Studies on the occurrence of anthelmintic resistance in goat parasites in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Studies in Parasitology at Massey University, Palmerston North, New Zealand

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dc.contributor.authorKamaludeen, Juriah
dc.date.accessioned2010-09-16T02:04:10Z
dc.date.availableNO_RESTRICTIONen_US
dc.date.available2010-09-16T02:04:10Z
dc.date.issued2010
dc.description.abstractTwo studies were conducted to investigate anthelmintic resistance in goat parasites in New Zealand. In Study 1 parasites from goats on a farm with a long history of problems with anthelmintic efficacy were used to infect sheep for a controlled slaughter study. Nineteen lambs were acquired, effectively drenched and housed. Each was infected with a mixture of larvae comprising Haemonchus contortus, Teladorsagia circumcincta, Trichostrongylus colubriformis and Oesophagostomum venulosum. After 28 days lambs were restrictively randomised into 3 groups based on faecal egg counts. Group 1 was left untreated (n=6), Group 2 (n=6) was given a single dose of abamectin (0.2mg/kg) + levamisole HCL (8mg/kg) + oxfendazole (4.5mg/kg) (“Matrix Oral Drench for Sheep”®, Ancare, New Zealand) and Group 3 (n=7) was treated at twice the dose rate of Group 2. Fourteen days after treatment all animals were killed for total worm counts. The mean burdens of T. circumcincta in Group 1 was 337, in Group 2 was 68 (efficacy 80%) and in Group 3 was 10 (efficacy 97%). The mean burdens of T. colubriformis in Group 1 was 375, in Group 2 was 220 (efficacy 41%) and in Group 3 was 81 (efficacy 78%). Although the worm burdens in these lambs were low, all animals were infected with each of these two species except for T. circumcincta in Group 3 where only 3 lambs were infected. Efficacy against other species was 100%. These results clearly indicate that a single dose of a combination drench was ineffective against two species and even when a double dose was used the efficacy against T. colubriformis was only 78%. In Study 2 a survey of drench efficacy was conducted on 17 goat farms using the DrenchRite® larval development assay. Evidence of concurrent resistance to benzimidazoles, levamisole and ivermectin was detected in T. colubriformis and T. circumcincta on 11/17 and 3/14 respectively. Only 5 of 14 farms had previously undertaken some form of testing for drench resistance prior to this survey. Evidence from these two studies suggests that severe anthelmintic resistance is common on goat farms in New Zealanden_US
dc.identifier.urihttp://hdl.handle.net/10179/1652
dc.language.isoenen_US
dc.publisherMassey Universityen_US
dc.rightsThe Authoren_US
dc.subjectGoat parasitesen_US
dc.subjectDrench resistanceen_US
dc.subjectHaemonchus contortusen_US
dc.subjectTeladorsagia circumcinctaen_US
dc.subjectTrichostrongylus colubriformisen_US
dc.subjectOesophagostomum venulosumen_US
dc.subject.otherFields of Research::300000 Agricultural, Veterinary and Environmental Sciences::300500 Veterinary Medicine::300508 Parasitologyen_US
dc.titleStudies on the occurrence of anthelmintic resistance in goat parasites in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Studies in Parasitology at Massey University, Palmerston North, New Zealanden_US
dc.typeThesisen_US
massey.contributor.authorKamaludeen, Juriah
thesis.degree.disciplineParasitologyen_US
thesis.degree.grantorMassey Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Veterinary Studies (M.V.S.)en_US
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