Vitamin D and Autism Spectrum Disorder: A Literature Review.

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dc.citation.issue4
dc.citation.volume8
dc.contributor.authorMazahery H
dc.contributor.authorCamargo CA
dc.contributor.authorConlon C
dc.contributor.authorBeck KL
dc.contributor.authorKruger MC
dc.contributor.authorvon Hurst PR
dc.date.available2016-04
dc.date.available2016-04-14
dc.date.issued2016-04-21
dc.description.abstractLow vitamin D status in early development has been hypothesised as an environmental risk factor for Autism Spectrum Disorder (ASD), given the concurrent increase in the prevalence of these two conditions, and the association of vitamin D with many ASD-associated medical conditions. Identification of vitamin D-ASD factors may provide indications for primary and secondary prevention interventions. We systematically reviewed the literature for studies on vitamin D-ASD relationship, including potential mechanistic pathways. We identified seven specific areas, including: latitude, season of conception/birth, maternal migration/ethnicity, vitamin D status of mothers and ASD patients, and vitamin D intervention to prevent and treat ASD. Due to differences in the methodological procedures and inconsistent results, drawing conclusions from the first three areas is difficult. Using a more direct measure of vitamin D status--that is, serum 25(OH)D level during pregnancy or childhood--we found growing evidence for a relationship between vitamin D and ASD. These findings are supported by convincing evidence from experimental studies investigating the mechanistic pathways. However, with few primary and secondary prevention intervention trials, this relationship cannot be determined, unless randomised placebo-controlled trials of vitamin D as a preventive or disease-modifying measure in ASD patients are available.
dc.description.publication-statusPublished
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374590200058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=c5bb3b2499afac691c2e3c1a83ef6fef
dc.identifierARTN 236
dc.identifier.citationNUTRIENTS, 2016, 8 (4)
dc.identifier.doi10.3390/nu8040236
dc.identifier.eissn2072-6643
dc.identifier.elements-id261065
dc.identifier.harvestedMassey_Dark
dc.relation.isPartOfNUTRIENTS
dc.rightsCreative Commons Attribution License 4.0
dc.subjectreview
dc.subjectAutism Spectrum Disorder
dc.subjectASD
dc.subjectVitamin D
dc.subject25(OH)D
dc.subjectintervention
dc.subjectlatitude
dc.subjectethnicity
dc.subjectmigration
dc.subjectseason
dc.subjectbirth
dc.subjectconception
dc.subject.anzsrc0908 Food Sciences
dc.subject.anzsrc1111 Nutrition and Dietetics
dc.titleVitamin D and Autism Spectrum Disorder: A Literature Review.
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Health
pubs.organisational-group/Massey University/College of Health/School of Health Science
pubs.organisational-group/Massey University/College of Health/School of Sport, Exercise and Nutrition
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