Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation
dc.citation.volume | 9 | |
dc.contributor.author | Daniels NJ | |
dc.contributor.author | Hyde E | |
dc.contributor.author | Ghosh S | |
dc.contributor.author | Seo K | |
dc.contributor.author | Price KM | |
dc.contributor.author | Hoshino K | |
dc.contributor.author | Kaisho T | |
dc.contributor.author | Okada T | |
dc.contributor.author | Ronchese F | |
dc.date.available | 2016-01 | |
dc.date.available | 2015-05-19 | |
dc.date.issued | 2016-01 | |
dc.description.abstract | Allergic airway inflammation is driven by the recognition of inhaled allergen by T helper type 2 (Th2) cells in the airway and lung. Allergen-specific cytotoxic T lymphocytes (CTLs) can strongly reduce airway inflammation, however, the mechanism of their inhibitory activity is not fully defined. We used mouse models to show that allergen-specific CTLs reduced early cytokine production by Th2 cells in lung, and their subsequent accumulation and production of interleukin (IL)-4 and IL-13. In addition, treatment with specific CTLs also increased the proportion of caspase+ dendritic cells (DCs) in mediastinal lymph node (MLN), and decreased the numbers of CD103+ and CD11b+ DCs in the lung. This decrease required expression of the cytotoxic mediator perforin in CTLs and of the appropriate MHC-antigen ligand on DCs, suggesting that direct CTL-DC contact was necessary. Lastly, lung imaging experiments revealed that in airway-challenged mice XCR1-GFP+ DCs, corresponding to the CD103+ DC subset, and XCR1-GFP− CD11c+ cells, which include CD11b+ DCs and alveolar macrophages, both clustered in the areas surrounding the small airways and were closely associated with allergen-specific CTLs. Thus, allergen-specific CTLs reduce allergic airway inflammation by depleting CD103+ and CD11b+ DC populations in the lung, and may constitute a mechanism through which allergic immune responses are regulated. | |
dc.description.confidential | FALSE | |
dc.format.extent | 229 - 239 (11) | |
dc.identifier.citation | Mucosal Immunology, 2016, 9 pp. 229 - 239 (11) | |
dc.identifier.doi | 10.1038/mi.2015.55 | |
dc.identifier.elements-id | 280296 | |
dc.identifier.harvested | Massey_Dark | |
dc.identifier.issn | 1935-3456 | |
dc.identifier.uri | https://hdl.handle.net/10179/9811 | |
dc.publisher | Nature Publishing Group | |
dc.relation.isPartOf | Mucosal Immunology | |
dc.relation.replaces | http://hdl.handle.net/123456789/2969 | |
dc.relation.replaces | 123456789/2969 | |
dc.relation.uri | http://www.nature.com/mi/journal/v9/n1/full/mi201555a.html | |
dc.subject | Immunology | |
dc.subject | Dendritic cells | |
dc.subject | Flow cytometry | |
dc.subject | RNA | |
dc.subject | Cytotoxicity | |
dc.subject | CTL | |
dc.subject | T lymphocytes | |
dc.subject | CD103+ | |
dc.subject | CD11b+ | |
dc.subject | antigen | |
dc.subject | antibody | |
dc.subject.anzsrc | 06 Biological Sciences | |
dc.subject.anzsrc | 11 Medical and Health Sciences | |
dc.title | Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation | |
dc.type | Journal article | |
pubs.notes | Not known | |
pubs.organisational-group | /Massey University | |
pubs.organisational-group | /Massey University/College of Sciences | |
pubs.organisational-group | /Massey University/College of Sciences/School of Veterinary Science |