Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review

Wagner J; Rusconi E

Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review

dc.citation.issue	1
dc.citation.volume	228
dc.contributor.author	Wagner J
dc.contributor.author	Rusconi E
dc.coverage.spatial	Germany
dc.date.accessioned	2024-12-04T02:08:44Z
dc.date.available	2024-12-04T02:08:44Z
dc.date.issued	2023-01-01
dc.description.abstract	Transcranial magnetic stimulation (TMS) is a non-invasive technique that can transiently interfere with local cortical functioning, thus enabling inferences of causal left AG involvement in higher functions from experimentation with healthy participants. Here, we examine 35 studies that measure behavioural outcomes soon after or during targeting TMS to the left AG, by design and as documented by individual magnetic resonance images, in healthy adult participants. The reviewed evidence suggests a specific causal involvement of the left AG in a wide range of tasks involving language, memory, number processing, visuospatial attention, body awareness and motor planning functions. These core findings are particularly valuable to inform theoretical models of the left AG role(s) in higher functions, due to the anatomical specificity afforded by the selected studies and the complementarity of TMS to different methods of investigation. In particular, the variety of the operations within and between functions in which the left AG appears to be causally involved poses a formidable challenge to any attempts to identify a single computational process subserved by the left AG (as opposed to just outlining a broad type of functional contribution) that could apply across thematic areas. We conclude by highlighting directions for improvement in future experimentation with TMS, in order to strengthen the available evidence, while taking into account the anatomical heterogeneity of this brain region.
dc.description.confidential	false
dc.edition.edition	2023
dc.format.pagination	169-196
dc.identifier.author-url	https://www.ncbi.nlm.nih.gov/pubmed/36260126
dc.identifier.citation	Wagner J, Rusconi E. (2023). Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review.. Brain Struct Funct. 228. 1. (pp. 169-196).
dc.identifier.doi	10.1007/s00429-022-02576-w
dc.identifier.eissn	1863-2661
dc.identifier.elements-type	journal-article
dc.identifier.issn	1863-2653
dc.identifier.pii	10.1007/s00429-022-02576-w
dc.identifier.uri	https://mro.massey.ac.nz/handle/10179/72189
dc.language	eng
dc.publisher	Springer Nature
dc.publisher.uri	https://link.springer.com/article/10.1007/s00429-022-02576-w
dc.relation.isPartOf	Brain Struct Funct
dc.rights	(c) The author/s	en
dc.rights.license	CC BY	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Angular gyrus
dc.subject	Cognition
dc.subject	Left hemisphere
dc.subject	Theta burst stimulation
dc.subject	Transcranial magnetic stimulation
dc.subject	Adult
dc.subject	Humans
dc.subject	Transcranial Magnetic Stimulation
dc.subject	Brain Mapping
dc.subject	Parietal Lobe
dc.subject	Language
dc.subject	Attention
dc.subject	Magnetic Resonance Imaging
dc.title	Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
dc.type	Journal article
pubs.elements-id	480144
pubs.organisational-group	Other