Baseline audiological profiling of South African females with cervical cancer: an important attribute for assessing cisplatin-associated ototoxicity

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dc.citation.issue1
dc.citation.volume21
dc.contributor.authorPaken J
dc.contributor.authorGovender CD
dc.contributor.authorPillay M
dc.contributor.authorAyele BT
dc.contributor.authorSewram V
dc.coverage.spatialEngland
dc.date.accessioned2023-09-15T03:22:16Z
dc.date.accessioned2023-09-21T22:14:57Z
dc.date.available2021-04-20
dc.date.available2023-09-15T03:22:16Z
dc.date.available2023-09-21T22:14:57Z
dc.date.issued2021
dc.date.updated2023-09-05T02:21:10Z
dc.description(c) The Author/s 2021en_US
dc.description.abstractBackground Cisplatin is a popular antineoplastic agent used to treat cervical cancer in women from low and middle-income countries. Cisplatin treatment is associated with ototoxicity, often resulting in hearing loss. In light of this, it is crucial to conduct baseline audiological assessments prior to treatment initiation in order to evaluate the extent of cisplatin-associated-ototoxicity. Additionally, the identification of inherent risk factors and hearing patterns in specific patient cohorts is needed, especially in South Africa, a middle-income country characterized by the quadruple burden of disease (Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Diabetes and Hypertension). Methods This study aimed to describe a profile of risk factors and hearing in a cohort of females with cervical cancer before cisplatin treatment commenced. A descriptive study design that included 82 cervical cancer patients, who underwent audiological evaluation prescribed for ototoxicity monitoring was conducted. Results All participants (n = 82) presented with risk factors (diabetes, hypertension, HIV, and antiretroviral therapy) for cisplatin ototoxicity and/or pre-existing sensorineural hearing loss. High-frequency tinnitus was the most common otological symptom experienced by 25 (31%) participants. Fifty-nine (72%) participants presented with normal hearing, twenty-two (27%) with a sensorineural hearing loss, and 36% were diagnosed with mild hearing loss. Abnormal Distortion Product Otoacoustic Emissions (DPOAE) findings were obtained bilaterally in two participants (2.4%), in the right ear only of another two (2.4%) participants and the left ear of three participants (3.7%). Most participants (94%) had excellent word recognition scores, demonstrating an excellent ability to recognize words within normal conversational levels under optimal listening conditions. Age was significantly associated with hearing loss at all thresholds. Among the co-morbidities, an HIV positive status significantly triggered hearing loss, especially at higher frequencies. Conclusion This study demonstrated that South African females with cervical cancer present with various co-morbidities, which may predispose them to develop cisplatin-associated -ototoxic hearing loss. Identification of these co-morbidities and hearing loss is essential for the accurate monitoring of cisplatin toxicities. Appropriate management of these patients is pivotal to reduce the adverse effects that hearing impairment can have on an individual’s quality of life and to facilitate informed decision-making regarding the commencement of cisplatin chemotherapy.
dc.format.extent164-
dc.identifierARTN 164
dc.identifier10.1186/s12905-021-01313-5
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33879158
dc.identifier.citationPaken J, Govender CD, Pillay M, Ayele BT, Sewram V. (2021). Baseline audiological profiling of South African females with cervical cancer: an important attribute for assessing cisplatin-associated ototoxicity.. BMC Womens Health. 21. 1. (pp. 164-).
dc.identifier.doi10.1186/s12905-021-01313-5
dc.identifier.eissn1472-6874
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1472-6874
dc.identifier.urihttp://hdl.handle.net/10179/20103
dc.languageeng
dc.publisherBioMed Central Ltd
dc.relation.isPartOfBMC Womens Health
dc.rightsCC BY 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCervical cancer
dc.subjectCisplatin ototoxicity
dc.subjectDiabetes
dc.subjectHIV
dc.subjectHearing
dc.subjectHypertension
dc.subjectOtotoxic medication
dc.subjectRisk factors
dc.subjectAntineoplastic Agents
dc.subjectCisplatin
dc.subjectFemale
dc.subjectHumans
dc.subjectOtoacoustic Emissions, Spontaneous
dc.subjectOtotoxicity
dc.subjectQuality of Life
dc.subjectSouth Africa
dc.subjectUterine Cervical Neoplasms
dc.titleBaseline audiological profiling of South African females with cervical cancer: an important attribute for assessing cisplatin-associated ototoxicity
dc.typeJournal article
pubs.elements-id445818
pubs.organisational-groupOther
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