A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial.

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dc.citation.issue1
dc.citation.volume20
dc.contributor.authorZülke AE
dc.contributor.authorPabst A
dc.contributor.authorLuppa M
dc.contributor.authorRoehr S
dc.contributor.authorSeidling H
dc.contributor.authorOey A
dc.contributor.authorCardona MI
dc.contributor.authorBlotenberg I
dc.contributor.authorBauer A
dc.contributor.authorWeise S
dc.contributor.authorZöllinger I
dc.contributor.authorSanftenberg L
dc.contributor.authorBrettschneider C
dc.contributor.authorDöhring J
dc.contributor.authorLunden L
dc.contributor.authorCzock D
dc.contributor.authorHaefeli WE
dc.contributor.authorWiese B
dc.contributor.authorHoffmann W
dc.contributor.authorFrese T
dc.contributor.authorGensichen J
dc.contributor.authorKönig H-H
dc.contributor.authorKaduszkiewicz H
dc.contributor.authorThyrian JR
dc.contributor.authorRiedel-Heller SG
dc.coverage.spatialUnited States
dc.date.accessioned2024-06-27T02:30:29Z
dc.date.available2024-06-27T02:30:29Z
dc.date.issued2024-01-01
dc.description.abstractINTRODUCTION: We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia in Germany in a cluster-randomized trial. METHODS: Individuals with a Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score ≥ 9 aged 60 to 77 years were recruited. After randomization of their general practitioner (GP), patients received a multidomain intervention (including optimization of nutrition and medication, and physical, social, and cognitive activity) or general health advice and GP treatment as usual over 24 months. Primary outcome was global cognitive performance (composite z score, based on domain-specific neuropsychological tests). RESULTS: Of 1030 participants at baseline, n = 819 completed the 24-month follow-up assessment. No differences regarding global cognitive performance (average marginal effect = 0.010, 95% confidence interval: -0.113, 0.133) were found between groups at follow-up. Perceived restrictions in intervention conduct by the COVID-19 pandemic did not impact intervention effectiveness. DISCUSSION: The intervention did not improve global cognitive performance. HIGHLIGHTS: Overall, no intervention effects on global cognitive performance were detected. The multidomain intervention improved health-related quality of life in the total sample. In women, the multidomain intervention reduced depressive symptoms. The intervention was completed during the COVID-19 pandemic.
dc.description.confidentialfalse
dc.edition.editionJanuary 2024
dc.format.pagination615-628
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37768074
dc.identifier.citationZülke AE, Pabst A, Luppa M, Roehr S, Seidling H, Oey A, Cardona MI, Blotenberg I, Bauer A, Weise S, Zöllinger I, Sanftenberg L, Brettschneider C, Döhring J, Lunden L, Czock D, Haefeli WE, Wiese B, Hoffmann W, Frese T, Gensichen J, König H-H, Kaduszkiewicz H, Thyrian JR, Riedel-Heller SG. (2024). A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial.. Alzheimers Dement. 20. 1. (pp. 615-628).
dc.identifier.doi10.1002/alz.13486
dc.identifier.eissn1552-5279
dc.identifier.elements-typejournal-article
dc.identifier.issn1552-5260
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70032
dc.languageeng
dc.publisherJohn Wiley and Sons, Inc.
dc.publisher.urihttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13486
dc.relation.isPartOfAlzheimers Dement
dc.rights(c) 2023 The Author/s
dc.rightsCC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectcognitive function
dc.subjectdementia
dc.subjectlifestyle
dc.subjectprevention
dc.subjectrandomized controlled trial
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectCognitive Dysfunction
dc.subjectCOVID-19
dc.subjectDementia
dc.subjectPandemics
dc.subjectQuality of Life
dc.subjectRisk Factors
dc.titleA multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial.
dc.typeJournal article
pubs.elements-id480852
pubs.organisational-groupOther
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