Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.

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dc.citation.issue3
dc.citation.volume129
dc.contributor.authorDimou N
dc.contributor.authorKim AE
dc.contributor.authorFlanagan O
dc.contributor.authorMurphy N
dc.contributor.authorDiez-Obrero V
dc.contributor.authorShcherbina A
dc.contributor.authorAglago EK
dc.contributor.authorBouras E
dc.contributor.authorCampbell PT
dc.contributor.authorCasey G
dc.contributor.authorGallinger S
dc.contributor.authorGruber SB
dc.contributor.authorJenkins MA
dc.contributor.authorLin Y
dc.contributor.authorMoreno V
dc.contributor.authorRuiz-Narvaez E
dc.contributor.authorStern MC
dc.contributor.authorTian Y
dc.contributor.authorTsilidis KK
dc.contributor.authorArndt V
dc.contributor.authorBarry EL
dc.contributor.authorBaurley JW
dc.contributor.authorBerndt SI
dc.contributor.authorBézieau S
dc.contributor.authorBien SA
dc.contributor.authorBishop DT
dc.contributor.authorBrenner H
dc.contributor.authorBudiarto A
dc.contributor.authorCarreras-Torres R
dc.contributor.authorCenggoro TW
dc.contributor.authorChan AT
dc.contributor.authorChang-Claude J
dc.contributor.authorChanock SJ
dc.contributor.authorChen X
dc.contributor.authorConti DV
dc.contributor.authorDampier CH
dc.contributor.authorDevall M
dc.contributor.authorDrew DA
dc.contributor.authorFigueiredo JC
dc.contributor.authorGiles GG
dc.contributor.authorGsur A
dc.contributor.authorHarrison TA
dc.contributor.authorHidaka A
dc.contributor.authorHoffmeister M
dc.contributor.authorHuyghe JR
dc.contributor.authorJordahl K
dc.contributor.authorKawaguchi E
dc.contributor.authorKeku TO
dc.contributor.authorLarsson SC
dc.contributor.authorLe Marchand L
dc.contributor.authorLewinger JP
dc.contributor.authorLi L
dc.contributor.authorMahesworo B
dc.contributor.authorMorrison J
dc.contributor.authorNewcomb PA
dc.contributor.authorNewton CC
dc.contributor.authorObon-Santacana M
dc.contributor.authorOse J
dc.contributor.authorPai RK
dc.contributor.authorPalmer JR
dc.contributor.authorPapadimitriou N
dc.contributor.authorPardamean B
dc.contributor.authorPeoples AR
dc.contributor.authorPharoah PDP
dc.contributor.authorPlatz EA
dc.contributor.authorPotter JD
dc.contributor.authorRennert G
dc.contributor.authorScacheri PC
dc.contributor.authorSchoen RE
dc.contributor.authorSu Y-R
dc.contributor.authorTangen CM
dc.contributor.authorThibodeau SN
dc.contributor.authorThomas DC
dc.contributor.authorUlrich CM
dc.contributor.authorUm CY
dc.contributor.authorvan Duijnhoven FJB
dc.contributor.authorVisvanathan K
dc.contributor.authorVodicka P
dc.contributor.authorVodickova L
dc.contributor.authorWhite E
dc.contributor.authorWolk A
dc.contributor.authorWoods MO
dc.contributor.authorQu C
dc.contributor.authorKundaje A
dc.contributor.authorHsu L
dc.contributor.authorGauderman WJ
dc.contributor.authorGunter MJ
dc.contributor.authorPeters U
dc.coverage.spatialEngland
dc.date.accessioned2024-08-19T21:21:20Z
dc.date.available2024-08-19T21:21:20Z
dc.date.issued2023-06-26
dc.description.abstractBACKGROUND: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. METHODS: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test). RESULTS: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96; ORAG: 1.41, 95% CI: 1.30-1.54; ORGG: 1.22, 95% CI: 1.13-1.31; p-value3-d.f.: 5.46 × 10-11) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83; ORGA: 1.52, 95% CI: 1.38-1.68; ORAA: 1.13, 95% CI: 1.06-1.21; p-value2-d.f.: 7.84 × 10-09). DISCUSSION: These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
dc.description.confidentialfalse
dc.format.pagination511-520
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37365285
dc.identifier.citationDimou N, Kim AE, Flanagan O, Murphy N, Diez-Obrero V, Shcherbina A, Aglago EK, Bouras E, Campbell PT, Casey G, Gallinger S, Gruber SB, Jenkins MA, Lin Y, Moreno V, Ruiz-Narvaez E, Stern MC, Tian Y, Tsilidis KK, Arndt V, Barry EL, Baurley JW, Berndt SI, Bézieau S, Bien SA, Bishop DT, Brenner H, Budiarto A, Carreras-Torres R, Cenggoro TW, Chan AT, Chang-Claude J, Chanock SJ, Chen X, Conti DV, Dampier CH, Devall M, Drew DA, Figueiredo JC, Giles GG, Gsur A, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Jordahl K, Kawaguchi E, Keku TO, Larsson SC, Le Marchand L, Lewinger JP, Li L, Mahesworo B, Morrison J, Newcomb PA, Newton CC, Obon-Santacana M, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Peoples AR, Pharoah PDP, Platz EA, Potter JD, Rennert G, Scacheri PC, Schoen RE, Su Y-R, Tangen CM, Thibodeau SN, Thomas DC, Ulrich CM, Um CY, van Duijnhoven FJB, Visvanathan K, Vodicka P, Vodickova L, White E, Wolk A, Woods MO, Qu C, Kundaje A, Hsu L, Gauderman WJ, Gunter MJ, Peters U. (2023). Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.. Br J Cancer. 129. 3. (pp. 511-520).
dc.identifier.doi10.1038/s41416-023-02312-z
dc.identifier.eissn1532-1827
dc.identifier.elements-typejournal-article
dc.identifier.issn0007-0920
dc.identifier.pii10.1038/s41416-023-02312-z
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/71340
dc.languageeng
dc.publisherSpringer Nature
dc.publisher.urihttps://www.nature.com/articles/s41416-023-02312-z
dc.relation.isPartOfBr J Cancer
dc.rights(c) 2023 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectGene-Environment Interaction
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectDiabetes Mellitus
dc.subjectColorectal Neoplasms
dc.subjectPolymorphism, Single Nucleotide
dc.subjectGenome-Wide Association Study
dc.subjectMicrofilament Proteins
dc.titleProbing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
dc.typeJournal article
pubs.elements-id462392
pubs.organisational-groupCollege of Health
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