
dc.subjectbrodifacoum
dc.subjecteffective dose
dc.subjectpest management
dc.subjectRattus rattus
dc.subjectresistance
dc.subjectrodent control
dc.titleApparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control
dc.typeJournal article
pubs.elements-id455210
pubs.organisational-groupOther
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