Inflatable Penile Prostheses Implantation: Does Antibiotic Exposure Matter?

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dc.citation.issue3
dc.citation.volume6
dc.contributor.authorChanyi RM
dc.contributor.authorAlzubaidi R
dc.contributor.authorLeung EJY
dc.contributor.authorWilcox HB
dc.contributor.authorBrock GB
dc.contributor.authorBurton JP
dc.coverage.spatialEngland
dc.date.accessioned2024-07-31T02:46:47Z
dc.date.available2024-07-31T02:46:47Z
dc.date.issued2018-09-01
dc.description.abstractBACKGROUND: Inflatable penile prosthetic (IPP) infections are unusual but carry high patient morbidity and healthcare costs. AIM: To increase the bactericidal effect of IPP tubing material to prevent future bacterial infections and to determine whether this effect is time-dependent. METHODS: A modified disk diffusion assay was developed to measure the zones of inhibition against Escherichia coli, Proteus mirabilis, Staphylococcus aureus, and Staphylococcus epidermidis when tubing was immersed in gentamycin, ampicillin, tetracycline, kanamycin, erythromycin, or ciprofloxacin. To further assess the efficacy of this approach, IPP tubing was exposed to ampicillin or ciprofloxacin for 30 seconds, 2 minutes, 10 minutes, or 60 minutes. OUTCOMES: Bacterial zones of inhibition against IPP tubing material exposed to various treatments. RESULTS: IPP tubing was more effective against Gram-positive bacteria (S aureus and S epidermidis) then Gram-negative bacteria (E coli and P mirabilis). Immersing IPP tubing material in ampicillin or ciprofloxacin increased bactericidal effect of tubing material against Gram-positive and Gram-negative bacteria, respectively. The observed inhibitory effect was time dependent. CLINICAL TRANSLATION: Exposing IPP to a specific antimicrobial directly before implantation increases the bactericidal properties of the material, potentially decreasing the likelihood of infection. STRENGTHS & LIMITATIONS: This study is limited in that it is in vitro experimentation observing the effect of a single strain of each bacterium. Although the strains used were clinically relevant, further analysis is required to determine whether these results were strain specific. CONCLUSION: Immersing IPP material into an antibiotic solution, such as ampicillin or ciprofloxacin, increases the bactericidal properties and may aid in the prevention of infection.
dc.description.confidentialfalse
dc.edition.editionSeptember 2018
dc.format.pagination248-254
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30017599
dc.identifier.citationChanyi RM, Alzubaidi R, Leung EJY, Wilcox HB, Brock GB, Burton JP. (2018). Inflatable Penile Prostheses Implantation: Does Antibiotic Exposure Matter?. Sex Med. 6. 3. (pp. 248-254).
dc.identifier.doi10.1016/j.esxm.2018.05.004
dc.identifier.eissn2050-1161
dc.identifier.elements-typejournal-article
dc.identifier.issn2050-1161
dc.identifier.piiS2050-1161(18)30054-0
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71168
dc.languageeng
dc.publisherOxford University Press
dc.publisher.urihttps://academic.oup.com/smoa/article/6/3/248/6956430
dc.relation.isPartOfSex Med
dc.rights(c) 2018 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntibiotic Use
dc.subjectIPP
dc.subjectInfection
dc.subjectInfection Prevention
dc.subjectInflatable Penile Prosthesis
dc.titleInflatable Penile Prostheses Implantation: Does Antibiotic Exposure Matter?
dc.typeJournal article
pubs.elements-id454250
pubs.organisational-groupOther
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