IKVAV-Containing Cell Membrane Penetrating Peptide Treatment Induces Changes in Cellular Morphology after Spinal Cord Injury

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dc.citation.issue11
dc.citation.volume10
dc.contributor.authorBaltzer WI
dc.contributor.authorkazemi S
dc.contributor.authorMansouri H
dc.contributor.authorMata J
dc.contributor.authorSchilke K
dc.date.available2016-08-17
dc.date.issued2016-08-17
dc.description.abstractA cell membrane spanning peptide was used to increase the concentration of the IKVAV motif within damaged mouse spinal cord tissue. This peptide was injected directly to the lesion 24 hours after spinal cord compression injury. Because the membrane-spanning portion of the peptide adheres to tissue upon injection with a long half-life we hypothesized that the bioactive IKVAV sequence will provide a sustained regenerative signal at the sight of injury. Five different groups of mice were used and cellular morphology observations were undertaken using light and electron microscopy. Three surgical control groups: IKVAV, peptide and mannitol; one surgical treatment group: IKVAV-peptide; and one non-surgical control group: normal, were used in this experiment. In this study, treatment with IKVAV-peptide after SCI resulted in an increased number of protoplasmic astrocytes, large active motor neurons, and regeneration of muscle bundles followed by behavioral improvement. In this paper, we describe the cellular differences between all groups.
dc.description.confidentialfalse
dc.identifierhttp://dx.doi.org/10.5539/mas.v10n11p149
dc.identifierhttp://dx.doi.org/10.5539/mas.v10n11p149
dc.identifier.citationModern Applied Science, 2016, 10 (11)
dc.identifier.doi10.5539/mas.v10n11p149
dc.identifier.elements-id386771
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1913-1844
dc.languageEnglish
dc.publisherCanadian Center of Science and Education
dc.publisher.urihttp://dx.doi.org/10.5539/mas.v10n11p149
dc.relation.isPartOfModern Applied Science
dc.relation.urihttp://ccsenet.org/journal/index.php/mas/article/view/62364
dc.subjectIKVAV+peptide, neurons, protoplasmic astrocytes, muscle bundles, light micrographs, electron micrographs
dc.titleIKVAV-Containing Cell Membrane Penetrating Peptide Treatment Induces Changes in Cellular Morphology after Spinal Cord Injury
dc.typeJournal article
pubs.notesNot known
pubs.organisational-group/Massey University
pubs.organisational-group/Massey University/College of Sciences
pubs.organisational-group/Massey University/College of Sciences/Institute of Vet, Animal & Biomed Science
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