The effect of a 2 week ketogenic diet, versus a carbohydrate-based diet, on cognitive performance, mood and subjective sleepiness during 36 h of extended wakefulness in military personnel: An exploratory study

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dc.citation.issue4
dc.citation.volume32
dc.contributor.authorHenderson LR
dc.contributor.authorvan den Berg M
dc.contributor.authorShaw D
dc.coverage.spatialEngland
dc.date.accessioned2023-08-10T19:51:47Z
dc.date.accessioned2023-09-04T01:41:06Z
dc.date.available2023-02-03
dc.date.available2023-08-10T19:51:47Z
dc.date.available2023-09-04T01:41:06Z
dc.date.issued2023-08
dc.date.updated2023-08-10T03:21:52Z
dc.description.abstractExtended wakefulness, or sleep deprivation, impairs cognitive performance and brain glucose metabolism. A ketogenic diet (KD) provides an alternative fuel source, ketone bodies, that could elicit a metabolic benefit during sleep deprivation. A randomised, cross-over trial was conducted with seven male military personnel. Participants ingested an iso-energetic ketogenic diet or carbohydrate-based diet for 14 days, immediately followed by 36 h of extended wakefulness and separated by a 12 day washout. Cognitive performance, mood, subjective sleepiness, capillary blood glucose, and D-β-hydroxybutyrate concentrations were measured every 2 h during extended wakefulness. Linear mixed models were used to analyse data. D-β-hydroxybutyrate was higher (p < 0.001) and glucose was lower (p < 0.01) on the KD compared with the carbohydrate-based diet. The KD improved psychomotor vigilance task performance (number of lapses, mean reciprocal response time, mean fastest 10% response time (RT), and mean slowest 10% RT; all p < 0.05), running memory continuous performance test performance (RT and number of correct responses per minute; both p < 0.01), and vigour, fatigue, and sleepiness (all, p ≤ 0.001) compared with the carbohydrate-based diet. In conclusion, a KD demonstrated beneficial effects on cognitive performance, mood, and sleepiness during 36 h of extended wakefulness compared with a carbohydrate-based diet.
dc.description.confidentialfalse
dc.format.extente13832-
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/36734405
dc.identifier.citationHenderson LR, van den Berg M, Shaw DM. (2023). The effect of a 2 week ketogenic diet, versus a carbohydrate-based diet, on cognitive performance, mood and subjective sleepiness during 36 h of extended wakefulness in military personnel: An exploratory study.. J Sleep Res. 32. 4. (pp. e13832-).
dc.identifier.doi10.1111/jsr.13832
dc.identifier.eissn1365-2869
dc.identifier.elements-typejournal-article
dc.identifier.harvestedMassey_Dark
dc.identifier.issn0962-1105
dc.identifier.urihttp://hdl.handle.net/10179/19922
dc.languageeng
dc.publisherJohn Wiley & Sons Ltd on behalf of European Sleep Research Society
dc.relation.isPartOfJ Sleep Res
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectfatigue management
dc.subjectketo-adaptation
dc.subjectketosis
dc.subjectpsychomotor vigilance task
dc.subjectrandomised controlled trial
dc.subjectsleep deprivation
dc.subjectHumans
dc.subjectMale
dc.subjectWakefulness
dc.subjectSleep Deprivation
dc.subjectDiet, Ketogenic
dc.subjectSleepiness
dc.subjectMilitary Personnel
dc.subject3-Hydroxybutyric Acid
dc.subjectPsychomotor Performance
dc.subjectCognition
dc.subjectCarbohydrates
dc.subjectSleep
dc.titleThe effect of a 2 week ketogenic diet, versus a carbohydrate-based diet, on cognitive performance, mood and subjective sleepiness during 36 h of extended wakefulness in military personnel: An exploratory study
dc.typeJournal article
pubs.elements-id459418
pubs.organisational-groupOther
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