Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes

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dc.citation.volume7
dc.contributor.authorKamm JL
dc.contributor.authorRiley CB
dc.contributor.authorParlane N
dc.contributor.authorGee EK
dc.contributor.authorMcIlwraith CW
dc.contributor.editorSchnabel LV
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-02-01T02:19:16Z
dc.date.accessioned2024-07-25T06:38:55Z
dc.date.available2021-01-13
dc.date.available2024-02-01T02:19:16Z
dc.date.available2024-07-25T06:38:55Z
dc.date.issued2021-01-13
dc.description.abstractDespite significant immunosuppressive activity, allogeneic mesenchymal stromal cells (MSCs) carry an inherent risk of immune rejection when transferred into a recipient. In naïve recipients, this immune response is initially driven by the innate immune system, an immediate reaction to the foreign cells, and later, the adaptive immune system, a delayed response that causes cell death due to recognition of specific alloantigens by host cells and antibodies. This review describes the actions of MSCs to both suppress and activate the different arms of the immune system. We then review the survival and effectiveness of the currently used allogeneic MSC treatments.
dc.description.confidentialfalse
dc.edition.edition2020
dc.format.pagination617647-
dc.identifier.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33521090
dc.identifier.citationKamm JL, Riley CB, Parlane N, Gee EK, McIlwraith CW. (2020). Interactions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes.. Front Vet Sci. 7. (pp. 617647-).
dc.identifier.doi10.3389/fvets.2020.617647
dc.identifier.eissn2297-1769
dc.identifier.elements-typejournal-article
dc.identifier.issn2297-1769
dc.identifier.numberARTN 617647
dc.identifier.urihttps://mro.massey.ac.nz/handle/10179/70609
dc.languageeng
dc.publisherFrontiers Media S.A.
dc.publisher.urihttps://www.frontiersin.org/articles/10.3389/fvets.2020.617647/full
dc.relation.isPartOfFront Vet Sci
dc.rights(c) 2021 The Author/s
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectallogeneic
dc.subjectequine
dc.subjectimmune
dc.subjectlymphocyte
dc.subjectmesenchymal stromal cell
dc.titleInteractions Between Allogeneic Mesenchymal Stromal Cells and the Recipient Immune System: A Comparative Review With Relevance to Equine Outcomes
dc.typeJournal article
pubs.elements-id440120
pubs.organisational-groupOther
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