Factors Associated with Bone Mineral Density and Bone Resorption Markers in Postmenopausal HIV-Infected Women on Antiretroviral Therapy: A Prospective Cohort Study

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dc.citation.issue6
dc.citation.volume13
dc.contributor.authorEllis C
dc.contributor.authorKruger HS
dc.contributor.authorViljoen M
dc.contributor.authorDave JA
dc.contributor.authorKruger MC
dc.contributor.editorWeaver C
dc.coverage.spatialSwitzerland
dc.date.accessioned2023-07-18T02:06:56Z
dc.date.accessioned2023-09-04T01:40:48Z
dc.date.available2021-06-18
dc.date.available2023-07-18T02:06:56Z
dc.date.available2023-09-04T01:40:48Z
dc.date.issued2021-06-18
dc.date.updated2023-07-17T02:43:33Z
dc.description(c) The Author/sen_US
dc.description.abstractThe study aimed to determine factors associated with changes in bone mineral density (BMD) and bone resorption markers over two years in black postmenopausal women living with human immunodeficiency virus (HIV) on antiretroviral therapy (ART). Women (n = 120) aged > 45 years were recruited from Potchefstroom, South Africa. Total lumbar spine and left femoral neck (LFN) BMD were measured with dual energy X-ray absorptiometry. Fasting serum C-Telopeptide of Type I collagen (CTx), vitamin D and parathyroid hormone were measured. Vitamin D insufficiency levels increased from 23% at baseline to 39% at follow up. In mixed linear models serum CTx showed no change from baseline to end (p = 0.363, effect size = 0.09). Total and LFN BMD increased significantly over two years, but effect sizes were small. No significant change in spine BMD over time was detected (p = 0.19, effect size = 0.02). Age was significantly positively associated with CTx over time, and negatively with total and LFN BMD. Physical activity (PA) was positively associated with LFN BMD (p = 0.008). Despite a decrease in serum vitamin D, BMD and CTx showed small or no changes over 2 years. Future studies should investigate PA interventions to maintain BMD in women living with HIV.
dc.description.confidentialfalse
dc.edition.editionJune 2021
dc.format.extent2090-
dc.identifierARTN 2090
dc.identifiernu13062090
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/34207469
dc.identifier.citationEllis C, Kruger HS, Viljoen M, Dave JA, Kruger MC. (2021). Factors Associated with Bone Mineral Density and Bone Resorption Markers in Postmenopausal HIV-Infected Women on Antiretroviral Therapy: A Prospective Cohort Study.. Nutrients. 13. 6. (pp. 2090-).
dc.identifier.doi10.3390/nu13062090
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10179/19881
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/13/6/2090
dc.relation.isPartOfNutrients
dc.rightsCC BYen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHIV
dc.subjectblack
dc.subjectbone mineral density
dc.subjectcalcium
dc.subjectpostmenopausal
dc.subjectAbsorptiometry, Photon
dc.subjectAntirheumatic Agents
dc.subjectBone Density
dc.subjectBone Resorption
dc.subjectCollagen Type I
dc.subjectEating
dc.subjectFemale
dc.subjectFemur Neck
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectLumbar Vertebrae
dc.subjectMiddle Aged
dc.subjectOsteoporosis, Postmenopausal
dc.subjectParathyroid Hormone
dc.subjectPostmenopause
dc.subjectProspective Studies
dc.subjectSouth Africa
dc.subjectVitamin D
dc.titleFactors Associated with Bone Mineral Density and Bone Resorption Markers in Postmenopausal HIV-Infected Women on Antiretroviral Therapy: A Prospective Cohort Study
dc.typeJournal article
pubs.elements-id446920
pubs.organisational-groupOther
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