Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review

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dc.citation.issue8
dc.citation.volume61
dc.contributor.authorNanavati K
dc.contributor.authorRutherfurd-Markwick K
dc.contributor.authorLee SJ
dc.contributor.authorBishop NC
dc.contributor.authorAli A
dc.coverage.spatialGermany
dc.date.accessioned2023-08-10T21:50:41Z
dc.date.accessioned2023-09-04T01:41:02Z
dc.date.available2022-07-13
dc.date.available2023-08-10T21:50:41Z
dc.date.available2023-09-04T01:41:02Z
dc.date.issued2022-07-13
dc.date.updated2023-08-09T03:05:47Z
dc.description.abstractCurcumin, a natural polyphenol extracted from turmeric, is a potent antioxidant and anti-inflammatory agent. In the past few decades, curcumin's ability to impact chronic inflammatory conditions such as metabolic syndrome, arthritis, and cancer has been widely researched, along with growing interest in understanding its role in exercise-induced muscle damage (EIMD). EIMD impacts individuals differently depending on the type (resistance exercise, high-intensity interval training, and running), intensity, and duration of the exercise. Exercise disrupts the muscles' ultrastructure, raises inflammatory cytokine levels, and can cause swelling in the affected limb, a reduction in range of motion (ROM), and a reduction in muscular force-producing capacity. This review focuses on the metabolism, pharmacokinetics of various brands of curcumin supplements, and the effect of curcumin supplementation on EIMD regarding muscle soreness, activity of creatine kinase (CK), and production of inflammatory markers. Curcumin supplementation in the dose range of 90-5000 mg/day can decrease the subjective perception of muscle pain intensity, increase antioxidant capacity, and reduce CK activity, which reduces muscle damage when consumed close to exercise. Consumption of curcumin also improves muscle performance and has an anti-inflammatory effect, downregulating the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. Curcumin may also improve oxidative capacity without hampering training adaptations in untrained and recreationally active individuals. The optimal curcumin dose to ameliorate EIMD is challenging to assess as its effect depends on the curcumin concentration in the supplement and its bioavailability.
dc.format.extent3835-3855
dc.identifier10.1007/s00394-022-02943-7
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/35831667
dc.identifier.citationNanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. (2022). Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review.. Eur J Nutr. 61. 8. (pp. 3835-3855).
dc.identifier.doi10.1007/s00394-022-02943-7
dc.identifier.eissn1436-6215
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn1436-6207
dc.identifier.urihttp://hdl.handle.net/10179/19912
dc.languageeng
dc.publisherSpringer-Verlag GmbH Germany, part of Springer Nature
dc.relation.isPartOfEur J Nutr
dc.rights© The Author(s) 2022 CC BY 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAntioxidant
dc.subjectCurcumin
dc.subjectInflammation
dc.subjectMuscle soreness
dc.subjectOxidative stress
dc.subjectPharmacokinetics
dc.subjectHumans
dc.subjectAnti-Inflammatory Agents
dc.subjectAntioxidants
dc.subjectCreatine Kinase
dc.subjectCurcumin
dc.subjectCytokines
dc.subjectDietary Supplements
dc.subjectInterleukin-6
dc.subjectInterleukin-8
dc.subjectMuscle, Skeletal
dc.subjectMyalgia
dc.subjectPolyphenols
dc.subjectTumor Necrosis Factor-alpha
dc.subjectExercise
dc.titleEffect of curcumin supplementation on exercise-induced muscle damage: a narrative review
dc.typeJournal article
pubs.elements-id454743
pubs.organisational-groupOther
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