Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease

Simple item page
dc.citation.issue11
dc.citation.volume13
dc.contributor.authorJayatunga DPW
dc.contributor.authorHone E
dc.contributor.authorKhaira H
dc.contributor.authorLunelli T
dc.contributor.authorSingh H
dc.contributor.authorGuillemin GJ
dc.contributor.authorFernando B
dc.contributor.authorGarg ML
dc.contributor.authorVerdile G
dc.contributor.authorMartins RN
dc.contributor.editorGiannakopoulos P
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-05-14T21:31:20Z
dc.date.available2024-05-14T21:31:20Z
dc.date.issued2021-11
dc.description.abstractMitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bioactive food components, known as nutraceuticals, may serve as such agents to combat AD. Urolithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-atherogenic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underlying mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. Moreover, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.
dc.description.confidentialfalse
dc.edition.editionNovember 2021
dc.format.pagination3744-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34836000
dc.identifier.citationJayatunga DPW, Hone E, Khaira H, Lunelli T, Singh H, Guillemin GJ, Fernando B, Garg ML, Verdile G, Martins RN. (2021). Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease.. Nutrients. 13. 11. (pp. 3744-).
dc.identifier.doi10.3390/nu13113744
dc.identifier.eissn2072-6643
dc.identifier.elements-typejournal-article
dc.identifier.issn2072-6643
dc.identifier.numberARTN 3744
dc.identifier.piinu13113744
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/69557
dc.languageeng
dc.publisherMDPI (Basel, Switzerland)
dc.publisher.urihttps://www.mdpi.com/2072-6643/13/11/3744
dc.relation.isPartOfNutrients
dc.rights(c) 2021 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectmitophagy
dc.subjectneuroprotection
dc.subjectnutraceuticals
dc.subjectpomegranate
dc.subjecturolithin A
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectCoumarins
dc.subjectHumans
dc.subjectLongevity
dc.subjectMicrobiota
dc.subjectMitophagy
dc.subjectPolyphenols
dc.titleTherapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
dc.typeJournal article
pubs.elements-id449338
pubs.organisational-groupOther
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