A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens

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dc.citation.issue1
dc.citation.volume19
dc.contributor.authorMoreira GCM
dc.contributor.authorBoschiero C
dc.contributor.authorCesar ASM
dc.contributor.authorReecy JM
dc.contributor.authorGodoy TF
dc.contributor.authorTrevisoli PA
dc.contributor.authorCantão ME
dc.contributor.authorLedur MC
dc.contributor.authorIbelli AMG
dc.contributor.authorPeixoto JDO
dc.contributor.authorMoura ASAMT
dc.contributor.authorGarrick D
dc.contributor.authorCoutinho LL
dc.coverage.spatialEngland
dc.date.accessioned2024-04-14T23:56:59Z
dc.date.accessioned2024-07-25T06:47:32Z
dc.date.available2018-05-21
dc.date.available2024-04-14T23:56:59Z
dc.date.available2024-07-25T06:47:32Z
dc.date.issued2018-05-21
dc.description.abstractBACKGROUND: Excess fat content in chickens has a negative impact on poultry production. The discovery of QTL associated with fat deposition in the carcass allows the identification of positional candidate genes (PCGs) that might regulate fat deposition and be useful for selection against excess fat content in chicken's carcass. This study aimed to estimate genomic heritability coefficients and to identify QTLs and PCGs for abdominal fat (ABF) and skin (SKIN) traits in a broiler chicken population, originated from the White Plymouth Rock and White Cornish breeds. RESULTS: ABF and SKIN are moderately heritable traits in our broiler population with estimates ranging from 0.23 to 0.33. Using a high density SNP panel (355,027 informative SNPs), we detected nine unique QTLs that were associated with these fat traits. Among these, four QTL were novel, while five have been previously reported in the literature. Thirteen PCGs were identified that might regulate fat deposition in these QTL regions: JDP2, PLCG1, HNF4A, FITM2, ADIPOR1, PTPN11, MVK, APOA1, APOA4, APOA5, ENSGALG00000000477, ENSGALG00000000483, and ENSGALG00000005043. We used sequence information from founder animals to detect 4843 SNPs in the 13 PCGs. Among those, two were classified as potentially deleterious and two as high impact SNPs. CONCLUSIONS: This study generated novel results that can contribute to a better understanding of fat deposition in chickens. The use of high density array of SNPs increases genome coverage and improves QTL resolution than would have been achieved with low density. The identified PCGs were involved in many biological processes that regulate lipid storage. The SNPs identified in the PCGs, especially those predicted as potentially deleterious and high impact, may affect fat deposition. Validation should be undertaken before using these SNPs for selection against carcass fat accumulation and to improve feed efficiency in broiler chicken production.
dc.description.confidentialfalse
dc.edition.editionDecember 2018
dc.format.pagination374-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29783939
dc.identifier.citationMoreira GCM, Boschiero C, Cesar ASM, Reecy JM, Godoy TF, Trevisoli PA, Cantão ME, Ledur MC, Ibelli AMG, Peixoto JDO, Moura ASAMT, Garrick D, Coutinho LL. (2018). A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens.. BMC Genomics. 19. 1. (pp. 374-).
dc.identifier.doi10.1186/s12864-018-4779-6
dc.identifier.eissn1471-2164
dc.identifier.elements-typejournal-article
dc.identifier.issn1471-2164
dc.identifier.numberARTN 374
dc.identifier.pii10.1186/s12864-018-4779-6
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70878
dc.languageeng
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://link.springer.com/article/10.1186/s12864-018-4779-6
dc.relation.isPartOfBMC Genomics
dc.rights(c) 2018 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAbdominal fat
dc.subjectFatness
dc.subjectGenomic heritability
dc.subjectQTL
dc.subjectSkin weight
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectChickens
dc.subjectGenome-Wide Association Study
dc.subjectGenomics
dc.subjectPhenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectQuantitative Trait Loci
dc.titleA genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens
dc.typeJournal article
pubs.elements-id428942
pubs.organisational-groupOther
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