Multiple QTL underlie milk phenotypes at the CSF2RB locus.

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dc.citation.issue1
dc.citation.volume51
dc.contributor.authorLopdell TJ
dc.contributor.authorTiplady K
dc.contributor.authorCouldrey C
dc.contributor.authorJohnson TJJ
dc.contributor.authorKeehan M
dc.contributor.authorDavis SR
dc.contributor.authorHarris BL
dc.contributor.authorSpelman RJ
dc.contributor.authorSnell RG
dc.contributor.authorLittlejohn MD
dc.coverage.spatialFrance
dc.date.accessioned2024-11-04T00:24:00Z
dc.date.available2024-11-04T00:24:00Z
dc.date.issued2019-01-24
dc.description.abstractBackground Over many years, artificial selection has substantially improved milk production by cows. However, the genes that underlie milk production quantitative trait loci (QTL) remain relatively poorly characterised. Here, we investigate a previously reported QTL located at the CSF2RB locus on chromosome 5, for several milk production phenotypes, to better understand its underlying genetic and molecular causes. Results Using a population of 29,350 taurine dairy cows, we conducted association analyses for milk yield and composition traits, and identified highly significant QTL for milk yield, milk fat concentration, and milk protein concentration. Strikingly, protein concentration and milk yield appear to show co-located yet genetically distinct QTL. To attempt to understand the molecular mechanisms that might be mediating these effects, gene expression data were used to investigate eQTL for 11 genes in the broader interval. This analysis highlighted genetic impacts on CSF2RB and NCF4 expression that share similar association signatures to those observed for lactation QTL, strongly implicating one or both of these genes as responsible for these effects. Using the same gene expression dataset representing 357 lactating cows, we also identified 38 novel RNA editing sites in the 3′ UTR of CSF2RB transcripts. The extent to which two of these sites were edited also appears to be genetically co-regulated with lactation QTL, highlighting a further layer of regulatory complexity that involves the CSF2RB gene. Conclusions This locus presents a diversity of molecular and lactation QTL, likely representing multiple overlapping effects that, at a minimum, highlight the CSF2RB gene as having a causal role in these processes.
dc.description.confidentialfalse
dc.format.pagination3-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30678637
dc.identifier.citationLopdell TJ, Tiplady K, Couldrey C, Johnson TJJ, Keehan M, Davis SR, Harris BL, Spelman RJ, Snell RG, Littlejohn MD. (2019). Multiple QTL underlie milk phenotypes at the CSF2RB locus.. Genet Sel Evol. 51. 1. (pp. 3-).
dc.identifier.doi10.1186/s12711-019-0446-x
dc.identifier.eissn1297-9686
dc.identifier.elements-typejournal-article
dc.identifier.issn0999-193X
dc.identifier.numberARTN 3
dc.identifier.pii10.1186/s12711-019-0446-x
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71899
dc.languageeng
dc.publisherBioMed Central Ltd
dc.publisher.urihttps://gsejournal.biomedcentral.com/articles/10.1186/s12711-019-0446-x
dc.relation.isPartOfGenet Sel Evol
dc.rights(c) 2019 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject3' Untranslated Regions
dc.subjectAnimals
dc.subjectCattle
dc.subjectCytokine Receptor Common beta Subunit
dc.subjectFemale
dc.subjectLactation
dc.subjectMale
dc.subjectMilk
dc.subjectPhenotype
dc.subjectPhosphoproteins
dc.subjectQuantitative Trait Loci
dc.titleMultiple QTL underlie milk phenotypes at the CSF2RB locus.
dc.typeJournal article
pubs.elements-id445224
pubs.organisational-groupCollege of Health
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